28. The Time-Development of the Experimental Cerebra Vascular Disease

Abstract

Although reconstructive operations have been widely recognized as the bes treatment for carotid arterial occlusions, circulation is successfully restored in onl, 30% of cases with the complete occlusions. In the present study, therefore, th treatment with thrombolytic agents and/or anticoagulants have been compared wit] that of thrombectomy. From our experimental studies with 5 different methods of producing caroti(arterial thrombosis in dogs, it was found that thrombotic occlusion was produce(by the method with electric current in 92.5% of cases. Moreover, the thrombotii occlusion produced by this method is likely to become complete in course of days. Using above-mentioned carotid arterial thrombosis, thrombectomy, anti coagulants and thrombolytic agents have been tried immediately, the 2nd, th 3rd and the 5th day respectively. The following results have, so far, been obtained. 1) The restoration of blood circulation was obtained by thrombolytic agent without producing any noticeable side effects including cerebral hemorrhage ii almost the same ratio (40-62.5%) as by thrombectomy in cases within two days 2) The restoration of blood circulation was obtained only in 16.7% either by thrombectomy or thrombolytic agents in cases after 3 days. 3) Such a poor result was restored to 80% by thrombectomy followed b, heparin administration for 48 hours in cases of 3 days.