Risk factors and outcomes of high peritonitis rate in continuous ambulatory peritoneal dialysis patients

Tian, Yuanshi; Xie, Xueping; Xiang, Shilong; Yang, Xin; Zhang, Xiaohui; Shou, Zhangfei; Chen, Jianghua

doi:10.1097/md.0000000000005569

Cited by 32 publications

(29 citation statements)

References 32 publications

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“…[5] Risk factors for PD-related peritonitis are older age, diabetes, hypoalbuminemia, and invasive procedures including hysteroscopy, dental procedures, and colonoscopy. [5][6][7][8][9] As most gut microorganisms are found in the colon, the gut is a potential source of intra-abdominal infection. [10] Several studies have reported the development of peritonitis after colonoscopy in patients on PD.…”

Section: Introductionmentioning

confidence: 99%

Risk factors for peritonitis in patients on continuous ambulatory peritoneal dialysis who undergo colonoscopy: A retrospective multicentre study

Gweon

Jung

Kim

et al. 2019

Preprint

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Background: Colonoscopy is associated with a risk of peritonitis in patients on peritoneal dialysis. However, no study has yet described the risk factors in play. Methods: This was a retrospective multicentre study. The medical records of patients on continuous ambulatory peritoneal dialysis (CAPD) who underwent colonoscopy from January 2003 to December 2012 were analysed. We recorded demographic characteristics, colonoscopic factors, use of prophylactic antibiotics, and development of peritonitis. Colonoscopy-related peritonitis was defined as peritonitis developing within 1 week after colonoscopy. Demographic and clinical characteristics were compared between patients who did and those who did not develop peritonitis. Results: During the study period, 236 patients on CAPD underwent colonoscopy, of whom 9 (3.8%) developed peritonitis. The rates of polypectomy/endoscopic mucosal resection were significantly higher in the peritonitis group than in the no peritonitis group (66.7 vs. 23.4%, p=0.009). Prophylactic antibiotics were prescribed before colonoscopy in 65 patients; none developed peritonitis. No patient who developed peritonitis received prophylactic antibiotics (p=0.067). Conclusions: Advanced procedures including polypectomy or endoscopic mucosal resection increase colonoscopy-related peritonitis in patients on CAPD. Prophylactic antibiotics should be administered before colonoscopy to such patients.

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Section: Introductionmentioning

confidence: 99%

Risk factors for peritonitis in patients on continuous ambulatory peritoneal dialysis who undergo colonoscopy: A retrospective multicentre study

Gweon

Jung

Kim

et al. 2019

Preprint

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“…Tian et al found a similar distribution of peritonitis cases. They assessed gram-positive bacteria as the reason of the first peritonitis in 39.1% cases; only 17% of first peritonitis were gram-negative in the origin, while 40% of peritonitis were culture-negative [3]. In our study in 2012 and 2014 gram-positive bacteria were dominant as peritonitis reason (64.7% and 66.7% respectively), while in the last two years of the study the percentage of gram-negative peritonitis was rising up to 33.3% in 2015, and to 37.5% in 2016.…”

Section: Discussionmentioning

confidence: 99%

“…Despite progress in dialysis treatment technique, peritoneal-related peritonitis is up to now a serious infectious complication of peritoneal dialysis (PD) [1]. Catheter loss or the patient's death are the most serious after-effects of peritonitis [2,3]. The quick and appropriate diagnosis of peritonitis symptoms is needed to avoid its complications.…”

Section: Introductionmentioning

confidence: 99%

Retrospective single-center analysis of the reasons and serious complications of peritoneal-related peritonitis in patients with end-stage renal disease undergoing peritoneal dialysis treatment

Grzebalska

Steć

Ławnicka

et al. 2018

Polish Journal of Public Health

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Introduction. Peritonitis is still a serious complication of peritoneal dialysis (PD). Consequences of peritonitis can be severe. The most severe are peritoneal dialysis discontinuation and patient’s death. In majority, peritonitis is bacterial in the origin. Mainly there is a gram-positive infection, less commonly gram-negative one. Some peritonitis are culture-negative, because of former antibiotics use. In minority, fungal, tuberculous or even viral peritonitis are observed. Aim. The aim of the present study is to analyze the number, origin and serious complications of peritoneal-related peritonitis cases found in our PD center. Material and methods. We performed a retrospective five-years evaluation of medical records. The total number of peritonitis episodes was 56 cases, underwent by 30 adult patients on chronic peritoneal dialysis. Peritonitis was diagnosed according to ISPD recommendations. Causes and serious complications of peritoneal-related peritonitis were analyzed in every single year. Etiology of peritonitis was classified on the basis of the result of effluent dialysate culture as: gram-positive, gram-negative and culture negative. Peritoneal dialysis discontinuation or patient’s death were defined as serious complications. Results. Among 56 cases of peritoneal-related peritonitis 44.6% were gram-positive, 26.8% gram-negative and 28.6% culture-negative. No fungal or tuberculosis peritonitis were found. Because of the peritonitis complications in the evaluated period, six patients discontinued peritoneal dialysis and were switched to hemodialysis (20%), two others died (6.7%). Conclusion. The further improvement in peritonitis’ causes identification and treatment is needed in order to reduce number of serious complications in our medical center.

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“…Furthermore, Tian et al reported that they had 31 patients die among 2917 CAPD patients during the study period from 2002 to 2014 and that the most common causes of CAPD-related death were cerebrovascular disease (29.0%) and infection (19.4%) [3]. They also found similar common pathogens, such as Gram-positive bacteria followed by Gram-negative bacteria in CAPD peritonitis Here, we report a case of definite Mycobacterium abscessus associated peritonitis in a woman on CAPD treated by linezolid (LZD) and tedizolid (TZD) in addition to clarithromycin (CAM).…”

Section: Introductionmentioning

confidence: 99%

Mycobacterium abscessus Associated Peritonitis with CAPD Successfully Treated Using a Linezolid and Tedizolid Containing Regimen Suggested Immunomodulatory Effects

et al. 2020

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Objective: Rare disease Background: Mycobacterium abscessus is one of the most important mycobacteria, but its associated peritonitis in patients on continuous ambulatory peritoneal dialysis (CAPD) appears relative rare, and the treatment regimen of the antibiotics are still unclear. Case Report: A 38-year-old female with chronic glomerulonephritis on CAPD who was diagnosed with M. abscessus-associated peritonitis. Symptoms exacerbated despite treatment with a 3-antibiotic regimen combining clarithromycin, imipenem/cilastatin (IPM/CS), and minocycline (MINO). However, after changing IPM/CS and MINO to linezolid (LZD), her condition and inflammation improved, and she was able to be maintained on oral tedizolid (TZD). Conclusions: Oxazolidinones such as LZD and TZD might be candidate antibiotics for the treatment of M. abscessus-associated diseases with chronic renal failure due to their immunomodulatory effects and non-renal excretion.

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Risk factors and outcomes of high peritonitis rate in continuous ambulatory peritoneal dialysis patients

Abstract: Supplemental Digital Content is available in the text

Cited by 32 publications

References 32 publications

Risk factors for peritonitis in patients on continuous ambulatory peritoneal dialysis who undergo colonoscopy: A retrospective multicentre study

Risk factors for peritonitis in patients on continuous ambulatory peritoneal dialysis who undergo colonoscopy: A retrospective multicentre study

Retrospective single-center analysis of the reasons and serious complications of peritoneal-related peritonitis in patients with end-stage renal disease undergoing peritoneal dialysis treatment

Mycobacterium abscessus Associated Peritonitis with CAPD Successfully Treated Using a Linezolid and Tedizolid Containing Regimen Suggested Immunomodulatory Effects

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