Expression of Alpha Methylacyl  CoA Racemase (AMACR) in Gastric  Adenocarcinoma and Its Correlation  with  Helicobacter pylori  Infection

Jindal, Yamini; Singh, Anshul; Kumar, Ravikant; Varma, Kachnar; Misra, Vatsala; Misra, Sri Prakash; Dwivedi, Manisha

doi:10.7860/jcdr/2016/19539.8721

Cited by 12 publications

(12 citation statements)

References 19 publications

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“…The SRCC is widely believed to arise from distinct biologic pathways involving genetic abnormalities in the host such as alterations of cell adherence factors like E-cadherin [ 40 , 42 ]. However, increasing epidemiological data have been also associating H. pylori infection with sporadic diffuse-type gastric cancers likely through carcinogenic pathways that are independent from gastric mucosa atrophy [ 44 , 45 , 46 , 47 , 48 , 49 ]. Several pathways probably exploited by the H. pylori to induce SRCC-like abnormalities in gastric epithelial cells have been reviewed recently [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Whole Genome Sequencing Reveals Virulence Potentials of Helicobacter pylori Strain KE21 Isolated from a Kenyan Patient with Gastric Signet Ring Cell Carcinoma

Mwangi

Njoroge

Tshibangu‐Kabamba

et al. 2020

Toxins

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Helicobacter pylori (H.pylori) infection is etiologically associated with severe diseases including gastric cancer; but its pathogenicity is deeply shaped by the exceptional genomic diversification and geographic variation of the species. The clinical relevance of strains colonizing Africa is still debated. This study aimed to explore genomic features and virulence potentials of H. pylori KE21, a typical African strain isolated from a native Kenyan patient diagnosed with a gastric cancer. A high-quality circular genome assembly of 1,648,327 bp (1590 genes) obtained as a hybrid of Illumina Miseq short reads and Oxford Nanopore MinION long reads, clustered within hpAfrica1 population. This genome revealed a virulome and a mobilome encoding more than hundred features potentiating a successful colonization, persistent infection, and enhanced disease pathogenesis. Furthermore, through an experimental infection of gastric epithelial cell lines, strain KE21 showed the ability to promote interleukin-8 production and to induce cellular alterations resulting from the injection of a functional CagA oncogene protein into the cells. This study shows that strain KE21 is potentially virulent and can trigger oncogenic pathways in gastric epithelial cells. Expended genomic and clinical explorations are required to evaluate the epidemiological importance of H. pylori infection and its putative complications in the study population.

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Section: Discussionmentioning

confidence: 99%

Whole Genome Sequencing Reveals Virulence Potentials of Helicobacter pylori Strain KE21 Isolated from a Kenyan Patient with Gastric Signet Ring Cell Carcinoma

Mwangi

Njoroge

Tshibangu‐Kabamba

et al. 2020

Toxins

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“…These findings might point to a specific elevation of peroxisomal branched-chain fatty acid metabolism in prostate tumors. Interestingly, elevated AMACR expression was also reported from colon, gastric, breast, renal and hepatocellular carcinoma (Jiang et al 2003 ; Witkiewicz et al 2005 ; Chen et al 2005 ; Went et al 2006 ; Jindal et al 2016 ) suggesting that peroxisomal branched-chain metabolism might be associated with a broader variety of tumors. In this regard, it is tempting to speculate why the degradation of branched-chain fatty acids might be elevated in prostate and other tumors.…”

Section: Peroxisomes and Cancer: A Mysterious Connectionmentioning

confidence: 95%

The peroxisome: an update on mysteries 2.0

Islinger

Voelkl

Fahimi

et al. 2018

Histochem Cell Biol

234

227

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Peroxisomes are key metabolic organelles, which contribute to cellular lipid metabolism, e.g. the β-oxidation of fatty acids and the synthesis of myelin sheath lipids, as well as cellular redox balance. Peroxisomal dysfunction has been linked to severe metabolic disorders in man, but peroxisomes are now also recognized as protective organelles with a wider significance in human health and potential impact on a large number of globally important human diseases such as neurodegeneration, obesity, cancer, and age-related disorders. Therefore, the interest in peroxisomes and their physiological functions has significantly increased in recent years. In this review, we intend to highlight recent discoveries, advancements and trends in peroxisome research, and present an update as well as a continuation of two former review articles addressing the unsolved mysteries of this astonishing organelle. We summarize novel findings on the biological functions of peroxisomes, their biogenesis, formation, membrane dynamics and division, as well as on peroxisome–organelle contacts and cooperation. Furthermore, novel peroxisomal proteins and machineries at the peroxisomal membrane are discussed. Finally, we address recent findings on the role of peroxisomes in the brain, in neurological disorders, and in the development of cancer.

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“…In recent years, considerable information has emerged suggesting that dysregulation of peroxisomes is implicated in tumorigenesis ( Dahabieh et al, 2018 ). Enzymes implicated in peroxisomal metabolic processing are dysregulated in numerous neoplasms, including gastric adenocarcinoma ( Jindal et al, 2016 ), cervical cancer ( Wu et al, 2018 ), prostate cancer ( Valenca et al, 2015 ), ovarian cancer ( Sun et al, 2018 ), colorectal neoplasia ( Shukla et al, 2017 ), liver cancer ( Chen et al, 2018 ) and glioblastomas ( Ruokun et al, 2016 ). A recent study reports that silencing PEX2, a peroxin involved in autophagosomal degradation of peroxisomes (pexophagy), reduced tumor growth in liver cancer ( Cai et al, 2018 ).…”

Section: Er and Mitochondria Interactions With Other Organellesmentioning

confidence: 99%

Perspectives on Organelle Interaction, Protein Dysregulation, and Cancer Disease

Díaz

Sandoval-Bórquez

Bravo-Sagua

et al. 2021

Front. Cell Dev. Biol.

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In recent decades, compelling evidence has emerged showing that organelles are not static structures but rather form a highly dynamic cellular network and exchange information through membrane contact sites. Although high-throughput techniques facilitate identification of novel contact sites (e.g., organelle-organelle and organelle-vesicle interactions), little is known about their impact on cellular physiology. Moreover, even less is known about how the dysregulation of these structures impacts on cellular function and therefore, disease. Particularly, cancer cells display altered signaling pathways involving several cell organelles; however, the relevance of interorganelle communication in oncogenesis and/or cancer progression remains largely unknown. This review will focus on organelle contacts relevant to cancer pathogenesis. We will highlight specific proteins and protein families residing in these organelle-interfaces that are known to be involved in cancer-related processes. First, we will review the relevance of endoplasmic reticulum (ER)-mitochondria interactions. This section will focus on mitochondria-associated membranes (MAMs) and particularly the tethering proteins at the ER-mitochondria interphase, as well as their role in cancer disease progression. Subsequently, the role of Ca2+ at the ER-mitochondria interphase in cancer disease progression will be discussed. Members of the Bcl-2 protein family, key regulators of cell death, also modulate Ca2+ transport pathways at the ER-mitochondria interphase. Furthermore, we will review the role of ER-mitochondria communication in the regulation of proteostasis, focusing on the ER stress sensor PERK (PRKR-like ER kinase), which exerts dual roles in cancer. Second, we will review the relevance of ER and mitochondria interactions with other organelles. This section will focus on peroxisome and lysosome organelle interactions and their impact on cancer disease progression. In this context, the peroxisome biogenesis factor (PEX) gene family has been linked to cancer. Moreover, the autophagy-lysosome system is emerging as a driving force in the progression of numerous human cancers. Thus, we will summarize our current understanding of the role of each of these organelles and their communication, highlighting how alterations in organelle interfaces participate in cancer development and progression. A better understanding of specific organelle communication sites and their relevant proteins may help to identify potential pharmacological targets for novel therapies in cancer control.

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Expression of Alpha Methylacyl CoA Racemase (AMACR) in Gastric Adenocarcinoma and Its Correlation with Helicobacter pylori Infection

Cited by 12 publications

References 19 publications

Whole Genome Sequencing Reveals Virulence Potentials of Helicobacter pylori Strain KE21 Isolated from a Kenyan Patient with Gastric Signet Ring Cell Carcinoma

Whole Genome Sequencing Reveals Virulence Potentials of Helicobacter pylori Strain KE21 Isolated from a Kenyan Patient with Gastric Signet Ring Cell Carcinoma

The peroxisome: an update on mysteries 2.0

Perspectives on Organelle Interaction, Protein Dysregulation, and Cancer Disease

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