7T MR of intracranial pathology: Preliminary observations and comparisons to 3T and 1.5T

Obusez, Emmanuel C.; Lowe, Mark J.; Oh, Se Hong; Wang, Irène; Bullen, Jennifer; Ruggieri, Paul; Hill, Virginia; Lockwood, Daniel; Emch, Todd; Moon, Doksu; Loy, Gareth; Lee, Jonathan K.; Kiczek, Matthew; Massand, Manoj G; Statsevych, Volodymyr; Stultz, Todd W.; Jones, Stephen E.

doi:10.1016/j.neuroimage.2016.11.030

Cited by 84 publications

(63 citation statements)

References 52 publications

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“…In mTLE, the hippocampus is considered as a central core of abnormalities and is often structurally damaged (e.g., de Campos et al, ). Even in the case of the so‐called cryptogenic epilepsy or MRI‐negative epilepsy, subtle lesions at the histological examination can be found (Bernasconi, Bernasconi, Bernhardt, & Schrader, ) and may sometimes be observed by using an ultrahigh‐field 7‐T (7 T) MRI (Obusez et al, ). In this study, we specifically found negative correlations across groups of patients between the size of the hippocampus involved in the epilepsy and the integration capacity of this region (Figure S4).…”

Section: Discussionmentioning

confidence: 99%

Hubs disruption in mesial temporal lobe epilepsy. A resting‐state fMRI study on a language‐and‐memory network

Roger

Pichat

Torlay

et al. 2019

Human Brain Mapping

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Mesial temporal lobe epilepsy (mTLE) affects the brain networks at several levels and patients suffering from mTLE experience cognitive impairment for language and memory. Considering the importance of language and memory reorganization in this condition, the present study explores changes of the embedded languageand-memory network (LMN) in terms of functional connectivity (FC) at rest, as measured with functional MRI. We also evaluate the cognitive efficiency of the reorganization, that is, whether or not the reorganizations support or allow the maintenance of optimal cognitive functioning despite the seizure-related damage.Data from 37 patients presenting unifocal mTLE were analyzed and compared to 48 healthy volunteers in terms of LMN-FC using two methods: pairwise correlations (region of interest [ROI]-to-ROI) and graph theory. The cognitive efficiency of the LMN-FC reorganization was measured using correlations between FC parameters and language and memory scores. Our findings revealed a large perturbation of the LMN hubs in patients. We observed a hyperconnectivity of limbic areas near the dysfunctional hippocampus and mainly a hypoconnectivity for several cortical regions remote from the dysfunctional hippocampus. The loss of FC was more important in left mTLE (L-mTLE) than in right (R-mTLE) patients. The LMN-FC reorganization may not be always compensatory and not always useful for patients as it may be associated with lower cognitive performance. We discuss the different connectivity patterns obtained and conclude that interpretation of FC changes in relation to neuropsychological scores is important to determine cognitive efficiency, suggesting the concept of "connectome" would gain to be associated with a "cognitome" concept. K E Y W O R D S brain plasticity, functional connectivity, graph theory, language, memory, mesial temporal lobe epilepsy, resting-state fMRI

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Section: Discussionmentioning

confidence: 99%

Hubs disruption in mesial temporal lobe epilepsy. A resting‐state fMRI study on a language‐and‐memory network

Roger

Pichat

Torlay

et al. 2019

Human Brain Mapping

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“…In recent years, ultrahigh‐field MRI has been used to elucidate novel insights into the pathology of neurological and neuropsychiatric diseases ex vivo . These findings have led to a growing number of in vivo studies performed at 7T, for which increased resolution of structural and functional scans has led to enhanced visualization of microstructures and novel networks of brain connectivity, enabling insights into the pathology of a range of neurological diseases . However, achieving both high SNR and high resolution requires long scan times.…”

Section: Introductionmentioning

confidence: 99%

A within‐coil optical prospective motion‐correction system for brain imaging at 7T

DiGiacomo

Maclaren

Aksoy

et al. 2020

Magnetic Resonance in Med

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Purpose: Motion artifact limits the clinical translation of high-field MR. We present an optical prospective motion correction system for 7 Tesla MRI using a custombuilt, within-coil camera to track an optical marker mounted on a subject. Methods: The camera was constructed to fit between the transmit-receive coils with direct line of sight to a forehead-mounted marker, improving upon prior mouthpiece work at 7 Tesla MRI. We validated the system by acquiring a 3D-IR-FSPGR on a phantom with deliberate motion applied. The same 3D-IR-FSPGR and a 2D gradient echo were then acquired on 7 volunteers, with/without deliberate motion and with/ without motion correction. Three neuroradiologists blindly assessed image quality.In 1 subject, an ultrahigh-resolution 2D gradient echo with 4 averages was acquired with motion correction. Four single-average acquisitions were then acquired serially, with the subject allowed to move between acquisitions. A fifth single-average 2D gradient echo was acquired following subject removal and reentry. Results: In both the phantom and human subjects, deliberate and involuntary motion were well corrected. Despite marked levels of motion, high-quality images were produced without spurious artifacts. The quantitative ratings confirmed significant improvements in image quality in the absence and presence of deliberate motion across both acquisitions (P < .001). The system enabled ultrahigh-resolution visualization of the hippocampus during a long scan and robust alignment of serially acquired scans with interspersed movement. Conclusion: We demonstrate the use of a within-coil camera to perform optical prospective motion correction and ultrahigh-resolution imaging at 7 Tesla MRI. The 1662 | DIGIACOMO et Al.

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“…Over the past few years, ultra‐high‐field (UHF) 7T MRI machines have been available in a few research centers for in vivo human brain imaging. The increased signal‐to‐noise ratio, improved spatial structural resolution, and enhanced image contrast allow for better depiction, characterization, and visualization of millimetric anatomical structures and lesions such as FCD than 3T that offers the chance to reveal new features of neurological diseases that may change clinical diagnosis . Among sequences specifically designed for higher magnetic fields, magnetization‐prepared two rapid acquisition gradient echoes (MP2RAGE) is a 3‐dimensional T1‐weighted sequence with strong contrast between gray and white matter and minimal effect of B1 inhomogeneity.…”

Section: Introductionmentioning

confidence: 99%

“…The increased signalto-noise ratio, improved spatial structural resolution, and enhanced image contrast allow for better depiction, characterization, and visualization of millimetric anatomical structures and lesions such as FCD 9-11 than 3T that offers the chance to reveal new features of neurological diseases that may change clinical diagnosis. 12 Among sequences specifically designed for higher magnetic fields, magnetization-prepared two rapid acquisition gradient echoes (MP2RAGE) is a 3-dimensional T1-weighted 13 sequence with strong contrast between gray and white matter and minimal effect of B1 inhomogeneity. A study of 31 patients encompassing a mix of neurological diseases showed an improved diagnostic confidence principally because of higher spatial resolution and contrast at 7T as compared to 3T.…”

Section: Introductionmentioning

confidence: 99%

MP2RAGE and Susceptibility‐Weighted Imaging in Lesional Epilepsy at 7T

Pittau

Baud

Jorge

et al. 2018

Journal of Neuroimaging

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7T MR of intracranial pathology: Preliminary observations and comparisons to 3T and 1.5T

Cited by 84 publications

References 52 publications

Hubs disruption in mesial temporal lobe epilepsy. A resting‐state fMRI study on a language‐and‐memory network

Hubs disruption in mesial temporal lobe epilepsy. A resting‐state fMRI study on a language‐and‐memory network

A within‐coil optical prospective motion‐correction system for brain imaging at 7T

MP2RAGE and Susceptibility‐Weighted Imaging in Lesional Epilepsy at 7T

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