<i>Origanum majorana</i>Essential Oil Lacks Mutagenic Activity in the<i>Salmonella</i>/Microsome and Micronucleus Assays

Dantas, Andréa dos Santos; Klein‐Júnior, Luiz Carlos; Machado, Miriana S.; Guecheva, Temenouga Nikolova; Santos, Luciana Dalazen dos; Zanette, Régis A.; Mello, Fernanda Bastos de; Henriques, João Antônio Pêgas; Mello, João Roberto Braga de

doi:10.1155/2016/3694901

Cited by 12 publications

(3 citation statements)

References 26 publications

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“…The most abundant carvacrol component was found to be the first most abundant compound in previous studies: 84.00% [51], 78.27% [77], 75.30% [51], 40.57% [78], 34.14% [79]. In our study, the other main components, α-Terpineol [45,78,[80][81][82], p-Cymene [51,80,[83][84][85][86], α-Terpineol [45,78,[80][81][82], y-Terpinene [46,51,[77][78][79][80][81][83][84][85][86][87][88], and 1,8 Cineole [45,80,83,89,90], were in line with previous studies.…”

Section: Discussionsupporting

confidence: 64%

Phytotoxic Effects of Three Origanum Species Extracts and Essential Oil on Seed Germinations and Seedling Growths of Four Weed Species

Kordalı

Kabaagac

Şen³

et al. 2022

Agronomy

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The use of chemical pesticides to protect agricultural products is a global concern because of their adverse effects on the environment and public health. To avoid the dangers of synthetic herbicides, research has turned to natural alternatives. This study was conducted to evaluate the allelopathic effect of essential oil (EO) extracted from Origanum syriacum, Origanum onites, and Origanum majorana. In addition, the chemical composition of the essential oil was elucidated by gas chromatography and mass spectrometry (GC–MS) analysis. A total of 11 different components of O.syriacum were identified, and the main components were carvacrol (88.49), p-Cymene (5.71), γ-Terpinene (1.63), β-Caryoplhyllene (1.48), and Terpinen-4-ol (0.65), respectively. For O. onites, 10 different compounds were identified, and the main components were carvacrol (58.65), Thymol (30.97), Linalool (4.17), p-Cymene (1.94), and β-Caryoplhyllene (0.98), respectively. Finally, for O. majorana, 14 different compounds were identified, and the main components were carvacrol (40.57), α-Terpineol (29.28), p-Cymene (9.02), γ-Terpinene (5.80), and carvacrol methyl ether (3.46). Finally, 14 compounds from the Origanum majorana species were identified, with carvacrol (40.57), -Terpineol (29.28), p-Cymene (9.02), and -Terpinene (5.80) as the parent compound (3.46). Oxygenated monoterpenes were the highest in all species’ EO content. EOs and plant extracts were tested at 5, 10, and 20 L/Petri concentrations against seed germination and seedling growth in four weed species (Thlaspi arvense, Amaranthus retroflexus, Rumex cripus, and Lactuca serriola). The concentrations of essential oil were set as 5, 10, and 20 µL/Petri dishes for seed germination. In the greenhouse experiment, the final concentration of solutions was set as 20 µL and the solutions were directly sprayed on the surface of the weeds, and the mortality rates were noted after 24 and 48 h of application. It was observed that increasing the application decreased seed germination. The phytotoxic effects on the seedling germination in the greenhouse were observed, resulting in 48.76–94% mortality rates. Consequently, the essential oil from Origanum species could be considered as an alternative bio-herbicide to tested weeds.

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Section: Discussionsupporting

confidence: 64%

Phytotoxic Effects of Three Origanum Species Extracts and Essential Oil on Seed Germinations and Seedling Growths of Four Weed Species

Kordalı

Kabaagac

Şen³

et al. 2022

Agronomy

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“…Linalyl acetate (26.1%), Sabinene (12%) [44] Brazil 𝛾-Terpinene (25.73%), 𝛼-Terpinene (17.35%), Terpinen-4-ol (17.24%), Sabinene (10.8%) [45] Venezuela cis-Sabinene hydrate (30.2%), Terpinen-4-ol (28.8%), γ-Terpinene (7.2%), α-Terpineol (6.9%), trans-Sabinene hydrate (4.4%), Linalyl acetate (3.8%), α-Terpinene (3.6%)…”

Section: Iranmentioning

confidence: 99%

“…Helium was used as the carrier gas, with a constant flow rate of 1.8 mL/min. A 3% w/v solution in CH 2 Cl 2 was prepared for the essential oil sample, and 0.1 µL was injected at a split ratio of 1:45 [44,45,47]. The percentage composition of enantiomers was calculated from the peak area.…”

Section: Chiral Gc-ms Analysis For Enantiomeric Componentsmentioning

confidence: 99%

Chemical Composition, Enantiomeric Distribution, Antimicrobial and Antioxidant Activities of Origanum majorana L. Essential Oil from Nepal

Paudel

Satyal

Satyal³

et al. 2022

Molecules

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This study was conducted to examine the chemical constituents of Origanum majorana L. essential oils (EOs) that originate in Nepal, as well as their biological activities, antioxidant properties, and enantiomeric compositions. The EOs were extracted by the hydro-distillation method using a Clevenger-type apparatus and their chemical compositions were determined through gas chromatography and mass spectrometry (GC-MS). Chiral GC-MS was used to evaluate the enantiomeric compositions of EOs. The minimum inhibitory concentrations (MICs) of the essential oils were determined by the micro-broth dilution method, and the antioxidant activity was evaluated by the 2,2-diphenyl-1-picrylhydrazyl scavenging assay and ferric-reducing antioxidant power (FRAP). GC-MS analysis showed the presence of 50 and 41 compounds in the EO samples, (S1) and (S2), respectively, representing the Kathmandu and Bhaktapur districts. The oxygenated monoterpenoids, along with terpinen-4-ol, were predominant constituents in both EO samples. However, the EOs from two locations showed some variations in their major components. The chiral terpenoids for two EO samples of marjoram have also been reported in this study in an elaborative way for the first time in accordance with the literature review. A hierarchical cluster analysis based on the compositions of EOs with 50 compositions reported in the literature revealed at least 5 different chemotypes of marjoram oil. The antioxidant activity for the sample (S2) was found to be relatively moderate, with an IC50 value of 225.61 ± 0.05 μg/mL and an EC50 value of 372.72 ± 0.84 µg/mL, as compared to the standard used. Furthermore, with an MIC value of 78.1 µg/mL, the EO from sample (S2) demonstrated effective antifungal activity against Aspergillus niger and Candida albicans. Moreover, both samples displayed considerable antimicrobial activity. The results suggest that EOs of Origanum majorana possess some noteworthy antimicrobial properties as well as antioxidant activity, and hence can be used as a natural preservative ingredient in the food and pharmaceutical industries.

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Formulation characterization of lecithin organogel as topical drug delivery system for psoriasis: In‐vitro permeation and preclinical evaluation

Bule,

Kadkanje,

Kshirsagar

et al. 2024

Drug Development Research

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Psoriasis is a chronic inflammatory and proliferative skin disease that causes pathological skin changes and has a substantial impact on the quality of patient life. Apremilast was approved by the US Food and Drug Administration as an oral medication for psoriasis and is beneficial in mild to moderate conditions for chronic usage. However, 5%–7% of withdrawals were reported due to severe side effects. To address the issue, a localized drug delivery strategy via the topical route may be a viable approach. However, poor physicochemical properties make it vulnerable to passing through the skin, requiring a specialized drug delivery system to demonstrate its full potential via a topical route like lecithin organogel. The formulation was optimized by screening the suitable lecithin type and non‐polar solvents based on the gel formation ability of lecithin and the solubility of apremilast in the solvent. The pseudo‐ternary diagram was used to optimize the water content required to form the gel. The optimized gel was found to be shear thinning characterized for rheological parameters, in‐vitro diffusion studies, and in‐vitro skin distribution studies. Preclinical studies in Imiquimod‐induced mice showed a better reduction in severity index, cytokine levels, and epidermal hyperplasia from the lecithin organogel group compared to the apremilast oral administration and marketed standard topical gel group. Based on these results, lecithin organogel can be considered a promising approach to deliver molecules like apremilast by topical route in psoriatic‐like conditions.

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Origanum majoranaEssential Oil Lacks Mutagenic Activity in theSalmonella/Microsome and Micronucleus Assays

Cited by 12 publications

References 26 publications

Phytotoxic Effects of Three Origanum Species Extracts and Essential Oil on Seed Germinations and Seedling Growths of Four Weed Species

Phytotoxic Effects of Three Origanum Species Extracts and Essential Oil on Seed Germinations and Seedling Growths of Four Weed Species

Chemical Composition, Enantiomeric Distribution, Antimicrobial and Antioxidant Activities of Origanum majorana L. Essential Oil from Nepal

Formulation characterization of lecithin organogel as topical drug delivery system for psoriasis: In‐vitro permeation and preclinical evaluation

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