Genetic polymorphisms of<i>UTS2</i>rs2890565 Ser89Asn in cardiac hypertrophy in Chinese Han population

Zhao, Jing; Jiang, Jie; Wang, Jie; Li, Lin; Han, Xiaoning; Chu, Song-Yun; Xue, Liyan; Ding, Wenyuan

doi:10.1136/postgradmedj-2016-134476

Cited by 3 publications

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References 27 publications

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“…CHD is a complex polygenic genetic disease affected by genetic factors. At present, several gene SNPs have been found to be associated with CHD risk, such as UTS2 (Ser89Asn) [ 18 ], CDKN2B-AS1 (rs10738606) [ 1 ], GLUT4 (rs5418) [ 19 ], CYP11B1 (rs4534, rs6410 and rs5283) [ 20 ], CYP24A1 (rs6068816 and rs2296241) [ 21 ] and AGT (rs2493132) [ 22 ]. Considering that the connection of CYP4V2 polymorphisms with CHD risk has not been reported, five SNPs (rs1398007, rs13146272, rs3736455, rs1053094 and rs56413992) in CYP4V2 gene were eventually genotyped in this study and their association with CHD risk were explored.…”

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confidence: 99%

CYP4V2 rs56413992 C > T was associated with the risk of coronary heart disease in the Chinese Han population: a case–control study

Huang,

Ma,

et al. 2023

BMC Med Genomics

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Purpose The research aimed to detect the association between single nucleotide polymorphisms (SNPs) in CYP4V2 gene and coronary heart disease (CHD) risk. Methods This case–control study included 487 CHD subjects and 487 healthy individuals. Logistic regression was performed to analyze the connection between five SNPs in CYP4V2 (rs1398007, rs13146272, rs3736455, rs1053094, and rs56413992) and CHD risk, and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the connection. Results As a result, we found that rs56413992 T allele (OR = 1.36, 95% CI = 1.09–1.70, p = 0.007) and CT genotype (OR = 1.40, 95% CI = 1.06–1.83, p = 0.017) were significantly associated with an increased risk of CHD in the overall analysis. Precisely, rs56413992 was linked to an elevated risk of CHD in people aged > 60, males, smokers and drinkers. The study also indicated that rs1398007 was linked to an increased CHD risk in drinkers. In addition, rs1053094 was correlated with a decreased risk of CHD complicated with diabetes mellitus (DM), and rs1398007 was correlated with a decreased risk of CHD complicated with hypertension (HTN). Conclusion This study was the first to experimentally demonstrate that CYP4V2 rs56413992 was associated with the risk of CHD, which will provide a certain reference for revealing the pathogenesis of CHD.

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