Midazolam impairs the retrieval of conditioned taste aversion via opioidergic transmission in mice

Yasoshima, Yasunobu; Shimura, Tsuyoshi

doi:10.1016/j.neulet.2016.10.055

Cited by 7 publications

(7 citation statements)

References 33 publications

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“…Baseline drinking time was higher in taCasp-lesioned mice relative to control mice, consistent with their increased responding and higher breakpoint in the operant task. As previously reported (35), LiCl injection significantly reduced sucrose consumption in control mice (50.3 ± 11.1% decrease from baseline). However, mice with taCasp lesions of glutamatergic VP neurons showed no change in sucrose consumption following LiCl injection (31.4 ± 9.4% nonsignificant change) (Figure 7G).…”

Section: Resultssupporting

confidence: 89%

“…Whole-brain scanning was used to detect monosynaptic inputs to glutamatergic VP neurons labeled with pseudorabies virus conjugated to green fluorescent protein (GFP) (Figure 3A). The number of GFP-positive cells was quantified in each upstream brain region [according to the atlas of Paxinos and Franklin (35)], and the number of GFP-positive cells in each brain area was expressed as a proportion of the total GFP-positive cells quantified across all brain regions (Figure 3B). The VP is the primary output of the NAc (36).…”

Section: Resultsmentioning

confidence: 99%

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Glutamatergic Ventral Pallidal Neurons Modulate Activity of the Habenula–Tegmental Circuitry and Constrain Reward Seeking

Tooley

Marconi

Alipio

et al. 2018

Biological Psychiatry

128

152

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Section: Resultssupporting

confidence: 89%

Section: Resultsmentioning

confidence: 99%

Glutamatergic Ventral Pallidal Neurons Modulate Activity of the Habenula–Tegmental Circuitry and Constrain Reward Seeking

Tooley

Marconi

Alipio

et al. 2018

Biological Psychiatry

128

152

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“…The effect of antegrade amnesia, combined with opioids, etomidate, propofol drugs can produce synergistic or additive effects, resulting in analgesic effect (17). However, the use of midazolam can accumulate in patients with renal failure, and some patients may also develop drug resistance; while the excessive injection dose or use may cause blood pressure drop or respiratory depression in patients with hypovolemia (18). Dexmedetomidine is a highly selective novel α2 adrenergic receptor agonist with a specific pharmacological effect (19).…”

Section: Discussionmentioning

confidence: 99%

Effect of dexmedetomidine anesthesia on perioperative levels of TNF-α and IL-6 in patients with ovarian cancer

Liu

Zhao

2019

Oncol Lett

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Effect of continuous use of dexmedetomidine during general anesthesia on perioperative levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in patients undergoing radical resection of ovarian cancer was investigated. The initial treatment of ovarian cancer is mainly radical surgery. Most patients with ovarian cancer radical surgery can achieve good results, but the use of improper anesthetic drugs in radical surgery can easily lead to unstable patient vital signs. Therefore, the selection of appropriate anesthetic drugs has become the key to radical ovarian cancer surgery. There are few reports on the use of dexmedetomidine in anesthesia for ovarian cancer radical surgery. This study was performed to retrospectively analyze the case data of patients undergoing laparoscopic ovarian cancer radical surgery, and to compare the hemodynamics of dexmedetomidine anesthesia with midazolam anesthesia and the concentrations of TNF-α and IL-6, to provide reference for clinical implementation of ovarian cancer radical surgery. The hemodynamics of patients in the dexmedetomidine group were stable compared with the midazolam group. Serum TNF-α and IL-6 levels were significantly lower in the dexmedetomidine group than that in the midazolam group. If dexmedetomidine were continuously used during general anesthesia, the perioperative serum levels of TNF-α and IL-6 could be effectively reduced in patients undergoing radical resection of ovarian cancer, and the perioperative stress response was suppressed.

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“…To address the role of LC NE neurons in memory retrieval, we conducted selective activation of these neurons using INTENS and investigated its impact on the retrieval process of conditioned taste aversion, in which animals learn an association between a taste stimulus and a visceral malaise-inducing stimulus ( Bermúdez-Rattoni, 2004; Yamamoto et al, 1994 ). We used a taste reactivity test, which is a sensitive marker of taste aversion ( Inui et al,2013; Yasoshima and Shimura, 2017 ) ( Figure 3A for the behavioral procedure and Figure 3B for the experimental apparatus). In this paradigm, taste aversion memory was formed by repeated conditioning, in which the voluntary consumption of 0.5 M sucrose as a conditioned stimulus (CS) was followed by intraperitoneal 0.15 M lithium chloride (LiCl) injection (2% of body weight) as an unconditioned stimulus (US).…”

Section: Resultsmentioning

confidence: 99%

“…Taste reactivity test was carried out as described ( Inui et al, 2013; Yasoshima and Shimura, 2017 ) with some modifications. Mice were anesthetized with 1.5% isoflurane and, surgically, bilaterally implanted with 26-gauge guide cannulae (Plastics One) into the LC using the coordinates (mm) AP −0.9, ML +0.6 and DV −2.3 from lambda or dura according to the brain atlas ( Franklin and Paxinos, 2008 ).…”

Section: Methodsmentioning

confidence: 99%

Enhanced aversive memory retrieval by chemogenetic activation of locus coeruleus norepinephrine neurons

Fukabori

Iguchi

Kato

et al. 2019

Preprint

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The ability to retrieve memory store in response to the environment is 1 essential for animal behavioral adaptation. Norepinephrine (NE)-containing neurons in 2 the brain play a key role in the modulation of synaptic plasticity underlying various 3 processes of memory formation. However, the role of the central NE system in memory 4 retrieval remains unclear. In this study we developed a neural chemogenetic activation 5 strategy using insect olfactory Ionotropic Receptors (IRs), which we used it for selective 6 stimulation of NE neurons in the locus coeruleus (LC) in transgenic mice. 7 Ligand-induced activation of LC NE neurons resulted in enhancement of the retrieval 8 process of conditioned taste aversion, which was mediated through at least partly 9 adrenergic receptors in the amygdala. Pharmacological blockade of LC activity 10 confirmed the facilitative role of these neurons in memory retrieval. Our findings 11 indicate that the LC-amygdalar pathway is required and sufficient for enhancing the 12 recall of taste associative memory. 13 14 National Academy of Sciences of the United States of America 111:5584-5592. DOI: 1 https://doi.org/10.1073/pnas.1421304111 2 Kempadoo KA, Mosharov EV, Choi SJ, Sulzer D, Kandel ER. 2016. Dopamine release 3 from the locus coeruleus to the dorsal hippocampus promotes spatial learning and 4 memory. Klein SB, Nichols S. 2012. Memory and the sense of personal identity. Mind 7 121:677-702.

show abstract

Midazolam impairs the retrieval of conditioned taste aversion via opioidergic transmission in mice

Cited by 7 publications

References 33 publications

Glutamatergic Ventral Pallidal Neurons Modulate Activity of the Habenula–Tegmental Circuitry and Constrain Reward Seeking

Glutamatergic Ventral Pallidal Neurons Modulate Activity of the Habenula–Tegmental Circuitry and Constrain Reward Seeking

Effect of dexmedetomidine anesthesia on perioperative levels of TNF-α and IL-6 in patients with ovarian cancer

Enhanced aversive memory retrieval by chemogenetic activation of locus coeruleus norepinephrine neurons

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