Clinical characteristics in cholinergic urticaria with palpebral angioedema: Report of 15 cases

Washio, Ken; Fukunaga, Atsushi; Onodera, Minako; Hatakeyama, Mayumi; Taguchi, Kumiko; Ogura, K.; Horikawa, Tsuyoshi; Nishigori, Chikako

doi:10.1016/j.jdermsci.2016.11.001

Cited by 22 publications

(28 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Among them, CholU‐PA is often accompanied by anaphylaxis. Washio et al . reported that seven out of 15 cases of CholU‐PA had anaphylaxis.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Case of cholinergic urticaria accompanied by anaphylaxis

Iijima¹,

Kazumi²,

Takayama³

et al. 2017

The Journal of Dermatology

View full text Add to dashboard Cite

Cholinergic urticaria occasionally occurs in combination with anaphylactic symptoms. However, this has not been widely reported. Herein, we report the case of a 14-year-old Japanese male who was diagnosed with cholinergic urticaria accompanied by anaphylaxis. The patient, who was suffering from atopic dermatitis and bronchial asthma, had developed wheals after exercising or bathing, which would have increased his core body temperature, since summer 2014. He experienced two episodes of severe systemic symptoms and wheal development when he took a bath after eating in December 2014 and the following January. His symptoms included wheezing, numbness of the lips, respiratory distress, blindness and fainting. Laboratory tests revealed the following results: serum IgE level, 7060 IU/mL; titers of specific immunoglobulin E antibodies against Malassezia and MGL_1304, 31.70 UA/mL and 112.5 ng/mL, respectively. A histamine release test against human sweat revealed a class 4 response. Skin prick and intradermal tests against autologous sweat produced immediate-type positive reactions. According to these findings, we diagnosed him with the sweat-hypersensitivity type of cholinergic urticaria accompanied by anaphylaxis. He was successfully treated with lafutidine, a histamine H receptor antagonist, in combination with fexofenadine. It is important for dermatologists to be aware that cholinergic urticaria can progress to anaphylaxis.

show abstract

“…Among them, CholU‐PA is often accompanied by anaphylaxis. Washio et al . reported that seven out of 15 cases of CholU‐PA had anaphylaxis.…”

Section: Discussionmentioning

confidence: 99%

“…Among them, CholU-PA is often accompanied by anaphylaxis. Washio et al 5 reported that seven out of 15 cases of CholU-PA had anaphylaxis. These cases were characterized by female predominance, a positive result in a HRT against sweat and atopic diathesis.…”

Section: Discussionmentioning

confidence: 99%

Case of cholinergic urticaria accompanied by anaphylaxis

Iijima¹,

Kazumi²,

Takayama³

et al. 2017

The Journal of Dermatology

View full text Add to dashboard Cite

show abstract

“…Meanwhile, angioedema is a sudden-onset localized swelling affecting the skin and/or mucosa and occasionally associated with CholU. 2 Here, we report a case of CholU with angioedema, which was successfully treated with omalizumab.…”

Section: Cholinergic Urticaria With Angioedema Successfully Treated Wmentioning

confidence: 94%

Cholinergic urticaria with angioedema successfully treated with omalizumab

Hanai

Aoshima²,

Yagyu

et al. 2019

J Cutaneous Imm & Allergy

View full text Add to dashboard Cite

other one is the depressed sweating type, in which Ach directly acts on mast cells. 6 In the former type, patients develop wheals in response to sweat substance leaking from the syringeal ducts to the dermis. In the latter type, we found that CholU with anhidrosis and hypohidrosis (CUAH) lacks cholinergic receptor M3 expression in eccrine gland epithelial cells. 6 CholU with angioedema is characterized by sweat allergy, female dominancy, concomitant presence of atopic dermatitis, and high frequency of anaphylaxis. 2 Instead of palpebral swelling, lip swelling was prominent in our case.Antihistamines are mostly ineffective in CholU. In several cases, omalizumab has been reported as useful therapy for CholU. 7-9 Our case also documented the effectiveness of omalizumab for both CHolU and the associated symptom of angioedema.

show abstract

“…Some cases of “grain bumps” or stress‐induced urticaria in racing Thoroughbreds could be considered a type of food dependent, exercise‐induced urticaria (Fadok ; Washio et al . ). Avoiding feeding the offending food within 4–5 h of strenuous exercise should prevent the urticaria from developing.…”

mentioning

confidence: 97%

“…Similar to dermatographism, exercise-induced urticarias may be seen when the exercise is combined with other allergens, particularly those associated with foods (Kidd et al 1983;Beaudouin et al 2006). Some cases of "grain bumps" or stress-induced urticaria in racing Thoroughbreds could be considered a type of food dependent, exercise-induced urticaria (Fadok 2014;Washio et al 2017). Avoiding feeding the offending food within 4-5 h of strenuous exercise should prevent the urticaria from developing.…”

mentioning

confidence: 99%

A review of physical urticarias in the horse

Rashmir

2017

Equine Veterinary Education

View full text Add to dashboard Cite

Clinical characteristics in cholinergic urticaria with palpebral angioedema: Report of 15 cases

Cited by 22 publications

References 10 publications

Case of cholinergic urticaria accompanied by anaphylaxis

Case of cholinergic urticaria accompanied by anaphylaxis

Cholinergic urticaria with angioedema successfully treated with omalizumab

A review of physical urticarias in the horse

Contact Info

Product

Resources

About