Egg white-derived peptides prevent male reproductive dysfunction induced by mercury in rats

Rizzetti, Danize Aparecida; Martinez, Caroline Silveira; Escobar, Alyne Goulart; Silva, Taiz Martins da; Uranga, José Antonio; Peçanhã, Franck Maciel; Vassallo, Dalton Valentim; Castro, Marta Miguel; Wiggers, Giulia Alessandra

doi:10.1016/j.fct.2016.12.038

Cited by 23 publications

(16 citation statements)

References 68 publications

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“…This research indicates that HgCl 2 decreases sperm activity and viability by causing oxidative stress, and that rutin decreases HgCl 2 toxicity and has a healing effect on sperm parameters. Rizzetti et al (2017) reported no tissue damage when histologically examining testes of rats with 60-day mercury application, but an increase in macrophage counts. A study by Kalender et al (2013) suggested that HgCl 2 causes degeneration, oedema and necrosis, and this may be due to oxidative stress in testicular cell membrane and testicular tissues.…”

Section: Discussionmentioning

confidence: 92%

“…Rizzetti et al () reported no tissue damage when histologically examining testes of rats with 60‐day mercury application, but an increase in macrophage counts. A study by Kalender et al () suggested that HgCl 2 causes degeneration, oedema and necrosis, and this may be due to oxidative stress in testicular cell membrane and testicular tissues.…”

Section: Discussionmentioning

confidence: 99%

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Protective effect of rutin on mercuric chloride‐induced reproductive damage in male rats

et al. 2020

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This study investigated the effects of rutin against reproductive damage caused by toxic mercury in male rats. Thirty‐five Sprague Dawley rats were used. Control group was injected with saline for 7 days. The rutin‐100 group received 100 mg/kg/b.w. rutin for 7 days. Mercuric chloride (HgCl2) group received 1.23 mg/kg/b.w. of HgCl2 for 7 days. Mercury chloride + rutin‐50 group received 50 mg/kg/b.w. rutin and HgCl2 1.23 mg/kg/b.w. for 7 days. HgCl2 + rutin‐100 group received 100 mg/kg/b.w. rutin and HgCl2 1.23 mg/kg/b.w. for 7 days. It was detected that HgCl2 treatment increased malondialdehyde (MDA) levels, tumour necrosis factor‐α (TNF‐α) and cyclooxygenase‐2 (COX‐2) expressions, necrosis and degeneration of spermatogonium, dead and abnormal sperm percentages; tubular walls thinning; and decreased antioxidant enzyme activities and sperm motility. It was determined that rutin application reduced testicular damage caused by HgCl2. In conclusion, rutin administration may treat HgCl2 toxicity in testes.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Protective effect of rutin on mercuric chloride‐induced reproductive damage in male rats

et al. 2020

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“…administration of 0.6% pentobarbital sodium (10 mL/kg). To assess sperm motility, sperm in the cauda epididymides were collected and prepared as described elsewhere [ 25 ]. In brief, each caudal epididymis was placed in 4 mL of saline prewarmed to 34°C and then incised in several places to allow the semen to ooze out.…”

Section: Methodsmentioning

confidence: 99%

Downregulation of DJ-1 Fails to Protect Mitochondrial Complex I Subunit NDUFS3 in the Testes and Contributes to the Asthenozoospermia

Wang

Sun

Zhao

et al. 2018

Mediators of Inflammation

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Asthenozoospermia (AS), an important cause of male infertility, is characterized by reduced sperm motility. Among the aetiologies of AS, inflammation seems to be the main cause. DJ-1, a conserved protein product of the PARK7 gene, is associated with male infertility and plays a role in oxidative stress and inflammation. Although our previous studies showed that a reduction in DJ-1 was accompanied by mitochondrial dysfunction in the sperm of patients with AS, the specific mechanism underlying this association remained unclear. In this study, we found that compared to the patients without AS, the expression of mitochondrial protein nicotinamide adenine dinucleotide dehydrogenase (ubiquinone) Fe-S protein 3 (NDUFS3) was also significantly decreased in the sperm of patients with AS. Similarly, decreased expression of DJ-1 and NDUFS3 and reduced mitochondria complex I activity were evident in a rat model of AS. Moreover, we showed that the interaction between DJ-1 and NDUFS3 in rat testes was weakened by ORN treatment. These results suggest that the impaired mitochondrial activity could be due to the broken interaction between DJ-1 and NDUFS3 and that downregulation of DJ-1 in sperm and testes contributes to AS pathogenesis.

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“…Different heavy metals which have been known to facilitate testicular damage include cadmium 58,59 and mercury. 60 These metals can alter certain oxidative stress parameters, the weight of the testes and its morphology, thus lowering the chances of fertility in men.…”

Section: Testicular Damagementioning

confidence: 99%

“…The sperm number and its morphology were successfully restored by egg white hydrolysate. 60 Although the mechanism of this bioactivity is not yet ascertained, the impressive property of the egg white peptides is also suspected to have occurred via an antioxidant pathway.…”

Section: Herbal Ameliorators Of Testicular Damagementioning

confidence: 99%

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2020

TJNPR

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contaminants in the environmental systems are the heavy metals which gain access into our environment through natural and human activities such as soil erosion and runoffs , mining and rock weathering, indiscriminate disposal of industrial effluents, sewage discharge, unguided use of pesticides, etc. 1 Although some of these metals are "essential", however, above their permissible limits, such metals become harmful to the body. The WHO permissible limit for cadmium, chromium, copper, lead, manganese and nickel in drinking water are 0.003, 0.05, 2.00, 0.01, 0.50, and 0.02 mg/L, respectively. 2 Above these levels, these metals are no longer beneficial. When aquatic animals ingest heavy metal-contaminated water, they naturally bio-accumulate the metals. Similarly, when plants are irrigated with such water, heavy metal accumulation occurs. The eventual consumption of these is dangerous as it consequently leads to the development of various life-threatening diseases such as cancer and organ damage among others. The threat of heavy metal poisoning is higher for people in rural areas. Particularly, people in neglected parts of developing nations are more prone to such poisoning because of ignorance and lack of potable water supply. 3

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Egg white-derived peptides prevent male reproductive dysfunction induced by mercury in rats

Cited by 23 publications

References 68 publications

Protective effect of rutin on mercuric chloride‐induced reproductive damage in male rats

Protective effect of rutin on mercuric chloride‐induced reproductive damage in male rats

Downregulation of DJ-1 Fails to Protect Mitochondrial Complex I Subunit NDUFS3 in the Testes and Contributes to the Asthenozoospermia

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