Clinical Impact of Mixed Respiratory Viral Infection in Children with Adenoviral Infection

Lee, Hyun Jun; Seo, Yu-Mi; Han, Seung Beom; Jeong, Dae Chul; Kang, Jin Han

doi:10.3947/ic.2016.48.4.309

Cited by 9 publications

(12 citation statements)

References 28 publications

(80 reference statements)

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“…30,31 According to the previous study by Lee et al, multiple respiratory viral infections with HAdV were reported in 30.5% of children. 32 HRV was the most common co-infecting virus which occurring in 69.6% of multiple viral infections. 33 In addition, the most common combinations of multiple viral infections were HRV þ RSV and HRV þ HAdV and triple/quadruple viral infections accounted for a certain proportion similar to the results of previous studies.…”

Section: Discussionmentioning

confidence: 99%

Viral etiologies of acute respiratory tract infections among hospitalized children – A comparison between single and multiple viral infections

Yen¹,

Wu²,

Chang³

et al. 2019

Journal of Microbiology, Immunology and Infection

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Background: Acute respiratory tract infections are commonly caused by viruses in children. The differences in clinical data and outcome between single and multiple viral infections in hospitalized children were analyzed. Methods: We retrospectively reviewed the medical records of hospitalized children who had fever and a xTAG Respiratory Virus Panel (RVP) test over a 2-year period. The clinical data were analyzed and compared between single and multiple viral infections. Viral etiologies in upper and lower respiratory infections were analyzed and compared. Results: A total of 442 patients were enrolled. Patients with positive viral detection (N Z 311) had a significantly lower rate of leukocytosis (p Z 0.03), less evidence of bacterial infection (p Z 0.004), and shorter duration of hospitalization (p Z 0.019) than those with negative viral detection. The age of patients with multiple viral infections was younger than those with single viral infection; however, there were no significant differences in duration of fever, antibiotics treatment and hospitalization between these two groups.The most commonly identified virus was human rhinovirus. About 27% (n Z 83) of patients had multiple viral infections. Overall, the highest percentage of human bocavirus infection was detected in multiple viral infections (79%). Lower respiratory tract infection (LRTI) was Journal of Microbiology, Immunology and Infection (2019) 52, 902e910 independently associated with multiple viral infections (p Z 0.022), respiratory syncytial virus (RSV) infection (p Z 0.001) and longer hospitalization duration (p Z 0.011). Conclusion: Multiple viral infections were associated with younger age and a higher risk of developing LRTI. However, multiple viral infections did not predict a worse disease outcome. More studies are needed to unveil the interplay between the hosts and different viruses in multiple viral infections.

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Section: Discussionmentioning

confidence: 99%

Viral etiologies of acute respiratory tract infections among hospitalized children – A comparison between single and multiple viral infections

Yen¹,

Wu²,

Chang³

et al. 2019

Journal of Microbiology, Immunology and Infection

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“…In another study, an increased risk of life-threatening disease (e.g., intensive care unit [ICU] admission, need for mechanical ventilation, or death) was identified in patients with ADV-RSV coinfections compared to RSV single-virus infections. In a secondary outcome analysis, FLU-RSV coinfections had an increase in LOS compared to RSV single-virus infections (274), while ADV coinfections were more likely to be associated with the need to treat with supplemental oxygen than were ADV single-virus infections (276). Furthermore, in cases of community-acquired pneumonia, viral-bacterial infection has been associated with a more complicated course (e.g., hospital death or mechanical ventilation for Ͼ7 days) than infections with bacteria alone, viruses alone, or no identified etiology (277).…”

Section: Molecular Panel Testing For Respiratory Viruses (I) Defininmentioning

confidence: 96%

Practical Guidance for Clinical Microbiology Laboratories: Viruses Causing Acute Respiratory Tract Infections

et al. 2018

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SUMMARYRespiratory viral infections are associated with a wide range of acute syndromes and infectious disease processes in children and adults worldwide. Many viruses are implicated in these infections, and these viruses are spread largely via respiratory means between humans but also occasionally from animals to humans. This article is an American Society for Microbiology (ASM)-sponsored Practical Guidance for Clinical Microbiology (PGCM) document identifying best practices for diagnosis and characterization of viruses that cause acute respiratory infections and replaces the most recent prior version of the ASM-sponsored Cumitech 21 document,Laboratory Diagnosis of Viral Respiratory Disease, published in 1986. The scope of the original document was quite broad, with an emphasis on clinical diagnosis of a wide variety of infectious agents and laboratory focus on antigen detection and viral culture. The new PGCM document is designed to be used by laboratorians in a wide variety of diagnostic and public health microbiology/virology laboratory settings worldwide. The article provides guidance to a rapidly changing field of diagnostics and outlines the epidemiology and clinical impact of acute respiratory viral infections, including preferred methods of specimen collection and current methods for diagnosis and characterization of viral pathogens causing acute respiratory tract infections. Compared to the case in 1986, molecular techniques are now the preferred diagnostic approaches for the detection of acute respiratory viruses, and they allow for automation, high-throughput workflows, and near-patient testing. These changes require quality assurance programs to prevent laboratory contamination as well as strong preanalytical screening approaches to utilize laboratory resources appropriately. Appropriate guidance from laboratorians to stakeholders will allow for appropriate specimen collection, as well as correct test ordering that will quickly identify highly transmissible emerging pathogens.

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“…Studies have shown that enhanced expression of E1A genes can activate the mitogen-activated protein kinase (MAPK) signalling pathway, allowing HAdv to proliferate continuously in respiratory epithelial cells (26). Persistent latent infection of the lung tissue by E1A genes may lead to airway remodelling (30).…”

Section: Discussionmentioning

confidence: 99%

Epidemiology, Clinical Characteristics, and Prognostic Factors of Atopic Children Hospitalised for Adenovirus Infection: A Single Institutional Study in Shenyang, China

Han

Liu

et al. 2020

Preprint

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Background: Atopy may be associated with the severity of disease and poor prognosis after adenovirus (Adv) infection in children. Our aim was to observe the clinical characteristics and pulmonary radiological changes in atopic children with Adv pneumonia in China.Methods: Children hospitalised for Adv pneumonia from June 2018 to Dec 2019 were analysed. All children were divided into three groups: atopic with Adv, non-atopic with Adv, and atopic without Adv infection. Each group was further divided into mild or severe infection groups according to disease severity. Standard treatment was initiated after admission and regular follow-up evaluations were conducted at 1 month after discharge. Baseline and clinical characteristics, and pulmonary radiological changes of atopic and non-atopic children were collected. Risk factors associated with small airway diseases in Adv pneumonia patients were analyzed.Results: Compared with non-atopic children with Adv infection, the cases of eosinophilic granulocyte count were significantly higher in atopic children than non-atopic children (P<0.05). Among children with mild and severe infection, the number of patients with wheezing and small airway disease as observed by high-resolution computed tomography (HRCT) was significantly higher in atopic children than non-atopic children (P<0.05). Furthermore, coughing was more severe in atopic children than non-atopic children (P<0.05). A family history of asthma (OR 2.1 [95% CI 1.8–3.0]), personal history of asthma (OR 2.7 [95% CI 2.1–3.1]), atopy (OR 2.1 [95% CI 1.8–3.2]), severe infection (OR 1.9 [95% CI 1.0–2.7]), and Adv infection (OR 1.4, [95% CI 0.9–2.0]) were independent factors associated with the development of small airway disease, both after admission and a month after discharge. Conclusions: Atopic children with Adv infection experience more severe coughing during hospitalisation and are prone to wheezing and small airway disease on the HRCT. Family and personal history of asthma, atopy, severe infection, and Adv infection were independent factors associated with the development of small airway disease on the chest HRCT scan.

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Clinical Impact of Mixed Respiratory Viral Infection in Children with Adenoviral Infection

Cited by 9 publications

References 28 publications

Viral etiologies of acute respiratory tract infections among hospitalized children – A comparison between single and multiple viral infections

Viral etiologies of acute respiratory tract infections among hospitalized children – A comparison between single and multiple viral infections

Practical Guidance for Clinical Microbiology Laboratories: Viruses Causing Acute Respiratory Tract Infections

Epidemiology, Clinical Characteristics, and Prognostic Factors of Atopic Children Hospitalised for Adenovirus Infection: A Single Institutional Study in Shenyang, China

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