White collar rhabdomyolysis with acute kidney injury

Bhakthavatsalam, RK; Venu, G; Raju, P Arjun; C, Madhusudan H

doi:10.4103/0971-4065.177209

Cited by 2 publications

(3 citation statements)

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“…The continuous muscle contractions compromise capillary blood flow. [ 11 ] In a large case series of persons with near drowning in the Mediterranean Sea, features of rhabdomyolysis were detected in most patients due to muscle hypoxia and the strenuous physical exercise in their struggle to stay alive. [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Etiological Spectrum and Histopathological Diagnosis of Rhabdomyolysis Associated Myoglobin Cast Nephropathy in South India

Prema¹,

Kurien²

2021

Indian J Nephrol

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Background and Aims: Rhabdomyolysis occurs due to injury to skeletal muscle fibers and the release of muscle constituents into the circulation. Myoglobin cast nephropathy leading to acute kidney injury is one of the most severe complications of rhabdomyolysis. This is a retrospective study which aims to analyse the clinicopathological features of myoglobin cast nephropathy. Methods: A total of 57 cases of myoglobin cast nephropathy were identified after performing immunohistochemical staining for myoglobin on all renal biopsies with pigment casts. The clinical, laboratory data, histopathological findings and clinical outcome of these cases were evaluated. Results: The mean patient age was 34.47 years (range 17-77) and the male to female ratio was 6.1:1. All patients presented with acute kidney injury with mean serum creatinine of 8.4 mg/dl (range: 1.7 to 20.8 mg/dl). Rhabdomyolysis was clinically suspected only in 31 patients. Along with myoglobin casts, acute tubular injury was present in all the biopsies. The most frequent conditions associated with myoglobin cast nephropathy in our study were snake envenomation and unaccustomed physical activities. A few activities that caused rhabdomyolysis in our patients were unique to India. Conclusion: Clinicians should be aware of the wide spectrum of causes for rhabdomyolysis. The classical clinical and laboratory findings of rhabdomyolysis may not be present in many of the patients. The pathologist must have a high index of suspicion, and immunohistochemical stain should be used to confirm the diagnosis.

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Section: Discussionmentioning

confidence: 99%

Etiological Spectrum and Histopathological Diagnosis of Rhabdomyolysis Associated Myoglobin Cast Nephropathy in South India

Prema¹,

Kurien²

2021

Indian J Nephrol

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“…HIIRT had similar effects in both men and women, except for SCr and UNGAL. There are no prospective studies on the effects of resistance exercises on renal function available for comparison, but case reports of resistance exercises associated-AKI, including severe dialysis-dependent AKI and renal histology showing acute tubular necrosis after high-intensity resistance exercises have been described [ 11 , 16 ]. The limitations of this study are that we analyzed a single HIIRT session and had a short follow-up time.…”

Section: Discussionmentioning

confidence: 99%

“…Nonetheless, although moderate-intensity exercises are safe, strenuous and high-intensity exercises may cause unfavorable effects, including rhabdomyolysis and acute kidney injury (AKI), and they may be deleterious to long-term health outcomes, especially in poorly trained or sedentary individuals [ 3 ]. In fact, case reports of severe rhabdomyolysis, with and without AKI, associated with different modalities of high-intensity exercises have recently been published [ 11 – 13 ].…”

Section: Introductionmentioning

confidence: 99%

High intensity resistance training causes muscle damage and increases biomarkers of acute kidney injury in healthy individuals

et al. 2018

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PurposeHigh-intensity interval resistance training (HIIRT) is an increasingly popular exercise program that provides positive results with short sessions. This study aimed to evaluate whether an HIIRT session causes muscle and kidney damage.MethodsFifty-eight healthy volunteers (median age 24 years, 50% women) participated in this study and performed a HIIRT session. The Borg CR10 scale for pain (CR10P) and blood and urine samples were collected before (baseline) and 2 and 24 hours after the HIIRT session. Blood samples were analyzed for serum creatinine (SCr), creatine kinase (CK) and myoglobin. Urine samples were assessed for creatinine, neutrophil gelatinase-associated lipocalin, interleukin 18, calbindin, microalbuminuria, trefoil factor-3 and β-2 microglobulin.ResultsCR10P had a significant increase at 2 and 24 hours post-workout, and CK increased significantly at 2 hours and increased further at 24 hours. Myoglobin increased significantly at 2 hours and remained elevated at 24 hours. SCr increased modestly but significantly at 24 hours only in men. Three men met the KDIGO diagnostic criteria for acute kidney injury. The urinary kidney injury biomarkers increased significantly at 2 hours and returned to the baseline values 24 hours after HIIRT.ConclusionsA single HIIRT session caused early and significant elevations in CK, myoglobin, SCr, microalbuminuria and urinary biomarkers indicative of kidney tubular injury, suggesting the occurrence of muscle and kidney damage.

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White collar rhabdomyolysis with acute kidney injury

Cited by 2 publications

References 12 publications

Etiological Spectrum and Histopathological Diagnosis of Rhabdomyolysis Associated Myoglobin Cast Nephropathy in South India

Etiological Spectrum and Histopathological Diagnosis of Rhabdomyolysis Associated Myoglobin Cast Nephropathy in South India

High intensity resistance training causes muscle damage and increases biomarkers of acute kidney injury in healthy individuals

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