The Combination of Resveratrol and High-Fluence Light Emitting Diode-Red Light Produces Synergistic Photobotanical Inhibition of Fibroblast Proliferation and Collagen Synthesis: A Novel Treatment for Skin Fibrosis

Mamalis, Andrew; Jagdeo, Jared

doi:10.1097/dss.0000000000000921

Cited by 12 publications

(4 citation statements)

References 19 publications

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“…The literature is contradictory regarding the biological effects of the red LED irradiation because of different parameters that were employed, such as the energy density and of cell type (Vinck et al, 2003;Huang et al, 2007;Zhang et al, 2009;Volpato et al, 2011;Fushimi et al, 2012;Peng et al, 2012;Teuschl et al, 2015;Oliveira et al, 2016;Mamalis et al, 2016;Kim et al, 2017;Mamalis and Jagdeo, 2017;Han et al, 2018). In the present study, considering that no differences were observed in the cell viability using 0.2, 1.45 and 2.91 J/cm 2 , an intermediate energy density of 1.45 J/cm 2 was used.…”

Section: Discussionmentioning

confidence: 80%

“…that the red LED irradiation (625-635 nm) stimulated collagen synthesis in fibroblast culture. Studies by Mamalis et al, (2016) and Mamalis and Jagdeo (2017) showed that red LED irradiation (633nm) inhibited collagen production in vitro. When associated the ASC co-culture and the red LED irradiation, surprisingly TGF-β1 was not detected, indicating another molecule for stimulation of collagen synthesis in the FC group, since the amount of collagen types I and III remained similar to other groups.…”

Section: Discussionmentioning

confidence: 96%

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Inhibitory effect of red LED irradiation on fibroblasts and co-culture of adipose-derived mesenchymal stem cells

Theodoro

Fujii

Lucke

et al. 2020

Heliyon

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The objective of this study was to evaluate the effects of red Light Emiting Diode (red LED) irradiation on fibroblasts in adipose-derived mesenchymal stem cells (ASC) co-culture on the scratch assay. We hypothesized that red LED irradiation could stimulate paracrine secretion of ASC, contributing to the activation of genes and molecules involved in cell migration and tissue repair. ASC were co-cultured with NIH/3T3 fibroblasts through direct contact and subjected to red LED irradiation (1.45 J/cm 2 /5min6s) after the scratch assay, during 4 days. Four groups were established: fibroblasts (F), fibroblasts þ LED (FL), fibroblasts þ ASC (FC) and fibroblasts þ LED þ ASC (FLC). The analyzes were based on Ctgf and Reck expression, quantification of collagen types I and III, tenomodulin, VEGF, TGF-β1, MMP-2 and MMP-9, as well as viability analysis and cell migration. Higher Ctgf expression was observed in FC compared to F. Group FC presented higher amount of tenomodulin and VEGF in relation to the other groups. In the cell migration analysis, a higher number of cells was observed in the scratched area of the FC group on the 4 th day. There were no differences between groups considering cell viability, Reck expression, amount of collagen types I and III, MMP-2 and TGF-β1, whereas TGF-β1 was not detected in the FC group and the MMP-9 in none of the groups. Our hypothesis was not supported by the results because the red LED irradiation decreased the healing response of ASC. An inhibitory effect of the LED irradiation associated with ASC co-culture was observed with reduction of the amount of TGF-β1, VEGF and tenomodulin, possibly involved in the reduced cell migration. In turn, the ASC alone seem to have modulated fibroblast behavior by increasing Ctgf, VEGF and tenomodulin, leading to greater cell migration. In conclusion, red LED and ASC therapy can have independent effects on fibroblast wound healing, but the combination of both does not have a synergistic effect. Therefore, future studies with other parameters of red LED associated with ASC should be tested aiming clinical application for tissue repair.

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Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 96%

Inhibitory effect of red LED irradiation on fibroblasts and co-culture of adipose-derived mesenchymal stem cells

Theodoro

Fujii

Lucke

et al. 2020

Heliyon

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“…RSV exhibits environmental instability, particularly its sensitivity to ultraviolet radiation, oxygen, alkaline pH, and elevated temperatures, leading to diminished bioavailability and biological activity. Consequently, numerous RSV derivatives, especially methylated compounds, are under investigation for enhanced stability and efficacy ( Liu et al, 2011 ; Mamalis and Jagdeo, 2017 ). Compared to other stilbene compounds, pterostilbene boasts higher bioavailability, potentially amplifying its nutritional advantages and leading to noteworthy clinical outcomes ( Kapetanovic et al, 2011 ).…”

Section: Introductionmentioning

confidence: 99%

Pterostilbene in the treatment of inflammatory and oncological diseases

Liu,

Tang,

Xiang

et al. 2024

Front. Pharmacol.

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Pterostilbene (PTS), a naturally occurring analog of resveratrol (RSV), has garnered significant attention due to its potential therapeutic effects in treating inflammatory and oncological diseases. This comprehensive review elucidates the pharmacological properties, mechanisms of action, and therapeutic potential of PTS. Various studies indicate that PTS exhibits anti-inflammatory, antioxidant, and antitumour properties, potentially making it a promising candidate for clinical applications. Its influence on regulatory pathways like NF-κB and PI3K/Akt underscores its diverse strategies in addressing diseases. Additionally, PTS showcases a favorable pharmacokinetic profile with better oral bioavailability compared to other stilbenoids, thus enhancing its therapeutic potential. Given these findings, there is an increased interest in incorporating PTS into treatment regimens for inflammatory and cancer-related conditions. However, more extensive clinical trials are imperative to establish its safety and efficacy in diverse patient populations.

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“…In 1961, Robert Biard and Gary Pittman found infrared radiation from GaAs, , and the next year, Holonyak invented the first visible light-emitting diode (LED). , Recently, Nakamura et al invented high-brightness blue LEDs, which won the Nobel prize in physics. − The development of LEDs is becoming more mature day by day. Compared with the traditional light source, LEDs have more advantages, such as small size, ideal luminous efficiency, long lifetime, fast switching time, relatively low turn-on voltage, and little mercury environmental pollution. , The LEDs are not only used in lighting but also used in optical communications and even in industrial processes and medical treatment. − …”

Section: Introductionmentioning

confidence: 99%

Graphene–Insulator–Semiconductor Ultraviolet Light-Responsive Nitride LEDs for Multi-Applications

Wang

et al. 2020

ACS Appl. Electron. Mater.

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Light emitting diodes (LEDs) are ubiquitous in our daily life nowadays. Among them, ultraviolet LEDs are unique because of their wide range of potential applications, spanning from biomedicine, environmental protection to public health. However, fabricating highly efficient and cost-effective ultraviolet LEDs still remains as a great challenge. In this work, a graphene–insulator–semiconductor (GIS) ultraviolet LED based on the mechanism of quantum tunneling has been designed, fabricated, and demonstrated, which possesses state-of-the-art multi-purposes, including electroluminescence, outstanding detection performance, and economical fabrication processes. The GIS ultraviolet device consists of an AlGaN thin film, a SiO2 insulating layer, and a graphene transparent electrode. Under a forward bias, the electroluminescence can be induced by the recombination of hole tunneling from graphene into the valence band edge of n-AlGaN and electrons in the conduction band with a high emission efficiency exceeding 10%. In addition, our GIS ultraviolet LEDs show an excellent ultraviolet-detecting capability and dual-side light emission, which can be used in optical communications and for the development of multifunctional optoelectronic devices. Notably, unlike the conventional LEDs, which requires both p-type and n-type doping of a semiconductor, the developed approach shown here only needs one type of doping. This approach can be applied to many other semiconductors with the inherent difficulty of both type of doping.

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The Combination of Resveratrol and High-Fluence Light Emitting Diode-Red Light Produces Synergistic Photobotanical Inhibition of Fibroblast Proliferation and Collagen Synthesis: A Novel Treatment for Skin Fibrosis

Abstract: The study, discovery, and use of photobotanical combinations may usher in new therapeutics or phototherapy adjuvants for the treatment of dermatologic diseases.

Cited by 12 publications

References 19 publications

Inhibitory effect of red LED irradiation on fibroblasts and co-culture of adipose-derived mesenchymal stem cells

Inhibitory effect of red LED irradiation on fibroblasts and co-culture of adipose-derived mesenchymal stem cells

Pterostilbene in the treatment of inflammatory and oncological diseases

Graphene–Insulator–Semiconductor Ultraviolet Light-Responsive Nitride LEDs for Multi-Applications

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