Synthesis, Characterization, and Anti-Inflammatory Activities of Methyl Salicylate Derivatives Bearing Piperazine Moiety

Jing-fen, LI; Yin, Yuan‐Qi; Wang, Lisheng; Liang, Pengyun; Li, Menghua; Liu, Xu; Wu, Li; Yang, Hua

doi:10.3390/molecules21111544

Cited by 17 publications

(8 citation statements)

References 24 publications

(23 reference statements)

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“…Moreover p-cymene possess analgesic and anti-cyclodextrin [75]. The potent in vivo anti-inflammatory activities of synthesized methyl salicylate derivatives were demonstrated against xylol-induced ear edema and carrageenan-induced paw edema in mice [76].…”

Section: Biological Properties Of Some Isolated Compounds Of Essential Oils Extracted From Cymbopogon Speciesmentioning

confidence: 96%

Volatile Profiles and Biological Properties of Cymbopogon Citratus, Cymbopogon Giganteus, Cymbopogon Shoenanthus, and Their Isolated Compounds: A Review

Bossou

Bogninou

Dossa

et al. 2020

JBPR

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Essential oils are worldwide used for their several biological properties. As such, the genus Cymbopogon is an interesting source of essential oils. Among the genus Cymbopogon, the most studied plant species, especially in West Africa, are C. citratus, C. giganteus and C. Schoenanthus. The essential oils extracted from these plants are sought for their various properties such as their insecticidal, analgesic, anti-inflammatory, antioxidant, hypotensive properties. Their anti-leishmaniasis, antimicrobial, antiplasmodial anti-acetylcholinesterase, anti-trypanosomal, anti-nociceptive and anticonvulsant potentials were also noted. These different properties are related to the presence of secondary metabolites in these essential oils. It follows that, the Cymbopogon species as well as the volatile compounds contained in their essential oils constitute interesting sources of new bioactive substances likely to fight against several types of resistance phenomena. Thus this literature review constitutes a scientific basis which can contribute to the economic valorization of the genus Cymbopogon. Keywors : Cymbopogon species, volatile profiles, biological properties, cytotoxicity

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Section: Biological Properties Of Some Isolated Compounds Of Essential Oils Extracted From Cymbopogon Speciesmentioning

confidence: 96%

Volatile Profiles and Biological Properties of Cymbopogon Citratus, Cymbopogon Giganteus, Cymbopogon Shoenanthus, and Their Isolated Compounds: A Review

Bossou

Bogninou

Dossa

et al. 2020

JBPR

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“…2-Hydroxybenzoic acid methyl ester (C 8 H 8 O 3 ), commonly known as methyl salicylate, and its derivatives have been shown to display biological effects such as anti-inflammatory, anti-fungal, and process signaling (Yoon et al, 2019;Li et al, 2016;Park et al, 2007). It can also be found in various foods (Duthie & Wood, 2011).…”

Section: Structure Descriptionmentioning

confidence: 99%

Methyl 2-hydroxy-4-iodobenzoate

Kimble,

Myers,

Benedict

2024

IUCr Data

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“…Compound (6) promotes angiogenesis in human umbilical vein endothelial cells. Finally, the newly discovered compound (8) was very similar to salicylic acid in structure, except for the additional methoxy groups, [ 71 ] and had significant analgesic [ 79 ] and anti-inflammatory [ 80 ] effects. With the increasing identification of active compounds, the pharmacological effects of P. americana will be explored further.…”

Section: Characteristics Of P Americanamentioning

confidence: 99%

Periplaneta americana (Insecta: Blattodea) and organ fibrosis: A mini review

et al. 2022

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Fibrosis is the end stage of many chronic inflammatory diseases and eventually leads to organ failure. Periplaneta americana (P. americana) is referred to as “the product of flesh and blood” in traditional Chinese medicine and has a wide range of therapeutic effects. Owing to the growing interest in this insect for its application in the treatment of tissue injury-healing disorders that induce organ fibrosis, it has attracted the interest of researchers. A literature search was performed using core collections of electronic databases, such as PubMed, Web of Science, China National Knowledge Infrastructure, and Wanfang, using the keywords given below and terms such as pharmacological and biochemical details of this insect. P. americana extracts presented a wide range of therapeutic and biological activities, including antifibrotic, antiinflammatory, antioxidative, and tissue repair activities. Emerging evidence suggests that P. americana extracts may improve scarring, pulmonary fibrosis, liver fibrosis, and kidney fibrosis through the regulation of fibroblast activation, cytokine secretion, and deposition of fibrin, indicating the potential role of P. americana as a therapeutic option for organ fibrosis. P. americana is a potential therapeutic agent for treating fibrosis. Further studies are required for a more in-depth characterization of the antifibrogenic mechanism of P. americana prior to its clinical application in the treatment of organ fibrosis. (Fig. 1).

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Synthesis, Characterization, and Anti-Inflammatory Activities of Methyl Salicylate Derivatives Bearing Piperazine Moiety

Cited by 17 publications

References 24 publications

Volatile Profiles and Biological Properties of Cymbopogon Citratus, Cymbopogon Giganteus, Cymbopogon Shoenanthus, and Their Isolated Compounds: A Review

Volatile Profiles and Biological Properties of Cymbopogon Citratus, Cymbopogon Giganteus, Cymbopogon Shoenanthus, and Their Isolated Compounds: A Review

Methyl 2-hydroxy-4-iodobenzoate

Periplaneta americana (Insecta: Blattodea) and organ fibrosis: A mini review

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