Cross-talk among immune and neuroendocrine systems in molluscs and other invertebrate models

Malagoli, Davide; Ottaviani, Enzo

doi:10.1016/j.yhbeh.2016.10.015

Cited by 17 publications

(8 citation statements)

References 27 publications

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“…Interestingly, some immune proteins were related to neurological system process in both compartments. While the nervous system of invertebrates is poorly studied, Malagoli and Ottaviani [26] evidenced a strong complementarity between the nervous system and immune system of mollusc species.…”

Section: Gene Ontology Analysis Of the Immune Proteomementioning

confidence: 99%

The immune system of the freshwater zebra mussel, Dreissena polymorpha, decrypted by proteogenomics of hemocytes and plasma compartments

Leprêtre

Almunia

Armengaud

et al. 2019

Journal of Proteomics

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Section: Gene Ontology Analysis Of the Immune Proteomementioning

confidence: 99%

The immune system of the freshwater zebra mussel, Dreissena polymorpha, decrypted by proteogenomics of hemocytes and plasma compartments

Leprêtre

Almunia

Armengaud

et al. 2019

Journal of Proteomics

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“…Moreover, the basic investigation of the hemocyte/hemolymph system represents a simplified phylogenetic model for understanding the ancestral interactions and integrations that occur between immunity and neuroendocrine response [85] and, more generally, between defense mechanisms and host homeostasis.…”

Section: Defense Mechanisms In Marine Bivalve Mollusksmentioning

confidence: 99%

Microbial Diseases of Bivalve Mollusks: Infections, Immunology and Antimicrobial Defense

et al. 2017

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A variety of bivalve mollusks (phylum Mollusca, class Bivalvia) constitute a prominent commodity in fisheries and aquacultures, but are also crucial in order to preserve our ecosystem’s complexity and function. Bivalve mollusks, such as clams, mussels, oysters and scallops, are relevant bred species, and their global farming maintains a high incremental annual growth rate, representing a considerable proportion of the overall fishery activities. Bivalve mollusks are filter feeders; therefore by filtering a great quantity of water, they may bioaccumulate in their tissues a high number of microorganisms that can be considered infectious for humans and higher vertebrates. Moreover, since some pathogens are also able to infect bivalve mollusks, they are a threat for the entire mollusk farming industry. In consideration of the leading role in aquaculture and the growing financial importance of bivalve farming, much interest has been recently devoted to investigate the pathogenesis of infectious diseases of these mollusks in order to be prepared for public health emergencies and to avoid dreadful income losses. Several bacterial and viral pathogens will be described herein. Despite the minor complexity of the organization of the immune system of bivalves, compared to mammalian immune systems, a precise description of the different mechanisms that induce its activation and functioning is still missing. In the present review, a substantial consideration will be devoted in outlining the immune responses of bivalves and their repertoire of immune cells. Finally, we will focus on the description of antimicrobial peptides that have been identified and characterized in bivalve mollusks. Their structural and antimicrobial features are also of great interest for the biotechnology sector as antimicrobial templates to combat the increasing antibiotic-resistance of different pathogenic bacteria that plague the human population all over the world.

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“…In molluscs, increased nociceptive sensitivity is also induced by signals from activated immune cells [6,7]. Local connections between immune cells and neurons support regeneration and repair in vertebrates and invertebrates [8] and are probably evolutionarily ancient [9]. The increase in nociceptor sensitivity in animals also leads to behavioural changes that are thought to promote healing (e.g.…”

Section: Introductionmentioning

confidence: 99%

Listening to your gut: immune challenge to the gut sensitizes body wall nociception in the caterpillarManduca sexta

Adamo

McMillan

2019

Phil. Trans. R. Soc. B

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Immune–nociceptor connections are found in animals across phyla. Local inflammation and/or damage results in increased nociceptive sensitivity of the affected area. However, in mammals, immune responses far from peripheral nociceptors, such as immune responses in the gut, produce a general increase in peripheral nociceptive sensitivity. This phenomenon has not, to our knowledge, been found in other animal groups. We found that consuming heat-killed pathogens reduced the tactile force needed to induce a defensive strike in the caterpillar Manduca sexta . This increase in the nociceptive sensitivity of the body wall is probably part of the reconfiguration of behaviour and physiology that occurs during an immune response (e.g. sickness behaviour). This increase may help enhance anti-predator behaviour as molecular resources are shifted towards the immune system. This article is part of the Theo Murphy meeting issue ‘Evolution of mechanisms and behaviour important for pain’.

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Cross-talk among immune and neuroendocrine systems in molluscs and other invertebrate models

Cited by 17 publications

References 27 publications

The immune system of the freshwater zebra mussel, Dreissena polymorpha, decrypted by proteogenomics of hemocytes and plasma compartments

The immune system of the freshwater zebra mussel, Dreissena polymorpha, decrypted by proteogenomics of hemocytes and plasma compartments

Microbial Diseases of Bivalve Mollusks: Infections, Immunology and Antimicrobial Defense

Listening to your gut: immune challenge to the gut sensitizes body wall nociception in the caterpillarManduca sexta

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