Women With Polycystic Ovary Syndrome Have Comparable Hip Bone Geometry to Age-Matched Control Women

McBreairty, Laura E.; Zello, Gordon A.; Gordon, Julianne J.; Serrao, Shani; Pierson, R.A.; Chizen, Donna R.; Chilibeck, Philip D.

doi:10.1016/j.jocd.2016.10.007

Cited by 10 publications

(2 citation statements)

References 30 publications

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“…to underlie the endocrine and paracrine derangements that affect muscle health in PCOS. 124,125 Besides adiposity, we and others have proposed alterations in the proliferation and differentiation of myogenic cell lines, 126,127 growth hormone axis, gonadotropin-releasing hormone, and estrogens, coupled with pro-inflammation and oxidative stress to affect muscle health (through mechanisms described in greater details previously 27,33,37,124,125,[128][129][130][131][132][133][134][135] ). Nevertheless, we acknowledge many questions remain about how and why these changes may affect PCOS health complications, including metabolic and reproductive status.…”

Section: Discussionmentioning

confidence: 99%

Obesity, but not hyperandrogenism or insulin resistance, predicts skeletal muscle mass in reproductive‐aged women with polycystic ovary syndrome: A systematic review and meta‐analysis of 45 observational studies

et al. 2021

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Women with polycystic ovary syndrome (PCOS) exhibit reduced muscle insulinmediated glucose uptake, potentially attributed to altered muscle mass; however, this is inconclusive. Altered muscle mass may aggravate PCOS complications. Our systematic review and meta-analysis evaluated whether PCOS alters muscle mass and function. Databases (MEDLINE, Web of Science, Scopus) were searched through September 2, 2020, for studies documenting skeletal muscle mass (lean tissue mass) and function (strength) in PCOS and control groups. The primary outcome was total lean body mass (LBM) or fat-free mass (FFM). Data were pooled by random-effects models and expressed as mean differences and 95% confidence intervals. Forty-five studies (n = 3676 participants) were eligible. Women with PCOS had increased total (0.83 [0.08,1.58] kg; p = 0.03; I 2 = 72.0%) yet comparable trunk (0.84 [−0.37,2.05] kg; p = 0.15; I 2 = 73.0%) LBM or FFM versus controls. Results of metaregression analyses showed no associations between mean differences between groups in total testosterone or homeostatic model assessment of insulin resistance and total or trunk LBM or FFM (All: p ≥ 0.75). Mean differences in body mass index (BMI) were associated with total (0.65 [0.23,1.06] kg; p < 0.01; I 2 = 56.9%) and trunk (0.56 [0.11,1.01] kg; p = 0.02; I 2 = 42.8%) LBM or FFM. The PCOS subgroup with BMI ≥ 25 kg/m 2 had greater total LBM or FFM versus controls (1.58 [0.82,2.34] kg; p < 0.01; I 2 = 64.0%) unlike the PCOS subgroup with BMI < 25 kg/m 2 (−0.45 [−1.94,1.05] kg; p = 0.53; I 2 = 69.5%). Appendicular lean mass and muscle strength data were contradictory and described narratively, as meta-analyses were impossible.

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Section: Discussionmentioning

confidence: 99%

Obesity, but not hyperandrogenism or insulin resistance, predicts skeletal muscle mass in reproductive‐aged women with polycystic ovary syndrome: A systematic review and meta‐analysis of 45 observational studies

et al. 2021

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“…BMD is a major determinant of bone strength, but fragility fractures can occur also in women with normal or slightly reduced BMD as observed in the general population [ 109 ]. In PCOS women, some studies reported lower BMD values [ 111 , 112 , 113 , 114 , 115 ], while others reported no difference in BMD in comparison with healthy controls [ 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 ], probably due to differences in selection criteria and age of participants. A systematic review and meta-analysis showed that, in comparison with controls, women with PCOS and BMI < 27 kg/m², but not women with PCOS with BMI ≥ 27 kg/m², have decreased spinal and femur BMD, suggesting a role for adiposity in contributing to bone parameters [ 66 ].…”

Section: Vitamin D and Pcosmentioning

confidence: 99%

Vitamin D, Bone Metabolism, and Fracture Risk in Polycystic Ovary Syndrome

et al. 2021

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Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among premenopausal women. PCOS may have reproductive, metabolic, cardiovascular, and psychological implications. Vitamin D deficit is often encountered in PCOS women and may contribute to the pathophysiology of this disorder. As of the key role of vitamin D in bone and mineral metabolism, and because the vitamin D status appears to be closely linked with the PCOS manifestations including insulin resistance, obesity, ovulatory and menstrual irregularities, oxidative stress and PTH elevation, hypovitaminosis D may directly and indirectly via the different facets of PCOS impair bone health in these women. Although limited data are available on life-long fracture risk in women with PCOS, the importance of preserving bone health in youth and adults to prevent osteoporosis and related fractures is also recognized in PCOS women. Evidence of the association between vitamin D and the clinical hallmarks of PCOS are summarized and discussed. Vitamin D arises as a cornerstone in women with PCOS and contributes to the pathophysiological link between PCOS and bone metabolism.

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The Relationship Between Polycystic Ovarian Syndrome, Periodontal Disease, and Osteoporosis

Young

Ward

2020

Reprod. Sci.

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Women With Polycystic Ovary Syndrome Have Comparable Hip Bone Geometry to Age-Matched Control Women

Cited by 10 publications

References 30 publications

Obesity, but not hyperandrogenism or insulin resistance, predicts skeletal muscle mass in reproductive‐aged women with polycystic ovary syndrome: A systematic review and meta‐analysis of 45 observational studies

Obesity, but not hyperandrogenism or insulin resistance, predicts skeletal muscle mass in reproductive‐aged women with polycystic ovary syndrome: A systematic review and meta‐analysis of 45 observational studies

Vitamin D, Bone Metabolism, and Fracture Risk in Polycystic Ovary Syndrome

The Relationship Between Polycystic Ovarian Syndrome, Periodontal Disease, and Osteoporosis

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