28-day repeated oral administration study of mechanically fibrillated cellulose nanofibers (fib-CNF) according to OECD TG407
Yoshihiro Yamashita,
Akinori Tokunaga,
Koji Aoki
et al.
Abstract:It is still unclear whether oral administration of mechanically fibrillated cellulose nanofibers (hereafter, fib-CNF), which is widely used among nanofibers, causes toxicity or, on the contrary, improves health, despite the reported safety and even beneficial effects of oral intake of chitin-based nanofibers. Therefore, it is crucial to adhere to the guidelines outlined in OECD TG407 for the evaluation of oral toxicity. This study aimed to assess the safety of orally administered fib-CNF through an acute toxic… Show more
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