Hearing impairment and risk of Alzheimer’s disease: a meta-analysis of prospective cohort studies

Zheng, Yuqiu; Fan, Shengnuo; Liao, Wang; Fang, Wenli; Xiao, Shifu; Liu, Jun

doi:10.1007/s10072-016-2779-3

Cited by 73 publications

(65 citation statements)

References 37 publications

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“…Beyond the well-known negative effects of ARHL on communication, quality of life, physical functioning, and psychosocial status, ARHL has also been linked to cognitive decline. For example, large-scale epidemiological studies indicate a strong association between ARHL and risk for mild cognitive impairment and dementia, as well as accelerated decline in cognitive function over time (Lin, 2011;Lin et al, 2011;Thompson et al, 2017;Wei et al, 2017;Zheng et al, 2017;Ford et al, 2018;Loughrey et al, 2018). Though a lack of strong evidence on the long-term protective effects of clinical treatment of hearing loss on cognitive function exists, hearing loss is a potentially modifiable risk factor for cognitive decline (Livingston et al, 2017), warranting further investigation from a public health perspective (President's Council of Advisors on Science and Technology [PCAST], 2015; National Academies of Sciences Engineering and Medicine [NASEM], 2016).…”

Section: Introductionmentioning

confidence: 99%

Cortical Neuroplasticity and Cognitive Function in Early-Stage, Mild-Moderate Hearing Loss: Evidence of Neurocognitive Benefit From Hearing Aid Use

Glick

Sharma

2020

Front. Neurosci.

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Age-related hearing loss (ARHL) is associated with cognitive decline as well as structural and functional brain changes. However, the mechanisms underlying neurocognitive deficits in ARHL are poorly understood and it is unclear whether clinical treatment with hearing aids may modify neurocognitive outcomes. To address these topics, cortical visual evoked potentials (CVEPs), cognitive function, and speech perception abilities were measured in 28 adults with untreated, mild-moderate ARHL and 13 agematched normal hearing (NH) controls. The group of adults with ARHL were then fit with bilateral hearing aids and re-evaluated after 6 months of amplification use. At baseline, the ARHL group exhibited more extensive recruitment of auditory, frontal, and pre-frontal cortices during a visual motion processing task, providing evidence of cross-modal re-organization and compensatory cortical neuroplasticity. Further, more extensive cross-modal recruitment of the right auditory cortex was associated with greater degree of hearing loss, poorer speech perception in noise, and worse cognitive function. Following clinical treatment with hearing aids, a reversal in cross-modal reorganization of auditory cortex by vision was observed in the ARHL group, coinciding with gains in speech perception and cognitive performance. Thus, beyond the known benefits of hearing aid use on communication, outcomes from this study provide evidence that clinical intervention with well-fit amplification may promote more typical cortical organization and functioning and provide cognitive benefit.

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Section: Introductionmentioning

confidence: 99%

Cortical Neuroplasticity and Cognitive Function in Early-Stage, Mild-Moderate Hearing Loss: Evidence of Neurocognitive Benefit From Hearing Aid Use

Glick

Sharma

2020

Front. Neurosci.

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“…from the perspective of its relation with cognition. Numerous studies, including systematic review articles and meta-analyses, have shown a link between ARHL and cognitive decline, impaired performance across cognitive domains, and increased risk for dementia diagnosis [2][3][4][5][6]. Loughrey et al analyzed the results of 36 unique studies with an estimated 20,264 unique participants based on inclusion criteria in a meta-analysis, and estimated the association between ARHL and cognitive function, cognitive impairment, and dementia.…”

mentioning

confidence: 99%

Age-related hearing loss and cognitive decline — The potential mechanisms linking the two

et al. 2019

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The amount of attention to age-related hearing loss (ARHL) has been growing, not only from the perspective of being one of the most common health conditions affecting older adults, but also from the perspective of its relation to cognition. Results from a number of epidemiological and laboratory studies have demonstrated a significant link between ARHL and cognitive decline. The Lancet International Commission on Dementia, Prevention, Intervention, and Care has estimated that mid-life hearing loss, if eliminated, might decrease the risk of dementia by nine percent, since hearing loss is a modifiable age-associated condition linked to dementia. Despite numerous research efforts, elucidation of the underlying causal relationships between auditory and cognitive decline has not yet reached a consensus. In this review article, we focused on the hypotheses of etiological mechanisms between ARHL and cognitive decline: (1) cognitive load hypothesis; (2) common cause hypothesis; (3) cascade hypothesis; and (4) overdiagnosis or harbinger hypothesis. Factual evidence obtained in previous studies was assessed to understand the link between ARHL and cognitive decline or dementia. Additionally, an overview of the conceivable effects of hearing intervention, e.g., hearing aids and cochlear implants, on cognition were presented, and the role of hearing aid use was considered for the relevant hypotheses. We should continue to strive for social enlightenment towards the importance of 'hearing well', and cultivate a necessity for hearing screening among patients at risk of cognitive decline.

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“…Hearing loss (ICD-code 389) is independently associated with lower scores on tests of memory and incidence of all-cause dementia or AD [21-23, 41, 42]. In a meta-analysis of prospective studies, Zheng et al [18] found that people with hearing impairment faced a higher risk of developing AD than did those in a control group. Several possible mechanisms have been proposed.…”

Section: Discussionmentioning

confidence: 99%

“…Pathological manifestation in head injury have also been linked to the risk of LOAD, including increased amyloid-beta and tau pathology, neuroinflammation, and axonal and cytoskeletal changes in the brain [15][16][17]. Hearing loss has been reported as a risk factor for dementia [18][19][20][21], where even mild levels suggest a link [22,23]. Patients with hearing loss may suffer from social isolation, depression, disability, and increased risk of dementia [24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Exploring prior diseases associated with incident late-onset Alzheimer’s disease dementia

et al. 2020

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Studies have identified prior conditions associated with late-onset Alzheimer's disease dementia (LOAD), but all prior diseases have rarely been screened simultaneously in the literature. Our objective in the present study was to identify prior conditions associated with LOAD and construct pathways for them. We conducted a population-based matched casecontrol study based on data collected in the National Health Insurance Research database of Taiwan and the Catastrophic Illness Certificate database for the years 1997-2013. Prior diseases definitions were based on the first three digits of the codes listed in the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM). Inclusion criteria required that each ICD-code existed for at least 1 year and incurred at least 2 outpatient visits or inpatient diagnosis. The case group comprised 4,600 patients newly diagnosed with LOAD in 2007-2013. The LOAD patients were matched by sex and age to obtain 4,600 controls. Using stepwise multivariate logistic regression analysis, diseases were screened for 1, 2. . ., 9 years prior to the first diagnosis of LOAD. Path analysis was used to construct pathways between prior diseases and LOAD. Our results revealed that the following conditions were positively associated with the incidence of LOAD: anxiety (ICD-code 300), functional digestive disorder (ICD code 564), psychopathology-specific symptoms (ICD-code 307), disorders of the vestibular system (ICD-code 386), concussion (ICD-code 850), disorders of the urethra and urinary tract (ICD-code 599), disorders of refraction and accommodation (ICD-code 367), and hearing loss (ICD-code 389). A number of the prior diseases have previously been described in the literature in a manner identical to that in the present study. Our study supports the assertion that mental, hearing, vestibular system, and functional digestive disorders may play an important role in the pathogenesis of LOAD.

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Hearing impairment and risk of Alzheimer’s disease: a meta-analysis of prospective cohort studies

Cited by 73 publications

References 37 publications

Cortical Neuroplasticity and Cognitive Function in Early-Stage, Mild-Moderate Hearing Loss: Evidence of Neurocognitive Benefit From Hearing Aid Use

Cortical Neuroplasticity and Cognitive Function in Early-Stage, Mild-Moderate Hearing Loss: Evidence of Neurocognitive Benefit From Hearing Aid Use

Age-related hearing loss and cognitive decline — The potential mechanisms linking the two

Exploring prior diseases associated with incident late-onset Alzheimer’s disease dementia

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