Grilling enhances antidiarrheal activity of Terminalia bellerica Roxb. fruits

Pandey, Garima; Gupta, Sanchita; Bhatia, Ashok Kumar; Sidhu, O. P.; Rawat, Ajay Kumar Singh; Rao, Ch. V.

doi:10.1016/j.jep.2016.12.003

Cited by 15 publications

(6 citation statements)

References 11 publications

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“…Chen et al, [53] have reported that gallic acid can prevent binding of E. coli toxin to ganglioside receptor. Presence of gallic acid has also been associated with antidiarrhoeal action due to its anti-secretory properties [54]. Quercetin is known to have antispasmolytic activity [17].…”

Section: Discussionmentioning

confidence: 99%

1H nuclear magnetic resonance-based metabolite profiling of guava leaf extract: an attempt to develop a prototype for standardization of plant extracts

Gholkar

Daswani

et al. 2021

BMC Complement Med Ther

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Background Herbal medicines are fast gaining popularity. However, their acceptability by modern practitioners is low which is often due to lack of standardization. Several approaches towards standardization of herbals have been employed. The current study attempted to recognize key peaks from 1H NMR spectra which together would comprise of a spectral fingerprint relating to efficacy of Psidium guajava (guava) leaf extract as an antidiarrhoeal when a number of unidentified active principles are involved. Methods Ninety samples of guava leaves were collected from three locations over three seasons. Hydroalcoholic (water and ethanol, 50:50) extracts of these samples were prepared and their 1H NMR spectra were acquired. Spectra were also obtained for quercetin, ferulic acid and gallic acid as standards. Eight bioassays reflecting different stages of diarrhoeal pathogenesis were undertaken and based on pre-decided cut-offs, the extracts were classified as ‘good’ or ‘poor’ extracts. The bioactivity data was then correlated with the 1H NMR profiles using Regression or Orthogonal Partial Least Square-Discriminant Analysis (OPLS-DA). Results OPLS-DA showed seasonal and regional segregation of extracts. Significant models were established for seven bioassays, namely those for anti-bacterial activity against Shigella flexneri and Vibrio cholerae, adherence of E. coli, invasion of E. coli and S. flexneri and production and binding of toxin produced by V. cholerae. It was observed that none of the extracts were good or bad across all the bioassays. The spectral analysis showed multiple peaks correlating with a particular activity. Based on NMR and LC-MS/MS, it was noted that the extracts contained quercetin, ferulic acid and gallic acid. However, they did not correlate with the peaks that segregated extracts with good and poor activity. Conclusions The current study identified key peaks in 1H NMR spectra contributing to the anti-diarrhoeal activity of guava leaf extracts. The approach of using spectral fingerprinting employed in the present study can thus be used as a prototype towards standardization of plant extracts with respect to efficacy.

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Section: Discussionmentioning

confidence: 99%

1H nuclear magnetic resonance-based metabolite profiling of guava leaf extract: an attempt to develop a prototype for standardization of plant extracts

Gholkar

Daswani

et al. 2021

BMC Complement Med Ther

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“…Terminalia species were also reported to be used in the treatment of diarrhea [95], Alzheimer’s disease [112], psoriasis [164], liver disease [170], kidney disease [171], etc. Terminalosides A–K ( 249–259 ) from the leaves of the Bangladeshi medicinal plant T. citrina possess estrogen-inhibitory properties.…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

The Genus Terminalia (Combretaceae): An Ethnopharmacological, Phytochemical and Pharmacological Review

Zhang

Kaunda

Zhu

et al. 2019

Nat. Prod. Bioprospect.

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Terminalia Linn, a genus of mostly medium or large trees in the family Combretaceae with about 250 species in the world, is distributed mainly in southern Asia, Himalayas, Madagascar, Australia, and the tropical and subtropical regions of Africa. Many species are used widely in many traditional medicinal systems, e.g., traditional Chinese medicine, Tibetan medicine, and Indian Ayurvedic medicine practices. So far, about 39 species have been phytochemically studied, which led to the identification of 368 compounds, including terpenoids, tannins, flavonoids, phenylpropanoids, simple phenolics and so on. Some of the isolates showed various bioactivities, in vitro or in vivo, such as antitumor, anti HIV-1, antifungal, antimicrobial, antimalarial, antioxidant, diarrhea and analgesic. This review covers research articles from 1934 to 2018, retrieved from SciFinder, Wikipedia, Google Scholar, Chinese Knowledge Network and Baidu Scholar by using “Terminalia” as the search term (“all fields”) with no specific time frame setting for the search. Thirty-nine important medicinal and edible Terminalia species were selected and summarized on their geographical distribution, traditional uses, phytochemistry and related pharmacological activities.

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“…Roxb. is used to treat diarrhea based on its antioxidant and antibacterial properties ( Pandey et al., 2017 ). It has been found that extracts of T. bellirica (Gaertn.)…”

Section: Terminalia Sp Medicinal Potential (Folk Medicinal mentioning

confidence: 99%

“…is traditionally used for cardioprotective and hepatoprotective purposes in India and Sri Lanka ( Kapoor et al., 2014 ); T. bellirica (Gaertn.) Roxb., is widely used on treating diarrhea ( Pandey et al., 2017 ); Terminalia brownii Fresen., has been used to treat brown-erythematous excoriated papules and plaques ( Kibar Ozturk et al., 2018 ); T. chebula Retz. is widely used to treat dementia, constipation, and diabetes in traditional Indian and Iranian medicine ( Jokar et al., 2016 ), etc.…”

Section: Introductionmentioning

confidence: 99%

Plants of the Genus Terminalia: An Insight on Its Biological Potentials, Pre-Clinical and Clinical Studies

et al. 2020

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The evaluation and confirmation of healing properties of several plant species of genus Terminalia based on their traditional uses and the clinical claims are of utmost importance. Genus Terminalia has received more attention to assess and validate the therapeutic potential and clinical approval due to its immense folk medicinal and traditional applications. Various species of Terminalia genus are used in the form of herbal medicine and formulations, in treatment of diseases, including headache, fever, pneumonia, flu, geriatric, cancer, to improve memory, abdominal and back pain, cough and cold, conjunctivitis, diarrhea, heart disorder, leprosy, sexually transmitted diseases, and urinary tract disorders. These are reported to possess numerous biological properties, counting: antibacterial, antifungal, antiinflammatory, antiviral, antiretroviral, antioxidant, and antipa7rasitic. This current research review aims to update the detailed biological activities, pre-clinical and clinical studies of various extracts and secondary metabolites from several plant species under the genus Terminalia , along with information on the traditional uses and chemical composition to develop a promising strategy for their potential applications in the form of medicine or use in modern drug formulations for treating diseases like pneumonia, flu, and other types of viral infections or controlling human contagions.

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Grilling enhances antidiarrheal activity of Terminalia bellerica Roxb. fruits

Cited by 15 publications

References 11 publications

1H nuclear magnetic resonance-based metabolite profiling of guava leaf extract: an attempt to develop a prototype for standardization of plant extracts

1H nuclear magnetic resonance-based metabolite profiling of guava leaf extract: an attempt to develop a prototype for standardization of plant extracts

The Genus Terminalia (Combretaceae): An Ethnopharmacological, Phytochemical and Pharmacological Review

Plants of the Genus Terminalia: An Insight on Its Biological Potentials, Pre-Clinical and Clinical Studies

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