Antifungal effects of phytocompounds on Candida species alone and in combination with fluconazole

Lü, Mengjiao; Li, Tao; Wan, Jianjian; Liu, Xiuyun; Yuan, Lei; Sun, Shujuan

doi:10.1016/j.ijantimicag.2016.10.021

Cited by 65 publications

(43 citation statements)

References 135 publications

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“…Phenylpropanoids are other naturally occurring compounds categorized as coumarins, phenylpropanoic acid, and lignans frequently studied for their anti-Candida properties [117]. Navarro-Garcia et al [118] and Raut et al [119] found that a coumarin (scopoletin) and two phenylpropanoic acids (salicylaldehyde and anisyl alcohol) have antifungal property against C. albicans, with MICs of 25, 31, and 31 μg/mL, respectively.…”

Section: Phytochemicals: Polyphenols As Substances Most Found In Plantsmentioning

confidence: 99%

Phytochemicals and Their Antifungal Potential against Pathogenic Yeasts

Monteiro¹,

Santos²

2020

Phytochemicals in Human Health

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The rate of fungal infections is increasing rapidly, and pathogenesis of their species is poorly understood. Among fungi, Candida species are a major cause of morbidity and mortality worldwide and thus represent a serious threat to public health. In addition, Cryptococcus spp. are yeasts responsible for serious lung infections and meningitis. Polyenes, fluoropyrimidines, echinocandins, and azoles are used as commercial antifungal agents to treat fungal infections. However, the presence of intrinsic and developed resistance against azole antifungals has been extensively documented. The re-emergence of classical fungal diseases has occurred because of the increment of the antifungal resistance phenomenon. In this way, the development of new satisfactory therapy for fungal diseases persists as a major challenge of present-day medicine. The urgent need includes the development of alternative drugs that are more efficient and tolerant than those traditional already in use. The identification of new substances with potential antifungal effect at low concentrations or in combination is also a possibility. This chapter briefly examines the infections caused by Candida and Cryptococcus species and focuses on describing some of the promising alternative molecules and/or substances that could be used as antifungal agents, their mechanisms of action, and their use in combination with traditional drugs.

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Section: Phytochemicals: Polyphenols As Substances Most Found In Plantsmentioning

confidence: 99%

Phytochemicals and Their Antifungal Potential against Pathogenic Yeasts

Monteiro¹,

Santos²

2020

Phytochemicals in Human Health

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“…31.25 mg mL À1 for C. albicans. At predetermined time periods (0, 2,4,6,8,10,12,14,16,18,20,22, and 24 h) aer incubation with agitation at 37 C, 1 mL aliquot to each sample was removed from the conical ask and growth was measured turbidometrically at 600 nm using Thermo Multiskan spectrophotometer. Optical density (O.D.)…”

Section: Biologymentioning

confidence: 99%

“…The most common species causing infections are C. albicans, C. glabrata, C. tropicalis, C. parapsilosis and C. krusei. 3,4 Currently used antifungal drugs for the treatment of candidiasis include polyenes, azoles, echinocandins, allylamines, and ucytosine. 5 Among these, azole antifungals including uconazole, itraconazole, voriconazole, posaconazole, miconazole etc.…”

Section: Introductionmentioning

confidence: 99%

1,2,3-Triazole–quinazolin-4(3H)-one conjugates: evolution of ergosterol inhibitor as anticandidal agent

et al. 2018

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“…For instance, the simplest natural CA, trans-cinnamic acid ((2E)-3-phenylprop-2-enoic acid), can be found in the bark of several tree species from the genus Cinnamomum [1], or in the resinous exudates of trees from the genus Liquidamber [2], whereas hydroxycinnamic acids (phenolic acids) like p-coumaric, caffeic, ferulic, and sinapic acids, as well as derived compounds, are present in many different parts of a wide panoply of plants, including fruits, leaves, flowers, and others [1][2][3][4]. These acids are frequently found in a conjugated form, constituting key building blocks of complex polyphenols, such as acylated derivatives of flavonoid glycosides [5], and they have a number of biological roles in plants, from protection against microbes long been explored for their potential therapeutic applications, most of which related to their antioxidant, antimicrobial, and antineoplastic properties [4,[7][8][9][10][11][12][13][14]. The potential of CA-based compounds as therapeutic agents for other conditions, including Alzheimer's Disease [15], other nervous system disorders [16,17], acute pain [18], inflammation [19], diabetes [20,21], viral infections [22], tuberculosis [23][24][25][26], and malaria [26][27][28][29], among others, has also been addressed.…”

Section: Introductionmentioning

confidence: 99%

Cinnamic Acid Conjugates in the Rescuing and Repurposing of Classical Antimalarial Drugs

et al. 2019

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Cinnamic acids are compounds of natural origin that can be found in many different parts of a wide panoply of plants, where they play the most diverse biological roles, often in a conjugated form. For a long time, this has been driving Medicinal Chemists towards the investigation of the therapeutic potential of natural, semi-synthetic, or fully synthetic cinnamic acid conjugates. These efforts have been steadily disclosing promising drug leads, but a wide chemical space remains that deserves to be further explored. Amongst different reported approaches, the combination or conjugation of cinnamic acids with known drugs has been addressed in an attempt to produce either synergistic or multi-target action. In this connection, the present review will focus on efforts of the past decade regarding conjugation with cinnamic acids as a tool for the rescuing or the repurposing of classical antimalarial drugs, and also on future perspectives in this particular field of research.

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Antifungal effects of phytocompounds on Candida species alone and in combination with fluconazole

Cited by 65 publications

References 135 publications

Phytochemicals and Their Antifungal Potential against Pathogenic Yeasts

Phytochemicals and Their Antifungal Potential against Pathogenic Yeasts

1,2,3-Triazole–quinazolin-4(3H)-one conjugates: evolution of ergosterol inhibitor as anticandidal agent

Cinnamic Acid Conjugates in the Rescuing and Repurposing of Classical Antimalarial Drugs

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