Idiopathic hypophosphatemic osteomalacia: recurrent pseudofracture of the proximal femur in a 65-year-old man

Chen, Yixuan; Gao, Yuyan

doi:10.1007/s12020-016-1205-1

Cited by 1 publication

(2 citation statements)

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“…Tumor-induced osteomalacia (TIO) is a paraneoplastic syndrome characterized by severe, rapidly progressing demineralization caused by usually small mesenchymal tumors secreting an excess of FGF23, leading to hypophosphatemia due to phosphate wasting [ 27 ]. It usually occurs in the fourth and fifth decades of life.…”

Section: More Frequent Forms Of Osteomalacia In Clinical Practicementioning

confidence: 99%

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Osteomalacia Is Not a Single Disease

Cianferotti

2022

IJMS

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Among bone-material qualities, mineralization is pivotal in conferring stiffness and toughness to the bone. Osteomalacia, a disease ensuing from inadequate mineralization of the skeleton, is caused by different processes leading to decreased available mineral (calcium and/or phosphate) or enzymatic alterations. Vitamin D deficiency, which remains the major cause of altered mineralization leading to inadequate intestinal calcium and phosphate absorption, may be also associated with other conditions primarily responsible for abnormal mineralization. Given the reality of widespread vitamin D inadequacy, a full biochemical assessment of mineral metabolism is always necessary to rule out or confirm other conditions. Both too-high or too-low serum alkaline phosphatase (ALP) levels are important for diagnosis. Osteomalacic syndrome is reversible, at least in part, by specific treatment. Osteomalacia and bone mineralization themselves constitute largely unexplored fields of research. The true prevalence of the different forms of osteomalacia and the recovery after proper therapy have yet to be determined in the real world. Although non-invasive techniques to assess bone mineralization are not available in clinical practice, the systematic assessment of bone quality could help in refining the diagnosis and guiding the treatment. This review summarizes what is known of osteomalacia recent therapeutic developments and highlights the future issues of research in this field.

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Section: More Frequent Forms Of Osteomalacia In Clinical Practicementioning

confidence: 99%

“…( D ): The transverse fracture line (arrow) revealed by computed tomography scanning (as reproduced with permission from ref. [ 27 ]).…”

Section: Figurementioning

confidence: 99%