Physiopathologie de l’ischémie-reperfusion et du conditionnement ischémique du muscle squelettique – applications cliniques pour le chirurgien vasculaire

Protective effects of Salvianic acid A against multiple-organ ischemia-reperfusion injury: a review

“…A study found that Salvianic acid A sodium did not significantly affect VEGF expression in the initial stages of reperfusion but downregulates VEGF in the late stages of injury, indicating that Salvianic acid A has a certain preventive effect on retinal neovascularization ( Ding et al, 2006 ). I/R injury of skeletal muscle causes a series of physiological and pathological reactions, affecting normal activities of the body ( Delay et al, 2017 ). The specific underlying mechanism may be that after activation, leukocytes migrate and adhere to the surrounding venous endothelial cells, aggravating ischemic injury and preventing microvascular reperfusion by releasing active factors or damaging the microvascular barrier ( Gillani et al, 2012 ).…”