Plasmatic presepsin (sCD14-ST) concentrations in acute pyelonephritis in adult patients

Claessens, Yann-Érick; Trabattoni, É.; Grabar, Sophie; Quinquis, Laurent; Sahakian, Guillaume Der; Anselmo, Marine; Schmidt, Jeannot; Coussaye, Jean-Emmanuel de La; Plaisance, Patrick; Casalino, Enrique; Potel, G.; Lecomte, François; Borderie, Didier; Chenevier‐Gobeaux, Camille

doi:10.1016/j.cca.2016.11.036

Cited by 17 publications

(13 citation statements)

References 21 publications

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“…Presepsin is one of the biomarkers which increases after bacterial infections [11]. The levels are increased in acute pyelonephritis patients with bacteremia [12] and elevation of presepsin levels before treatment might predict the development of sepsis in patients with obstructive acute pyelonephritis [13].…”

Section: Discussionmentioning

confidence: 99%

Presepsin as a predictor of severe sepsis in urinary tract infection

Sekine¹,

Kotani²,

Oka³

et al. 2021

Preprint

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Background Recently, presepsin is reported to be a biomarker for early diagnosis of sepsis and evaluation of prognosis in septic patients, but there are few reports about urinary-tract infections. The objective of this study is to evaluate whether presepsin is a recent marker for detecting severe sepsis, and whether it can predict the therapeutic course in UTI when compared with procalcitonin (PCT) and C-reactive protein (CRP), already used markers.Methods From April 2014 to December 2016, a total of 50 patients, who were admitted into Gunma university hospital with urinary-tract infections, were enrolled in this study. Vital signs, presepsin, PCT, CRP, white blood cell (WBC), causative diseases of urinary-tract infections and other data were evaluated at the enrollment, third and fifth days. The patients were divided into two groups; with (n=11) or without (n=39) septic shock at the enrollment day, and with (n=7) or without (n=43) sepsis at the fifth day, respectively. Presepsin was evaluated for systemic inflammatory response syndrome (SIRS) or septic shock. Results Concerning the enrollment day, there was no significant difference of presepsin between SIRS and non-SIRS groups (p=0.276). The median presepsin (pg/mL) was significantly higher in the septic shock group (p<0.001). Multivariate logistic regression analysis showed presepsin (≧ 500 pg/ml) was an independent risk factor associated with septic shock (p=0.007). ROC curve for diagnosing septic shock indicated an area under the curve (AUC) at 0.881 for presepsin (vs. 0.690, 0.583 and 0.527 for PCT, CRP and WBC, respectively). Concerning the 5th day after admission, the median presepsin of the enrollment day was significantly higher in SIRS groups than non-SIRS groups (p=0.006). On the other hand, PCT (≥ 2 ng/ml) of the enrollment day was an independent risk factor associated with SIRS. ROC curve for diagnosing sepsis at the fifth day indicated an AUC at 0.837 for PCT (vs. 0.817, 0.811 and 0.802 for presepsin, CRP and WBC, respectively).Conclusions This study shows that presepsin may be a good marker for diagnosis of severe patients who need vasopressor therapy at the data of admission, and PCT may be a good marker for predicting hard-to-treat cases in UTI.

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Section: Discussionmentioning

confidence: 99%

Presepsin as a predictor of severe sepsis in urinary tract infection

Sekine¹,

Kotani²,

Oka³

et al. 2021

Preprint

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“…When there are pathogenic bacteria, the kidneys produce an in ammatory response under the stimulation of pathogenic bacteria and their toxic products. In addition, pathogens and their toxic products may directly enter the circulatory system through the renal parenchyma, thereby causing a systemic in ammatory response and increased production of in ammation indicators [29,30]. It is found that CT images accurately show the degree of kidney infection, and that patients with more severe kidney infections have more severe clinical symptoms [31].…”

Section: Discussionmentioning

confidence: 99%

CT Grading in Upper Urinary Tract Calculi with Kidney Infection

Zhang

Lin

Deng

et al. 2020

Preprint

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Background This study is to establish a CT imaging grading system and to explore its value in evaluating upper urinary tract calculi with kidney infection. Methods CT images of 126 patients with kidney infection caused by upper urinary tract calculi were retrospectively analyzed. CT grading system was developed based on CT images. General information, clinical symptoms and examination data of patients in different CT grades were analyzed. With the occurrence of systemic inflammatory response syndrome (SIRS) as the end point, univariate and multivariate analysis was conducted to analyze the risk factors of SIRS. Results CT images were classified into 4 grades. For patients with different CT grades, the factors of fever, diabetes, blood white blood cell counts, urine leucocytes, CT1 (ratios of renal cortex CT values on the affected side and those on the healthy side), CT2 (ratios of renal pelvis CT values on the affected side and those on the healthy side), maximum body temperature, disease time, proportion of blood neutrophils, C-reactive protein, procalcitonin, and the size of stones had statistical significance (P<0.05). Only CT grading was statistically significant by multivariate analysis. The higher the CT grading, the greater the risk of SIRS, with 4.472 times higher of SIRS risk for each increasement of the CT grade. Conclusions CT images may reflect the involvement extent and scope of upper urinary tract calculi with kidney infection. The higher the CT grade is, the more severe the clinical symptoms are and the greater the risk of SIRS is.

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“…In probable infections with an identifiable focus, presepsin may be of value in differentiating whether an exacerbation of chronic obstructive pulmonary disease is due to pneumonia or non-infectious in etiology [ 14 ], and may also be useful in patients presenting with nephrolithiasis and systemic inflammatory response syndrome (SIRS) symptoms to rule out pyelonephritis as a cause [ 15 ], and may aid in differentiating between the causes of acute abdomen [ 16 ]. In patients with definite pyelonephritis, a higher presepsin cutoff may be used to test for the presence of bacteremia [ 17 ]. A similar effect was found in a study of burn patients, who are at increased risk for severe disseminated infection [ 18 ].…”

Section: Reviewmentioning

confidence: 99%

Presepsin as a Diagnostic and Prognostic Biomarker in Sepsis

Velissaris¹,

Zareifopoulos²,

Karamouzos³

et al. 2021

Cureus

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Sepsis is a condition characterized by high morbidity and mortality which is commonly encountered in an emergency and critical care setting. Despite a substantial body of research, the ideal biomarker for the diagnosis and prognostic stratification of septic patients remains unknown. This review aimed to summarize the publications referring to the validity of the biomarker presepsin when used for the detection, monitoring and prognosis in patients suffering with sepsis. This work is a narrative review based on a PubMed/Medline search conducted in order to identify all relevant publications referring to the use of presepsin in sepsis. Search was not limited by year of publication so all articles archived in the database would be retrieved. No article from before 2010 was identified.A total of 57 publications of the last decade were included, all of which support the use of presepsin as a biomarker for the assessment of septic patients. It has been used alone or in combination with commonly used biomarkers in the evaluation of patients with sepsis in settings such as the emergency department and the intensive care unit. It is useful in the initial workup of patients with suspected sepsis in the emergency setting and may be a predictive factor of mortality and the most severe complication of sepsis.Presepsin seems to be a valuable tool for the laboratory workup of sepsis, especially when used in conjunction with other biomarkers and clinical rating scores with an established role in this population. Further research is needed to evaluate the clinical implications of utilizing presepsin measurements in the workup of sepsis.

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Plasmatic presepsin (sCD14-ST) concentrations in acute pyelonephritis in adult patients

Cited by 17 publications

References 21 publications

Presepsin as a predictor of severe sepsis in urinary tract infection

Presepsin as a predictor of severe sepsis in urinary tract infection

CT Grading in Upper Urinary Tract Calculi with Kidney Infection

Presepsin as a Diagnostic and Prognostic Biomarker in Sepsis

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