The interplay of plasma treatment and gold coating and ultra-high molecular weight polyethylene: On the cytocompatibility

Novotná, Zuzana; Rimpelová, Silvie; Juřík, Petr; Veselý, Martin; Kolská, Zdeňka; Hubáček, Tomáš; Ruml, Tomáš; Švorčı́k, Václav

doi:10.1016/j.msec.2016.09.057

Cited by 9 publications

(10 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On one hand, the plasma treatment contributed to the increase in surface roughness of the PE substrate, and on the other hand it influenced the surface structure of the modified samples. The increases of surface roughness value after plasma processes are in good agreement with results obtained by Novotná et al [28].…”

Section: Morphological Analysissupporting

confidence: 92%

“…3 at.% in the case of the PE_1, PE_2, and PE_3 series. The growth of oxygen concentration after plasma treatments was strongly affected by the creation of polar oxygen groups, which was also concluded by Novotná et al [28]. In the case of PE_4, the thickness of Si-DLC layer was above 1 µm and the N-DLC layer was out of range of EDS analysis.…”

Section: Morphological Analysissupporting

confidence: 71%

See 1 more Smart Citation

Physicochemical and Biological Activity Analysis of Low-Density Polyethylene Substrate Modified by Multi-Layer Coatings Based on DLC Structures, Obtained Using RF CVD Method

et al. 2018

View full text Add to dashboard Cite

In this paper, the surface properties and selected mechanical and biological properties of various multi-layer systems based on diamond-like carbon structure deposited on low-density polyethylene (LDPE) substrate were studied. Plasma etching and layers deposition (incl. DLC, N-DLC, Si-DLC) were carried out using the RF CVD (radio frequency chemical vapor deposition) method. In particular, polyethylene with deposited N-DLC and DLC layers in one process was characterized by a surface hardness ca. seven times (up to ca. 2.3 GPa) higher than the unmodified substrate. Additionally, its surface roughness was determined to be almost two times higher than the respective plasma-untreated polymer. It is noteworthy that plasma-modified LDPE showed no significant cytotoxicity in vitro. Thus, based on the current research results, it is concluded that a multilayer system (based on DLC coatings) obtained using plasma treatment of the LDPE surface can be proposed as a prospective solution for improving mechanical properties while maintaining biocompatibility.

show abstract

Section: Morphological Analysissupporting

confidence: 92%

Section: Morphological Analysissupporting

confidence: 71%

Physicochemical and Biological Activity Analysis of Low-Density Polyethylene Substrate Modified by Multi-Layer Coatings Based on DLC Structures, Obtained Using RF CVD Method

et al. 2018

View full text Add to dashboard Cite

show abstract

“…5,[13][14][15] Most of the recent works have been focused on the designing of the coating methods, which should protect the bone tissue from periprostheticosteolysis and improve the biocompatibility of the material. Nylon coating, 16 titanium and hydroxyapatite coating, 17 and gold coating 18 showed effectiveness on the improvement of biological performance of UHMWPE. To the best of our knowledge, the studies of applying biomolecular coatings incorporating growth factors to modify UHMWPE have not been accomplished.…”

Section: Introductionmentioning

confidence: 95%

“…39,40 The increased surface roughness even outweighs the enhanced wettability for the adhesion and proliferation of fibroblast cells. 18 Besides, as a versatile biomaterial in tissue engineering, SF is capable of supporting the proliferation and differentiation of BMSCs along the osteogenic lineage. 41 The proliferation level of BMSCs in the UHMWPE-SF/VEGF group was significantly higher than that of the UHMWPE-SF group after 14-day cultivation, because the sustained VEGF release was conductive to BMSC proliferation and adhesion.…”

mentioning

confidence: 99%

Surface modification of vascular endothelial growth factor-loaded silk fibroin to improve biological performance of ultra-high-molecular-weight polyethylene via promoting angiogenesis

Ai¹,

Sheng²,

Cai³

et al. 2017

IJN

View full text Add to dashboard Cite

Ultra-high-molecular-weight polyethylene (UHMWPE) has been applied in orthopedics, as the materials of joint prosthesis, artificial ligaments, and sutures due to its advantages such as high tensile strength, good wear resistance, and chemical stability. However, postoperative osteolysis induced by UHMWPE wear particles and poor bone–implant healing interface due to scarcity of osseointegration is a significant problem and should be solved imperatively. In order to enhance its affinity to bone tissue, vascular endothelial growth factor (VEGF) was loaded on the surface of materials, the loading was performed by silk fibroin (SF) coating to achieve a controlled-release delivery. Several techniques including field emission scanning electron microscopy (FESEM) and attenuated total reflectance (ATR)-Fourier transform infrared (FTIR) and water contact angle measurement were used to validate the effectiveness of introduction of SF/VEGF. The result of ELISA demonstrated that the release of VEGF was well maintained up to 4 weeks. The modified UHMWPE was evaluated by both in vitro and in vivo experiments. According to the results of FESEM and cell counting kit-8 (CCK-8) assay, bone marrow mesenchymal stem cells cultured on the UHMWPE coated with SF/VEGF and SF exhibited a better proliferation performance than that of the pristine UHMWPE. The model rabbit of anterior cruciate ligament reconstruction was used to observe the graft–bone healing process in vivo. The results of histological evaluation, microcomputed tomography (micro-CT) analysis, and biomechanical tests performed at 6 and 12 weeks after surgery demonstrated that graft–bone healing could be significantly improved due to the effect of VEGF on angiogenesis, which was loaded on the surface by SF coating. This study showed that the method loading VEGF on UHMWPE by SF coating played an effective role on the biological performance of UHMWPE and displayed a great potential application for anterior cruciate ligament reconstruction.

show abstract

“…Plasma treatments allow surface modification of polymeric materials without altering their bulk properties [20][21][22]. These plasma processes can be categorized into 3 major types of reaction: plasma activation, post-irradiation grafting (briefly discussed in the next sections), and plasma polymerization (the focus of this chapter).…”

Section: Plasma Modification Of Surfacesmentioning

confidence: 99%

Plasma Polymerization for Tissue Engineering Purposes

Aziz¹,

Ghobeira²,

Morent³

2018

Recent Research in Polymerization

View full text Add to dashboard Cite

The ability of non-equilibrium plasmas to modify surfaces has been known for many years. And a promising way to perform surface modifications without altering the bulk properties is plasma polymerization since this technique is versatile and can be applied to a wide range of materials. Plasma polymer films usually show good biocompatibility when compared to classical biomaterials. The possible biomedical use of plasma polymers motivates the study of their behavior during storage and in aqueous environment. Therefore, it is of major importance to understand the change of properties of these plasma polymers over time and when in contact with certain fluids. Recently, plasma polymer gradients (surfaces that display a change in at least one physicochemical property over distance) have attracted significant attention from the biomedical filed where the interaction of cells with a material surface is of major interest. This chapter discusses biomaterial functionalization via plasma polymerization focusing on their use in the biomedical field as well as their aging and stability behaviors. Plasma polymer gradients as valuable tools to investigate cell-surface interactions will also be reviewed.

show abstract

The interplay of plasma treatment and gold coating and ultra-high molecular weight polyethylene: On the cytocompatibility

Cited by 9 publications

References 42 publications

Physicochemical and Biological Activity Analysis of Low-Density Polyethylene Substrate Modified by Multi-Layer Coatings Based on DLC Structures, Obtained Using RF CVD Method

Physicochemical and Biological Activity Analysis of Low-Density Polyethylene Substrate Modified by Multi-Layer Coatings Based on DLC Structures, Obtained Using RF CVD Method

Surface modification of vascular endothelial growth factor-loaded silk fibroin to improve biological performance of ultra-high-molecular-weight polyethylene via promoting angiogenesis

Plasma Polymerization for Tissue Engineering Purposes

Contact Info

Product

Resources

About