Physicochemical Characteristics of Brazilian Green Propolis Evaluated During a Six-Year Period

Figueiredo, Sônia Maria de; Binda, Nancy Scardua; Filho, Sidney Augusto Vieira; Almeida, Bruno de Moura; Abreu, Sheila R.L.; Paulino, Niraldo; Pastore, Gláucia Maria; Sato, Hélia Harumi; Theodoropoulos, Viviane Cristina Toreti; Tapia, Eulália Vargas; Park, Yong K.; Caligiorne, Rachel Basques

doi:10.2174/1570163813666161220151425

Cited by 7 publications

(3 citation statements)

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“…In general, all of the mixtures displayed a similar antioxidant potential ( Table 2 ), once again in the range reported both for single European (26.45 μg/mL Ireland and 27.72 μg /mL Czech Republic) [ 29 , 34 ] and for other individual Portuguese propolis samples [ 35 ], even being propolis diverse in this activity as well [ 36 , 37 ]. A lower DPPH• scavenging activity (IC 50 = 32.35 ± 2.84 μg mL −1 ) was reported for an EE of Chinese propolis [ 38 ], whereas Brazilian green propolis appears to have the best antioxidant potential [ 39 ].…”

Section: Resultsmentioning

confidence: 99%

Mixing Propolis from Different Apiaries and Harvesting Years: Towards Propolis Standardization?

et al. 2022

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Global demand for safe, effective and natural products has been increasing in parallel with consumers’ concerns about personal and environmental health. Propolis, a traditional and potentially medicinal product with several health benefits, is a beehive product with a worldwide reputation. However, despite the bioactivities reported, the low productivity and high chemical heterogeneity have been extensively hampering broader industrial uses. To assist in overcoming some of these problems, we prepared and characterized mixtures of ethanol extracts of a heterogeneous propolis sample (Pereiro) collected over a five-year period (2011–2015) and, additionally, we mixed two different propolis samples from distinct regions of Portugal (Pereiro and Gerês), also harvested at different times. An investigation of the antimicrobial and antioxidant properties, as well as characterization of the chemical composition of the eleven propolis blends were performed in this work. The antioxidant and antimicrobial activities of such blends of propolis samples, either from different localities and/or different years, were maintained, or even enhanced, when a comparison of the individual extracts was conducted. The differences in the chemical composition of the original propolis samples were also diluted in the mixtures. The results reemphasize the great potential of propolis and suggest that mixing different samples, regardless of provenance or harvesting date, can contribute to propolis standardization while simultaneously increasing its availability and adding value to this beehive byproduct.

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Section: Resultsmentioning

confidence: 99%

Mixing Propolis from Different Apiaries and Harvesting Years: Towards Propolis Standardization?

et al. 2022

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“…1). Green propolis chemical components were identified for scientific studies by HPLC and reverse phase [27][28][29][30]. The gel final composition was composed of Brazilian green propolis (5%), propylene glycol, hydroxypropyl methylcellulose, polysorbate 20, and purified water.…”

Section: Mucoadherent Gel Formulation and Prescriptionmentioning

confidence: 99%

Grade IV oral mucositis treatment with Brazilian green propolis mucoadherent gel

Silva,

Caldeira,

de Sousa

et al. 2023

Explor Drug Sci

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Green propolis is collected by Apis mellifera from the flowers and buds of Baccharis dracunculifolia. It has several chemical compounds that confer anti-inflammatory, antimicrobial, healing, and antioxidant biological activities. To report a series of clinical cases in the treatment of oral mucositis (OM) in patients with cancer undergoing radiotherapy in the head and neck region. Rapid treatment of OM means restoring quality of life to patients and lowering the cost of cancer treatment for public health. There male patients with oral carcinoma undergoing radiotherapy treatment were followed between August 2018 and April 2019. The patients presented themselves to the clinics in the Faculty of Dentistry of Federal University of Minas Gerais with erythematous and ulcerated coalescing lesions with purulent fibrin pseudomembranes in the oral mucosa, classified as grade IV OM according to the World Health Organization. The patients complained about the inability to eat, drink, and speak, which caused the radiotherapy interruption. After completing the clinical forms, anamnesis, and proper oral hygiene of each patient, a mucoadherent gel containing 5% propolis was prescribed for daily use, with a 3 time-a-day application every 8 h. After 7 days of use, there was an 80% lesion reduction, with total remission after 15 days of its application. The rapid response with total remission of lesions seems to be related to the chemical composition of propolis. Clinical and cellphone monitoring of patients, weekly and daily, respectively, were essential for successful treatment. The patients were monitored for one year, being encouraged to make constant use of the gel to control hyposalivation caused by changes in the salivary glands during radiotherapy.

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“…Among the different types of propolis, green propolis is widely recognized in Brazil due to its diversity of biological activities such as antioxidant capacity. Green Propolis produced by Africanized Apis mellifera bees has a well-established botanical source known as Baccharis dracunculifolia, both of them have already been reported as potential substitutes for synthetic antioxidants intended for use as food additives and functional ingredients due to the potential of its bioactive compounds [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Ultrasound-Assisted Extraction of Antioxidants from Baccharis dracunculifolia and Green Propolis

2020

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Baccharis dracunculifolia or rosemary-of-field is the principal botanical source used by Africanized bees Apis mellifera L. to produce green propolis in Southeastern Brazil. The phenolic compounds present in the plant and green propolis have been reported to be responsible for biological activities such as antioxidant capacity. This study aimed to optimize the ultrasound-assisted extraction of antioxidants compounds from rosemary-of-field using a central composite rotatable design (CCRD), and compare results to green propolis extract. An experimental design was performed to obtain responses of total phenolic content and antioxidant capacity. The results allowed observing that the optimum condition for both Baccharis dracunculifolia floral bud and raw green propolis antioxidant extraction was obtained with 99% ethanol solution. In this condition, Total Phenolic Content (TPC), Ferric Reducing Antioxidant Power (FRAP), and 2,2-diphenyl-1-picryl-hydrazyl (DPPH) values were 612.14 mg GAE. g−1 sample, 534.39 µM ferrous sulfate g−1 sample, and 72.37 µmol TEAC. g−1 sample, respectively, for floral buds. These results have confirmed that optimization is a key step for effective and sustainable extraction processes to be feasible on an industrial scale. The proposed process can be easily adopted on a larger scale, as it uses very few inputs and presents straightforward steps, with the advantage of high efficiency in the extraction of phenolic compounds from the studied matrices compared to the results from the literature. The high concentration of antioxidants indicates that the products obtained can be considered as a sustainable bioactive source for food and cosmetic purposes.

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Physicochemical Characteristics of Brazilian Green Propolis Evaluated During a Six-Year Period

Abstract: Green propolis did not show abrupt seasonal changes during the six years of investigation, and may be considered as an adequate functional ingredient.

Cited by 7 publications

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Mixing Propolis from Different Apiaries and Harvesting Years: Towards Propolis Standardization?

Mixing Propolis from Different Apiaries and Harvesting Years: Towards Propolis Standardization?

Grade IV oral mucositis treatment with Brazilian green propolis mucoadherent gel

Ultrasound-Assisted Extraction of Antioxidants from Baccharis dracunculifolia and Green Propolis

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