28 Prediction of neonatal death from pulmonary hypoplasia by fetal pulmonary Doppler after maternal hyperoxygenation

Maternal hyperoxygenation: A potential therapy for congenital heart disease in the fetuses? A systematic review of the current literature

“…1,[4][5][6][7] Fetal response to MH has been a tool used by certain obstetricians for decades as a prognostic measure in various fetal nonprimary cardiac diseases such as congenital diaphragmatic hernia, hydrops, renal abnormalities, chronic premature rupture of membranes, and twin-twin transfusion. 1,[4][5][6][7] Fetal response to MH has been a tool used by certain obstetricians for decades as a prognostic measure in various fetal nonprimary cardiac diseases such as congenital diaphragmatic hernia, hydrops, renal abnormalities, chronic premature rupture of membranes, and twin-twin transfusion.…”

“…1,[4][5][6][7] Fetal response to MH has been a tool used by certain obstetricians for decades as a prognostic measure in various fetal nonprimary cardiac diseases such as congenital diaphragmatic hernia, hydrops, renal abnormalities, chronic premature rupture of membranes, and twin-twin transfusion. 1,4,8,9 More recently, investigators have examined the fetal cardiovascular response to MH as a predictor of prognosis in certain congenital heart disease lesions with encouraging results. 1,4,8,9 More recently, investigators have examined the fetal cardiovascular response to MH as a predictor of prognosis in certain congenital heart disease lesions with encouraging results.…”

“…congenital heart disease (CHD) scenarios, MH leads to an increase in fetal pulmonary blood flow resulting in increased venous return to the left heart and this response increases with gestational age. 1,[4][5][6][7] Fetal response to MH has been a tool used by certain obstetricians for decades as a prognostic measure in various fetal nonprimary cardiac diseases such as congenital diaphragmatic hernia, hydrops, renal abnormalities, chronic premature rupture of membranes, and twin-twin transfusion. 4,7 There are skeptics of the prognostic abilities of the fetal response to MH in fetal nonprimary cardiac diseases.…”

“…4,7 There are skeptics of the prognostic abilities of the fetal response to MH in fetal nonprimary cardiac diseases. 1,4,8,9 More recently, investigators have examined the fetal cardiovascular response to MH as a predictor of prognosis in certain congenital heart disease lesions with encouraging results. 7 More exciting perhaps is the work of these investigators and others studying MH as a potential fetal corrective treatment option for certain congenital heart disease lesions.…”