Effect of exercise on the development of new fatty liver and the resolution of existing fatty liver

Kim, Hyun-seok; Ike, Adaugo; Mathew, Justin

doi:10.1016/j.jhep.2016.11.024

Cited by 4 publications

(2 citation statements)

References 20 publications

(19 reference statements)

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“…Exercise should be considered as a drug for intervention of NAFLD (41). Measurement of liver fat and physical activity in 169,347 participants from a recent study demonstrated a strong association between exercise and amelioration of hepatic steatosis in NAFLD (42). More notably, aerobic exercise provided a beneficial effect on liver function in NAFLD without weight loss (43).…”

Section: Discussionmentioning

confidence: 99%

Long‐term exercise prevents hepatic steatosis: a novel role of FABP1 in regulation of autophagy‐lysosomal machinery

Pi¹,

Liu²,

Chen³

et al. 2019

The FASEB Journal

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Nonalcoholic fatty liver disease (NAFLD) is one of the most prevalent diseases worldwide. Exercise is a first‐line therapy and an important preventive measure for patients with NAFLD, but the underlying mechanisms are not clear. C57BL/6 mice were fed a high‐fat diet (HFD) and subjected to 12 wk swimming exercise. Exercise protected against hepatic lipid accumulation and alleviated hepatocyte damage in HFD mice. Tandem mass tag—based quantitative proteomic analyses and ingenuity pathway analysis revealed that exercise down‐regulated fatty acid‐binding protein (FABP) 1 signaling pathway, which was most closely associated with lipid metabolism. Moreover, exercise significantly decreased FABP1 expression, and liver‐specific overexpression of FABP1 abolished the protective effect of exercise in NAFLD mice. Specifically, exercise significantly increased autophagic flux via restoring lysosomal function, including lysosomal proteolysis and lysosomal acidification maintenance, contributing to enhancement in autophagic clearance and subsequently alleviation of hepatic steatosis. Conversely, Fabp1 overexpression in the mouse liver blocked the protective effect of exercise via inhibiting autophagy flux. The present study identified FABP1 inhibition‐mediated replenishment of the autophagy‐lysosomal machinery as a novel endogenous mechanism whereby long‐term exercise improves lipid homeostasis and ameliorates hepatic steatosis in NAFLD.—Pi, H., Liu, M., Xi, Y., Chen, M., Tian, L., Xie, J., Chen, M., Wang, Z., Yang M., Yu, Z., Zhou, Z., Gao, F. Long‐term exercise prevents hepatic steatosis: a novel role of FABP1 in regulation of autophagy‐lysosomal machinery. FASEB J. 33, 11870‐11883 (2019). http://www.fasebj.org

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Section: Discussionmentioning

confidence: 99%

Long‐term exercise prevents hepatic steatosis: a novel role of FABP1 in regulation of autophagy‐lysosomal machinery

Pi¹,

Liu²,

Chen³

et al. 2019

The FASEB Journal

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“…According to numerous references, fatty liver can be reversed, especially when the patients adhere to a proper exercise program, dietary recommendations, and/or appropriate medications [ 1 ]. It has been reported that adopting exercise therapy in an effort to ultimately stop medication may be a more scientific and ideal way to treat fatty liver [ 2 , 3 ]. In the current study, an exercise prescription was initiated to probe into the rehabilitation concept of exercise prescription intervention for fatty liver patients, and suggestions on standardized rehabilitation were advanced, which are summarized as follows.…”

Section: Introductionmentioning

confidence: 99%

Exercise Prescription Intervention Rehabilitation Suggestions for Fatty Liver Patients

Wan

Hong

2022

Evidence-Based Complementary and Alternative Medicine

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In this study, the exercise prescription intervention rehabilitation suggestions for fatty liver patients were summarized as follows: first, basic exercises (brisk walking and jogging.), sports (swimming, badminton, and cycling), traditional Chinese medicine exercises (Taichi boxing and eight-section brocade), the aim of which is to improve overall physical strength and endurance of the body; second, exercise intensity, duration, and frequency; third, exercise precautions; and fourth, exercise prescription selection and suggestion.

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MicroRNAs Mediate Beneficial Effects of Exercise in Heart

Bei

Tao

Crețoiu

et al. 2017

Advances in Experimental Medicine and Biology

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MicroRNAs (miRNAs, miRs), a group of small non-coding RNAs, repress gene expressions at posttranscriptional level in most cases and are involved in cardiovascular physiology and disease pathogenesis. Increasing evidence has proved that miRNAs are potential regulators of exercise induced cardiac growth and mediate the benefits of exercise in a variety of cardiovascular diseases. In this chapter, we will review the regulatory effects of miRNAs in cardiac adaptations to exercise, and summarize their cardioprotective effects against myocardial infarction, ischemia/reperfusion injury, heart failure, diabetic cardiomyopathy, atherosclerosis, hypertension, and pulmonary hypertension. Also, we will introduce circulating miRNAs in response to acute and chronic exercise. Therefore, miRNAs may serve as novel therapeutic targets and potential biomarkers for cardiovascular diseases.

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Effect of exercise on the development of new fatty liver and the resolution of existing fatty liver

Cited by 4 publications

References 20 publications

Long‐term exercise prevents hepatic steatosis: a novel role of FABP1 in regulation of autophagy‐lysosomal machinery

Long‐term exercise prevents hepatic steatosis: a novel role of FABP1 in regulation of autophagy‐lysosomal machinery

Exercise Prescription Intervention Rehabilitation Suggestions for Fatty Liver Patients

MicroRNAs Mediate Beneficial Effects of Exercise in Heart

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