CD40 signaling and hepatic steatosis: Unanticipated links

Lepreux, Sébastien; Villeneuve, Julien; Dewitte, Antoine; Bérard, Annie M.; Desmoulière, Alexis; Ripoche, Jean

doi:10.1016/j.clinre.2016.11.002

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Cited by 3 publications

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“…Plasma levels might also be elevated in patients with various inflammatory disorders, such as obesity, 21 cancer 22 and hepatic steatosis. 23 We sought in our study to evaluate sCD40 L as a potential biomarker for T1DM disease complications in a group of Egyptian children.…”

Section: Original Articlementioning

confidence: 99%

Evaluation of soluble CD40L in children with type 1 diabetes mellitus and its relation to diabetes associated vasculopathy

Hodeib

Meabed

Abougabal

et al. 2021

Egypt J Pediatr Allergy Immunol

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Section: Original Articlementioning

confidence: 99%

Evaluation of soluble CD40L in children with type 1 diabetes mellitus and its relation to diabetes associated vasculopathy

Hodeib

Meabed

Abougabal

et al. 2021

Egypt J Pediatr Allergy Immunol

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The bidirectional immune crosstalk in metabolic dysfunction-associated steatotic liver disease

Sawada,

Chung,

Softic

et al. 2023

Cell Metabolism

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A Role for CD154, the CD40 Ligand, in Granulomatous Inflammation

Villeneuve

Desmoulière

Dewitte

et al. 2017

Mediators of Inflammation

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Granulomatous inflammation is a distinctive form of chronic inflammation in which predominant cells include macrophages, epithelioid cells, and multinucleated giant cells. Mechanisms regulating granulomatous inflammation remain ill-understood. CD154, the ligand of CD40, is a key mediator of inflammation. CD154 confers a proinflammatory phenotype to macrophages and controls several macrophagic functions. Here, we studied the contribution of CD154 in a mouse model of toxic liver injury with carbon tetrachloride and a model of absorbable suture graft. In both models, granulomas are triggered in response to endogenous persistent liver calcified necrotic lesions or by grafted sutures. CD154-deficient mice showed delayed clearance of carbon tetrachloride-induced liver calcified necrotic lesions and impaired progression of suture-induced granuloma. In vitro, CD154 stimulated phagocytosis of opsonized erythrocytes by macrophages, suggesting a potential mechanism for the altered granulomatous inflammation in CD154KO mice. These results suggest that CD154 may contribute to the natural history of granulomatous inflammation.

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CD40 signaling and hepatic steatosis: Unanticipated links

Cited by 3 publications

References 194 publications

Evaluation of soluble CD40L in children with type 1 diabetes mellitus and its relation to diabetes associated vasculopathy

Evaluation of soluble CD40L in children with type 1 diabetes mellitus and its relation to diabetes associated vasculopathy

The bidirectional immune crosstalk in metabolic dysfunction-associated steatotic liver disease

A Role for CD154, the CD40 Ligand, in Granulomatous Inflammation

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