Parasitological and molecular surveys reveal high rates of infection with vector-borne pathogens and clinical anemia signs associated with infection in cattle from two important livestock areas in Colombia

Jaimes-Dueñez, Jeiczon; Triana-Chávez, Omar; Mejía-Jaramillo, Ana María

doi:10.1016/j.ttbdis.2016.12.002

Cited by 35 publications

(29 citation statements)

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“…The results reported herein demonstrate that in the study area, the two Babesia species exhibited differences in prevalence between the mammalian hosts studied, with B. bigemina being most prevalent in cattle (24.2%) and B. bovis in buffaloes (17.7%). Similar results were observed in livestock areas from Argentina, Brazil and Colombia, in which the molecular prevalence of B. bigemina and B. bovis in cattle was 46.4 ± 7.0% and 11.7 ± 3.6%, respectively [ 10 , 18 , 38 – 40 ], while in buffaloes it was 8.6 ± 7.6% and 17.5 ± 8.8% for each species, respectively [ 41 – 43 ]. These findings, together with those obtained from the spatio-temporal analysis, in which these proportions did not vary with time (Fig.…”

Section: Discussionsupporting

confidence: 77%

“…Thus, the active infection rate detected by molecular methods in cattle under six months old (> 60%) together with the lack of anemic signs associated (Fig. 3a ), suggest an enzootic stability in this population, as observed in other livestock areas from Colombia [ 10 , 12 , 49 ]. However, future studies using serological test are necessary to confirm the enzootic stability in the study area.…”

Section: Discussionsupporting

confidence: 52%

“…Babesia bigemina and B. bovis are the two economically important species affecting livestock farms involved in dairy and beef production in Colombia [ 1 , 10 , 12 ]. Given the paucity of studies on the distribution and characterization of these pathogens in different mammalian hosts, control strategies have been unsuccessful.…”

Section: Discussionmentioning

confidence: 99%

“…Previous parasitological surveys of Babesia spp. carried out in these regions showed a prevalence of 1.1–3.8% in cattle [ 8 – 10 ], and 4.6–30.1% in buffaloes [ 11 , 12 ], suggesting an important role of the latter host in maintaining the circulation of these pathogens. In Colombia the buffalo population is increasing with an annual growth up to 35%, most of them bred in the same pastures alongside the cattle [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Molecular surveillance and phylogenetic traits of Babesia bigemina and Babesia bovis in cattle (Bos taurus) and water buffaloes (Bubalus bubalis) from Colombia

et al. 2018

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BackgroundBabesia bigemina and B. bovis are two economically important hemoparasites affecting both cattle and buffaloes involved in dairy and beef production. In Colombia, although some parasitological and serological studies suggest an endemicity of these pathogens in areas under 1000 m, little is known about its molecular prevalence in different host. The objective of this study was to estimate the prevalence and molecular traits of these parasites in cattle and buffaloes from two Colombian regions.MethodsBetween 2014 and 2016, a three-point longitudinal survey was designed in farms from Caribbean and Orinoquia regions to evaluate the molecular prevalence of B. bigemina and B. bovis using a nested PCR (n-PCR) targeting hypothetical protein (hyp) and rhoptry-associated protein (RAP-1) genes, respectively. A total of 1432 cattle, 152 buffalo and 1439 Rhipicephalus microplus samples were analyzed. Moreover, phylogenetic relationship of isolates was analyzed using the 18S rRNA gene.ResultsA molecular prevalence of 31.6% (24.2% for B. bigemina and 14.4% for B. bovis), 23.6% (6.5% for B. bigemina and 17.7% for B. bovis) and 4.3% (3.5% for B. bigemina and 1.0% for B. bovis) was observed in cattle, buffaloes and Rhipicephalus microplus, respectively. Higher values of infection were observed during the wet season and late wet season; nevertheless, other variables such as age, production type, sex, breed and babesiosis control were also significantly associated with infection. Prevalence analysis showed that B. bovis infection was higher in cattle that coexist with buffaloes, when compared to those which did not. For each species, phylogenetic analyses revealed a high genetic diversity of isolates without clusters related to the isolation source.ConclusionsTo our knowledge, this is the first longitudinal survey that evaluates through molecular methods, the infection of B. bigemina and B. bovis in two important livestock regions from Colombia. This study reveals that the prevalence of infection by Babesia spp., in cattle and buffaloes are modulated by seasonal variations, host factors and vector traits. Our results provide new insights on the epidemiological aspects of infection of Babesia spp., in cattle and buffaloes, which must be taken into consideration when babesiosis control programs are implemented in the study area.Electronic supplementary materialThe online version of this article (10.1186/s13071-018-3091-2) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Molecular surveillance and phylogenetic traits of Babesia bigemina and Babesia bovis in cattle (Bos taurus) and water buffaloes (Bubalus bubalis) from Colombia

et al. 2018

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“…These results are inconsistent with reports by Máttar & Parra (28), who reported the first evidence of A. phagocytophilum in the department of Córdoba in 81 workers evaluated, with seroprevalence of 20%. (28) Nevertheless, the results of a study conducted by Jaimes-Duenez et al (29), using molecular methods, showed a prevalence of 59.3% (n=275) for Anaplasma spp. in cattle in the municipalities of Necoclí and Turbo in the department of Antioquia, which proves the circulation of these microorganisms in productive livestock systems.…”

Section: Discussionmentioning

confidence: 99%

Occupational history of exposure to zoonotic agents in people dedicated to livestock in San Pedro de los Milagros, Antioquia, Colombia

et al. 2019

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Introduction: According to the World Health Organization, livestock farming is one of the anthropic activities in which workers are exposed to various zoonotic agents.Objectives: To establish the frequency of seropositivity (IgG antibodies) against some zoonotic agents in people with occupational exposure to livestock in San Pedro de los Milagros (Antioquia), and to analyze associated factors.Materials and methods: Descriptive study carried out on a population of 328 cattle farmers. Demographic data were collected and the seropositivity frequency of IgG antibodies to Babesia bovis, Babesia bigemina, Anaplasma phagocytophilum, Ehrlichia chaffensis, Borrelia burgdorferi, Coxiella burnetii, Francisella tularensis, Brucella abortus, Brucella suis, Leptospira interrogans, and Toxoplasma gondii was determined. Overall and specific prevalence, prevalence ratios and binary logistic regressions were estimated.Results: The highest seropositivity frequencies were 47.6% for T. gondii, 33.5% for B. burgdorferi and 13% for E. chaffensis. The prevalence of T. gondii and B. burgdorferi had statistical association with sex [RP:1.3 (CI:1.0-1.8) and 2.0 (CI:1.1-3.9) respectively], and age group [(RP:1.5 (CI:1.2-1,9) and 2.5 (CI:1.4-6.4) respectively]. In workers with more than 10 years of related work experience, statistical association was 50% [RP:1.5 (CI:1.2-1.9) and 2.5 (CI:1.6-2.3), respectively]. There were no seropositive results for B. abortus, B. suis, B. bovis and B. bigemina.Conclusions: Exposure to some zoonotic agents was evidenced. This is determinant for the knowledge of tropical zoonotic diseases transmitted by vectors in livestock production systems.

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Hemoparasitism in grazing cattle and risk factors associated with husbandry management in an endemic area of Eastern Colombia

Mor,

Tavera,

Tobón

et al. 2024

J Parasit Dis

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Vector-borne pathogens induce hemoparasitism in cattle causing substantial economic losses in tropical and subtropical areas. Infectious cattle actively contribute to maintaining the transmission cycle, and the presence of these animals must be associated with husbandry management and environmental changes. In the present study, we conducted a cross-sectional study sampling 1,000 bovines to identify infectious cattle diagnosed by a direct technique and employed a dichotomic questionnaire for association analyses, hierarchical clustering, and Principal Component Analysis (PCA). Overall prevalence with infectious cattle was 34.99%, where 97% of the farms had at least one infectious animal per genera, and the prevalence in properties ranged between 16.39 and 53.85%. Of these animals, 26.20% tested positive for Anaplasma sp., 8.40% for Babesia spp., and 1.30% for Trypanosome spp. The main co-infection showed 5% Anaplasma sp. – Trypanosome spp., followed by 4% Babesia spp. – Trypanosome spp. These bovines showed association with the use of the Jersey breed (OR = 2.016 C.I:1.188–3.419), selling animals for replacement (OR = 1.417 CI:1.022–1.965), participation in livestock exhibitions (OR = 2.009 CI:1.262–3.199), premises with burials (OR = 2,064 CR: 1.414–3.011), use of palm kernel (OR = 1.935 C.I:1.198–3.124), and the use of ivermectin (OR = 1.548 CI: 1.085–2.210) as a susceptibility. The hierarchical clustering revealed clusters among properties with different hemoparasite prevalence, with notable co-infections observed. The subsequent PCA identified that significant risk factors contributed to hemoparasitism positivity. We conclude that infectious cattle in the endemic area showed an association with husbandry management that permits the success of vector and maintenance of the enzootic or epizootic cycle in the herds.

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Parasitological and molecular surveys reveal high rates of infection with vector-borne pathogens and clinical anemia signs associated with infection in cattle from two important livestock areas in Colombia

Cited by 35 publications

References 42 publications

Molecular surveillance and phylogenetic traits of Babesia bigemina and Babesia bovis in cattle (Bos taurus) and water buffaloes (Bubalus bubalis) from Colombia

Molecular surveillance and phylogenetic traits of Babesia bigemina and Babesia bovis in cattle (Bos taurus) and water buffaloes (Bubalus bubalis) from Colombia

Occupational history of exposure to zoonotic agents in people dedicated to livestock in San Pedro de los Milagros, Antioquia, Colombia

Hemoparasitism in grazing cattle and risk factors associated with husbandry management in an endemic area of Eastern Colombia

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