A comprehensive meta‐analysis on dietary flavonoid and lignan intake and cancer risk: Level of evidence and limitations

Grosso, Giuseppe; Godos, Justyna; Lamuela‐Raventós, Rosa María; Ray, Sumantra; Micek, Agnieszka; Pająk, Andrzej; Sciacca, Salvatore; D’Orazio, Nicolantonio; Rio, Daniele Del; Galvano, Fabio

doi:10.1002/mnfr.201600930

Cited by 223 publications

(150 citation statements)

References 31 publications

(39 reference statements)

Supporting

Mentioning

143

Contrasting

Unclassified

Order By: Relevance

“…They are usually provided to the food as color, flavor, bitter, and astringent, and maintain stability from oxidation. Several epidemiological studies and associated meta-analyses strongly showed that the consumption of these polyphenols offered better protection against chronic diseases such as cancers, cardiovascular diseases, cerebrovascular diseases, diabetes, ageing and neurodegenerative diseases [2,3,4,5]. …”

Section: Polyphenolsmentioning

confidence: 99%

A Critical Review on Polyphenols and Health Benefits of Black Soybeans

Ganesan

2017

Nutrients

227

View full text Add to dashboard Cite

Polyphenols are plant secondary metabolites containing antioxidant properties, which help to protect chronic diseases from free radical damage. Dietary polyphenols are the subject of enhancing scientific interest due to their possible beneficial effects on human health. In the last two decades, there has been more interest in the potential health benefits of dietary polyphenols as antioxidant. Black soybeans (Glycine max L. Merr) are merely a black variety of soybean containing a variety of phytochemicals. These phytochemicals in black soybean (BSB) are potentially effective in human health, including cancer, diabetes, cardiovascular diseases, cerebrovascular diseases, and neurodegenerative diseases. Taking into account exploratory study, the present review aims to provide up-to-date data on health benefit of BSB, which helps to explore their therapeutic values for future clinical settings. All data of in vitro and in vivo studies of BSB and its impact on human health were collected from a library database and electronic search (Science Direct, PubMed, and Google Scholar). The different pharmacological information was gathered and orchestrated in a suitable spot on the paper.

show abstract

Section: Polyphenolsmentioning

confidence: 99%

A Critical Review on Polyphenols and Health Benefits of Black Soybeans

Ganesan

2017

Nutrients

227

View full text Add to dashboard Cite

show abstract

“…Epidemiological studies have shown associations between a diet rich in polyphenols and the prevention of human diseases [12,17,18,19,20,21]. Polyphenols are natural anti-oxidants present in the human diet.…”

Section: Polyphenolsmentioning

confidence: 99%

Effects of Polyphenols on Oxidative Stress-Mediated Injury in Cardiomyocytes

et al. 2017

View full text Add to dashboard Cite

Cardiovascular diseases are the main cause of mortality and morbidity in the world. Hypertension, ischemia/reperfusion, diabetes and anti-cancer drugs contribute to heart failure through oxidative and nitrosative stresses which cause cardiomyocytes nuclear and mitochondrial DNA damage, denaturation of intracellular proteins, lipid peroxidation and inflammation. Oxidative or nitrosative stress-mediated injury lead to cardiomyocytes apoptosis or necrosis. The reactive oxygen (ROS) and nitrogen species (RNS) concentration is dependent on their production and on the expression and activity of anti-oxidant enzymes. Polyphenols are a large group of natural compounds ubiquitously expressed in plants, and epidemiological studies have shown associations between a diet rich in polyphenols and the prevention of various ROS-mediated human diseases. Polyphenols reduce cardiomyocytes damage, necrosis, apoptosis, infarct size and improve cardiac function by decreasing oxidative stress-induced production of ROS or RNS. These effects are achieved by the ability of polyphenols to modulate the expression and activity of anti-oxidant enzymes and several signaling pathways involved in cells survival. This report reviews current knowledge on the potential anti-oxidative effects of polyphenols to control the cardiotoxicity induced by ROS and RNS stress.

show abstract

“…Daily consumption of (poly)phenols has been related to reduction of inflammation, hypertension, risk of cardiovascular, metabolic, neurodegenerative diseases, and cancer [18,19,20,21,22]. An essential part of the scientific research in vivo is represented by the investigation of the absorption, metabolism and bioavailability of (poly)phenolic compounds after human intake.…”

Section: Introductionmentioning

confidence: 99%

Absorption Profile of (Poly)Phenolic Compounds after Consumption of Three Food Supplements Containing 36 Different Fruits, Vegetables, and Berries

et al. 2017

Self Cite

View full text Add to dashboard Cite

The market of plant-based nutraceuticals and food supplements is continuously growing due to the increased consumer demand. The introduction of new products with relevant nutritional characteristics represents a new way of providing bioactive compounds and (poly)phenols to consumers, becoming a strategy to ideally guarantee the health benefits attributed to plant foodstuffs and allowing the increase of daily bioactive compound intake. A paramount step in the study of nutraceuticals is the evaluation of the bioavailability and metabolism of their putatively active components. Therefore, the aim of the present study was to investigate the absorption profile of the (poly)phenolic compounds contained in three different plant-based food supplements, made of 36 different plant matrices, which were consumed by 20 subjects in an open one-arm study design. Blood samples were collected at baseline and 1, 2, 5, and 10 h after capsule intake. Twenty quantifiable metabolites deriving from different (poly)phenolic compounds were identified. Results showed that the consumption of the three capsules allowed the effective absorption of several (poly)phenolic compounds and metabolites appearing at different times in plasma, thereby indicating different absorption profiles. The capsules thus ensured potential health-promoting molecules to be potentially available to target tissues and organs.

show abstract

A comprehensive meta‐analysis on dietary flavonoid and lignan intake and cancer risk: Level of evidence and limitations

Cited by 223 publications

References 31 publications

A Critical Review on Polyphenols and Health Benefits of Black Soybeans

A Critical Review on Polyphenols and Health Benefits of Black Soybeans

Effects of Polyphenols on Oxidative Stress-Mediated Injury in Cardiomyocytes

Absorption Profile of (Poly)Phenolic Compounds after Consumption of Three Food Supplements Containing 36 Different Fruits, Vegetables, and Berries

Contact Info

Product

Resources

About