Design of Magnetic Polymeric Particles as a Stimulus-Responsive System for Gastric Antimicrobial Therapy

Silva-Freitas, Érica Lira; Pontes, Thales Renan Ferreira; Araújo-Neto, Rafael P.; Damasceno, Ítalo H. M.; Silva, Kátia L.; Carvalho, José Ferreira de; Medeiros, Aldo Cunha; Silva, Rodolfo Bezerra da; Silva, Amanda; Morales, Marco A.; Egito, Eryvaldo Sócrates Tabosa do; Dantas, Ana L.; Carriço, A. S.

doi:10.1208/s12249-016-0673-1

Cited by 17 publications

(8 citation statements)

References 50 publications

(11 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A dual pH- and magnetic field-responsive magnetite coated with Eudragit ® S100 was fabricated and loaded with amoxicillin. In vitro studies demonstrated its usefulness as an antibacterial agent [ 188 ].…”

Section: Stimuli-responsive Polymeric Nanocarriers For Drug and Gmentioning

confidence: 99%

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

et al. 2020

View full text Add to dashboard Cite

In the past few decades, polymeric nanocarriers have been recognized as promising tools and have gained attention from researchers for their potential to efficiently deliver bioactive compounds, including drugs, proteins, genes, nucleic acids, etc., in pharmaceutical and biomedical applications. Remarkably, these polymeric nanocarriers could be further modified as stimuli-responsive systems based on the mechanism of triggered release, i.e., response to a specific stimulus, either endogenous (pH, enzymes, temperature, redox values, hypoxia, glucose levels) or exogenous (light, magnetism, ultrasound, electrical pulses) for the effective biodistribution and controlled release of drugs or genes at specific sites. Various nanoparticles (NPs) have been functionalized and used as templates for imaging systems in the form of metallic NPs, dendrimers, polymeric NPs, quantum dots, and liposomes. The use of polymeric nanocarriers for imaging and to deliver active compounds has attracted considerable interest in various cancer therapy fields. So-called smart nanopolymer systems are built to respond to certain stimuli such as temperature, pH, light intensity and wavelength, and electrical, magnetic and ultrasonic fields. Many imaging techniques have been explored including optical imaging, magnetic resonance imaging (MRI), nuclear imaging, ultrasound, photoacoustic imaging (PAI), single photon emission computed tomography (SPECT), and positron emission tomography (PET). This review reports on the most recent developments in imaging methods by analyzing examples of smart nanopolymers that can be imaged using one or more imaging techniques. Unique features, including nontoxicity, water solubility, biocompatibility, and the presence of multiple functional groups, designate polymeric nanocues as attractive nanomedicine candidates. In this context, we summarize various classes of multifunctional, polymeric, nano-sized formulations such as liposomes, micelles, nanogels, and dendrimers.

show abstract

Section: Stimuli-responsive Polymeric Nanocarriers For Drug and Gmentioning

confidence: 99%

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Hybrid strategies for targeting the IME include, dual endogenous stimuli-responsive nanosystems (pH/enzyme) 55,56 and endo/exogeneous stimuli-responsive nano-systems, which utilize pH/magnetic 53 , pH/PTT 61 , enzyme/PTT 67 and enzyme/US 69 triggers. The codelivery of an antibiotic and an anti-inflammatory agent to the site of infection was proposed as a novel strategy for sepsis therapy, to diminish the bacteria and the inflammation response simultaneously.…”

Section: Complex Hybrid Triggered Nano-systemsmentioning

confidence: 99%

Recent Advances in Combating Bacterial Infections by Using Hybrid Nano-systems

Patel¹,

Hunt²

2023

Preprint

View full text Add to dashboard Cite

In recent years, antimicrobial resistance in many human pathogens has become a serious health concern. Since infections with resistant pathogens cannot be treated with traditional antimicro-bial drugs, new strategies are necessary to fight bacterial infections. Hybrid nano-systems may provide a solution to this problem, by combining multiple mechanisms for killing bacteria to synergistically increase the effectiveness of the antimicrobial treatment. In this review, we high-light recent advances in the development of hybrid nano-systems for the treatment of bacterial infections. We discuss the use of hybrid nano-systems for combinational therapy, focusing on various triggering mechanisms for drug release and the development of biomimetic nanomateri-als. We also examine inherently antimicrobial nano-systems and their uses in preventing infec-tions due to wounds and medical implants. This review summarizes recent advances and pro-vides insight into the future development of antimicrobial treatments using hybrid nanomateri-als.

show abstract

“…Since not all implants are conductive, the alternative utilization of magnetic field and pH activation proposed in ref. [181] can be also considered as the very perspective way. Finally, the combination of other stimuli, like light and supramolecular host-guest chemical interaction, was also reported [182], and further progress in this field can be expected.…”

Section: Physico-chemical Stimulationmentioning

confidence: 99%

Physically Switchable Antimicrobial Surfaces and Coatings: General Concept and Recent Achievements

et al. 2021

View full text Add to dashboard Cite

Bacterial environmental colonization and subsequent biofilm formation on surfaces represents a significant and alarming problem in various fields, ranging from contamination of medical devices up to safe food packaging. Therefore, the development of surfaces resistant to bacterial colonization is a challenging and actively solved task. In this field, the current promising direction is the design and creation of nanostructured smart surfaces with on-demand activated amicrobial protection. Various surface activation methods have been described recently. In this review article, we focused on the “physical” activation of nanostructured surfaces. In the first part of the review, we briefly describe the basic principles and common approaches of external stimulus application and surface activation, including the temperature-, light-, electric- or magnetic-field-based surface triggering, as well as mechanically induced surface antimicrobial protection. In the latter part, the recent achievements in the field of smart antimicrobial surfaces with physical activation are discussed, with special attention on multiresponsive or multifunctional physically activated coatings. In particular, we mainly discussed the multistimuli surface triggering, which ensures a better degree of surface properties control, as well as simultaneous utilization of several strategies for surface protection, based on a principally different mechanism of antimicrobial action. We also mentioned several recent trends, including the development of the to-detect and to-kill hybrid approach, which ensures the surface activation in a right place at a right time.

show abstract

Design of Magnetic Polymeric Particles as a Stimulus-Responsive System for Gastric Antimicrobial Therapy

Cited by 17 publications

References 50 publications

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

Recent Advances in Combating Bacterial Infections by Using Hybrid Nano-systems

Physically Switchable Antimicrobial Surfaces and Coatings: General Concept and Recent Achievements

Contact Info

Product

Resources

About