Platelet-rich plasma: a biomimetic approach to enhancement of surgical wound healing

Fernandez-Moure, Joseph; Eps, Jeffrey L. Van; Cabrera, Fernando; Barbosa, Zonia; Rosal, Guillermo Medrano del; Weiner, Bradley K.; Ellsworth, Warren A.; Tasciotti, Ennio

doi:10.1016/j.jss.2016.08.063

Cited by 70 publications

(59 citation statements)

References 96 publications

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“…Some of the results from treatment of chronic wounds with PRP [107–109] are similar to those we have discussed in relation to local application of rFXIII in CVLU [95]. Thus far, there have been no reports, at least to our knowledge, about the FXIII-A content of PRP or its contribution to the effects of PRP.…”

Section: Future Perspectives For Fxiii-a In the Field Of Dermatologysupporting

confidence: 66%

“…Platelet-rich plasma (PRP) is widely used for its beneficial effects in wound healing and rejuvenation via multiple actions, as it contains several different types of molecules such as growth factors and cytokines [107]. Some of the results from treatment of chronic wounds with PRP [107–109] are similar to those we have discussed in relation to local application of rFXIII in CVLU [95].…”

Section: Future Perspectives For Fxiii-a In the Field Of Dermatologymentioning

confidence: 86%

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Factor XIII Subunit A in the Skin: Applications in Diagnosis and Treatment

Paragh

Törőcsik

2017

BioMed Research International

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The role of factor XIII subunit A (FXIII-A) is not restricted to hemostasis. FXIII-A is also present intracellularly in several human cells and serves as a diagnostic marker in a wide range of dermatological diseases from inflammatory conditions to malignancies. In this review, we provide a guide on the still controversial interpretation of dermal cell types expressing FXIII-A and assess the previously described mechanisms behind their accumulation under physiological and pathological conditions of the human skin. We summarize the intracellular functions of FXIII-A as well as its possible sources in the extracellular space of the dermis with a focus on its relevance to skin homeostasis and disease pathogenesis. Finally, the potential role of FXIII-A in wound healing, as a field with long-term therapeutic implications, is also discussed.

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Section: Future Perspectives For Fxiii-a In the Field Of Dermatologysupporting

confidence: 66%

Section: Future Perspectives For Fxiii-a In the Field Of Dermatologymentioning

confidence: 86%

Factor XIII Subunit A in the Skin: Applications in Diagnosis and Treatment

Paragh

Törőcsik

2017

BioMed Research International

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“…There is a growing consensus for the positive effects of PRP as an adjuvant therapy to aid the healing of surgical wounds and injuries. In fact, the growth factors present in PRP are involved in every stage of wound healing [71][72][73] , and several reviews [74][75][76][77][78] , systematic reviews [79][80][81] , and clinical studies [82][83][84] have reported their involvement in enhanced soft-tissue healing outcomes. Our results did not show statistically significant differences in the SWAS scores between the groups because they both obtained the best possible score.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of platelet-rich plasma as an adjuvant to surgical carpal ligament release: a prospective, randomized controlled clinical trial

Trull-Ahuir

Sala

Chismol-Abad

et al. 2020

Sci Rep

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The purpose of this study is to evaluate the efficiency of local platelet-rich plasma (PRP) injection as an adjuvant treatment after carpal ligament release. We conducted a prospective randomized, tripleblinded, controlled trial. Fifty participants with mild to extreme carpal tunnel syndrome (CTS) were randomly assigned either to the PRP (n = 25) or the platelet-poor plasma (PPP, n = 25) group. After performing open surgical release of the carpal ligament, the inside of the carpal tunnel was irrigated with 3 mL of PRP or PPP according to each participant's group allocation. The primary outcome was hand grip strength (HGS). Secondary outcomes were the time taken off work after surgery (in days) and scores on the Wong-Baker Faces Scale, Boston Carpal Tunnel Questionnaire, and Southampton Wound Assessment Scale. We evaluated patients before treatment and at 6-weeks. As expected, the pain levels, symptom severity, and functional status improved in all the patients after surgery. However, intragroup analysis revealed that only the participants in the PRP group had regained their pre-operative HGS levels at 6-weeks follow-up. These findings indicate that PRP is an effective adjuvant treatment in patients with mild to severe CTS who require surgery. Carpal tunnel syndrome (CTS), which affects approximately 3% of the general adult population 1 , is the most commonly diagnosed upper limb peripheral entrapment neuropathy 2. CTS is characterized by compression of the median nerve (MN) at the wrist as it passes through the carpal tunnel 3 and typical symptoms include numbness, paresthesias, and pain in areas innervated by the MN. In more severe cases, weakness and atrophy of the thenar muscles (innervated by the MN) can occur which in turn, usually affects the work productivity and quality of life of the affected patient 4-6. Depending on the severity of the symptoms, treatments for CTS may be conservative (including the use of medications, a night splint, steroid injections, or physical therapy) or require surgical intervention. Surgical decompression of the carpal tunnel by transection of the transverse carpal ligament is the standard treatment for patients with muscle atrophy, or whose symptoms do not respond to conservative therapies 2,7. Carpal tunnel decompression is a well-established surgical treatment for CTS whose reported success rate and levels of patient satisfaction are high 8. Nonetheless, this technique is not exempt from potential complications including: sensitive scar areas, persistent symptoms, neurovascular injury, wound complications, bleeding, pillar pain (pain adjacent to the ligament release site), and reduced grip strength 9,10. Therefore, adjuvant surgical treatments are worth exploring. Platelet-rich plasma (PRP) is an autologous blood product comprising concentrated platelets and several growth factors (including transforming growth factor-β, platelet-derived growth factor, epidermal growth factor, vascular endothelial growth factor, insulin-like growth factor-1, fibroblast growth factor, hepatoc...

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“…Additionally, there is not a precise consensus regarding platelet-rich plasma production and characterization. This lack of consensus also prevents a standard approach in the PRP [1][2][3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“…Platelets: origin, structure, distribution, and their roles in hemostasis Platelets, discovered in the nineteenth century, are small, nucleus-free cytoplasmic cellular structures which are round or oval-shaped and have about 2 μm diameter and derived from megakaryocytes (a type of white blood cell) in the bone marrow [1]. These cellular structures were initially believed to be involved only in the hemostasis and pathological thrombus formation.…”

Section: Introductionmentioning

confidence: 99%

Platelet-Rich Plasma in Burn Treatment

Ünal¹

2018

Hot Topics in Burn Injuries

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As a general definition, platelet-rich plasma (PRP) is the concentration of autologous human platelets in a small amount of plasma. PRP contains important growth factors deposited in alpha-granules of platelets and plasma proteins such as fibrin, fibronectin, and vitronectin. PRP has been shown to improve wound healing process in acute trauma wounds, incisional wounds, and chronic nonhealing wounds and is a beneficial agent in reconstructions of soft and hard tissue. Furthermore, PRP enhances differentiation of epithelial cell and collagen bundle organization. Effects of growth factors in PRP on wound healing and successful results obtained with PRP treatment in other types of wound lead to the use of PRP for burn treatment.

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Platelet-rich plasma: a biomimetic approach to enhancement of surgical wound healing

Cited by 70 publications

References 96 publications

Factor XIII Subunit A in the Skin: Applications in Diagnosis and Treatment

Factor XIII Subunit A in the Skin: Applications in Diagnosis and Treatment

Efficacy of platelet-rich plasma as an adjuvant to surgical carpal ligament release: a prospective, randomized controlled clinical trial

Platelet-Rich Plasma in Burn Treatment

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