High prevalence of non-steroidal anti-inflammatory drug use among acute kidney injury survivors in the southern community cohort study

Lipworth, Loren; Abdel-Kader, Khaled; Morse, Jennifer; Stewart, Thomas G.; Kabagambe, Edmond K.; Parr, Sharidan K.; Birdwell, Kelly A.; Matheny, Michael E.; Hung, Adriana M.; Blot, William J.; İkizler, T. Alp; Siew, Edward D.

doi:10.1186/s12882-016-0411-7

Cited by 41 publications

(24 citation statements)

References 43 publications

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“…Furthermore, as most AKI survivors will not see a nephrologist as part of routine follow-up [48], patient education activities focusing on common-sense interventions such as improving medication safety, understanding dietary intake parameters, recognizing signs of volume depletion and overload, and avoiding nephrotoxins are reasonable targets that can be applied by primary caregivers. For example, we recently demonstrated that nearly 20% of patients with a hospitalization that involved a discharge diagnosis of acute renal failure regularly take nonsteroidal anti-inflammatory agents (NSAIDs) following hospital discharge [49]. One recent study examined whether self-reported knowledge of AKI might be modified in patients referred to a specialized post-AKI clinic [50].…”

Section: Discussionmentioning

confidence: 99%

Kidney Disease Awareness and Knowledge among Survivors ofAcute Kidney Injury

et al. 2019

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Background: Acute kidney injury (AKI) survivors are at risk for chronic kidney disease, recurrent AKI, and cardiovascular disease. The transition from hospital to ambulatory care is an opportunity to reduce these sequelae by launching self-care plans through effective patient education. How well AKI survivors are informationally prepared to apply kidney-specific self-care is unknown. The purpose of this study was to identify awareness and disease-specific knowledge among AKI survivors. Methods: We performed a cross-sectional survey of AKI-related awareness and knowledge in 137 patients with Kidney Disease Improving Global Outcomes Stage II or III AKI near the time of hospital discharge. Patients were asked (1) “Did you experience AKI while in the hospital?” and (2) “Do you have a problem with your kidney health?” Objective knowledge of AKI was evaluated with a 15-item adapted version of the validated Kidney Knowledge Survey that included topics such as common causes, risk factors, and how AKI is diagnosed. Results: Median age was 54 (interquartile range 43–63) and 81% were white. Eighty percent of patients were unaware that they had experienced AKI and 53% were both unaware they had experienced AKI or had a “problem with their kidneys.” Multivariable logistic regression identified being male and lack of nephrology consult as predictors of unawareness with ORs of 3.92 (95% CI 1.48–10.33) and 5.10 (95% CI 1.98–13.13), respectively. Less than 50% recognized nonsteroidal anti-inflammatory drugs, contrast, or phosphate-based cathartics as risk factors for AKI. Two-thirds of patients did not agree that they knew a lot about AKI and more than 80% desired more information. Conclusions: Most patients with moderate to severe AKI are unaware of their condition, lack understanding of risk factors for recurrent AKI, and desire more information. Patient-centered communication to optimize awareness, understanding, and care will require coordinated educational strategies throughout the continuum of AKI care.

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Section: Discussionmentioning

confidence: 99%

Kidney Disease Awareness and Knowledge among Survivors ofAcute Kidney Injury

et al. 2019

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“…Ibuprofen in a dosage of 200 mg is OTC drug, however our patients were taking larger doses (400 mg). Larger dose of ibuprofen increases unwanted effects and exposes patient to larger risk from intestineal bleeding, chronic kidney failure etc, and of course increases the possibility of interaction [4,6,[13][14]. Number of unwanted side effects increases with taking more type of drugs and with lenght of taking them [3,6,11].…”

Section: Discussionmentioning

confidence: 99%

Aged Patients and Use of Nonprescription Drugs

Zalihić¹,

Ankica²,

Mirela³

et al. 2016

JLS

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Abstract:Elderly patients over 65, especially those over 75 years are more vulnerable to being prescribed inappropriate medications because of the high incidence of co-medication in this population resulting from the presence of multiple chronic diseases and also age-related changes in pharmacokinetics and pharmacodynamics. The aim at this study was to explore the habits of taking medications without recommendation fracture among older patients, to determine which medications are most often used without prescription, and if there is difference in this habits considering gender and age of respondents. Methods: A cross-sectional study was conducted by interviewing all patients ≥ 65 years that have arrived from 01.10. to 15.12.2015 in one ambulance of the Health Center of Mostar using the adapted questionnaire made out for the research. 90 questionnaires were properly filled for analysis, 60.0% were women and 40.0% of them were men. There was 45.6% respondents between 65 and 75 years, and 54.4% 76 years and above. Resaults: 15.6% of respondents said that they don't take their therapy regularly. Women compared to men, significantly more often use non-prescription drugs (P = 0.007). Analgesics and sedatives are more often used as non-prescription drugs, compare to supplements (P = 0.002). Conclusion: This study, although conducted on a small sample should be an alarm for general practitioners. They should think more about adverse effects of drugs on the aged, and use Beers criteria in every day practice. In addition, pharmacists should respect the legislation and not sell drugs without doctor's prescription to which it applies.

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“…If NSAIDs use is necessary for high-risk patients, it is advisable to use the lowest dose possible for the shortest duration. NSAIDs could precipitate acute kidney injury in patients with compensated heart failure or diabetic nephropathy and also further worsen underlying chronic kidney disease (CKD) [43,44]. The hyperkalemia is mild, but could be critical in patients with elevated K + serum levels due to CKD or with concomitant use of ACE inhibitors.…”

Section: Nonsteroidal Anti-inflammatory Drugs (Nsaids)mentioning

confidence: 99%

Management of Acute Pain in Obese Patients with Sleep Apnea

Rahman¹,

Zaghw²,

Elazzouny³

et al. 2018

Pain Management in Special Circumstances

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Perioperative pain management for obese patients is daily challenges for anesthesiologists especially if complex comorbidities such as Obstructive Sleep Apnea and cardiovascular disease coexist. Limitations to effective pain management in this group are multifactorial, that includes technical difficulty with regional techniques, limited expertise, unavailability of standardized guidelines and lack of familiarity with recent multimodal analgesic regimens. Opioid-related complications such as narcotic-induced ventilatory depression in these group of patients poses another critical concern for both trainees and the experienced anesthesiologists. This chapter is intended for residents, fellows, as well as senior perioperative physicians, and will explore various regional and pharmacological options for acute pain management in this special population based on recent advances and available evidence.

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High prevalence of non-steroidal anti-inflammatory drug use among acute kidney injury survivors in the southern community cohort study

Cited by 41 publications

References 43 publications

Kidney Disease Awareness and Knowledge among Survivors ofAcute Kidney Injury

Kidney Disease Awareness and Knowledge among Survivors ofAcute Kidney Injury

Aged Patients and Use of Nonprescription Drugs

Management of Acute Pain in Obese Patients with Sleep Apnea

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