Inhibition on the growth of human MDA-MB-231 breast cancer cells in vitro and tumor growth in a mouse xenograft model by Se-containing polysaccharides from Pyracantha fortuneana

Yuan, Chengfu; Wang, Changdong; Wang, Junjie; Kumar, Vikas; Anwar, Firoz; Xiao, Fangxiang; Mushtaq, Gohar; Liu, Yuanyuan; Kamal, Mohammad Amjad; Yuan, Ding

doi:10.1016/j.nutres.2016.09.012

Cited by 42 publications

(18 citation statements)

References 42 publications

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“…There are several mechanisms linking obesity and TNBC, including the role of insulin on the AKT/mammalian target of rapamycin (mTOR) signaling network, tissue inflammation, and protumorigenic tissue microenvironment driving the aggressive TNBC (Dietze et al, 2018). Selenium-containing polysaccharide extracted from Pyracantha fortuneana has shown to have anticancer activity against TNBC MDA-MB-231 cells by arresting the cells in the G2 phase and inhibiting CDC25C-CyclinB1/CDC2 pathway (Yuan et al, 2016). This pathway is shown to be hyperactive in obese (ob/ob) mice wherein complex-I is identified as a critical modulator of obesityinduced metabolic remodeling in ß-cells which in turn is regulated by cyclin-dependent kinase-1 (CDK-1) (Gregg et al, 2019).…”

Section: Organoselenium Compounds As Chemopreventive Agents In Obese Breast Cancermentioning

confidence: 99%

Chemopreventive and Anticancer Property of Selenoproteins in Obese Breast Cancer

et al. 2021

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Obesity is a significant risk factor for various cancers including breast cancer resulting in an increased risk of recurrence as well as morbidity and mortality. Extensive studies on various pathways have been successful in establishing a biological relationship between obesity and breast cancer. The molecular classification of breast cancer includes five groups each having different responses to treatment. Increased levels of inflammatory cytokines seen in obese conditions drive the pro-proliferative pathways, such as the influx of macrophages, angiogenesis, and antiapoptotic pathways. Increased peripheral aromatization of androgens by aromatase increases the circulating estrogen levels which are also responsible for the association of obesity with breast cancer. Also, increased oxidative stress due to chronic low-grade inflammation in obese women plays an important role in carcinogenesis. Despite the availability of safe and effective treatment options for breast cancer, obese women are at increased risk of adverse outcomes including treatment-related toxicities. In the recent decade, selenium compounds have gained substantial interest as chemopreventive and anticancer agents. The chemical derivatives of selenium include inorganic and organic compounds that exhibit pro-oxidant properties and alter cellular redox homeostasis. They target more than one metabolic pathway by thiol modifications, induction of reactive oxygen species, and chromatin modifications to exert their chemopreventive and anticancer activities. The primary functional effectors of selenium that play a significant role in human homeostasis are selenoproteins like glutathione peroxidase, thioredoxin reductase, iodothyronine deiodinases, and selenoprotein P. Selenoproteins play a significant role in adipose tissue physiology by modulating preadipocyte proliferation and adipogenic differentiation. They correlate negatively with body mass index resulting in increased oxidative stress that may lead to carcinogenesis in obese individuals. Methylseleninic acid effectively suppresses aromatase activation thus reducing the estrogen levels and acting as a breast cancer chemopreventive agent. Adipose-derived inflammatory mediators influence the selenium metabolites and affect the proliferation and metastatic properties of cancer cells. Recently selenium nanoparticles have shown potent anticancer activity which may lead to a major breakthrough in the management of cancers caused due to multiple pathways. In this review, we discuss the possible role of selenoproteins as chemopreventive and an anticancer agent in obese breast cancer.

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Section: Organoselenium Compounds As Chemopreventive Agents In Obese Breast Cancermentioning

confidence: 99%

Chemopreventive and Anticancer Property of Selenoproteins in Obese Breast Cancer

et al. 2021

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“…In addition, the native polysaccharides isolated from the roots of Hedysarum polybotrys also showed an immunomodulatory effect [261]. However, the research demonstrated that the H. polybotrys polysaccharides modified with selenium had a stronger antioxidant effect, reflected by the removal of superoxide and hydroxyl radicals [390]. In another study with a group of rats administered CCl 4 , the biological activity of Se-polysaccharides isolated from the root of Astragalus membranoceus was compared with those of the natural polysaccharides.…”

Section: Plant Se-polysaccharidesmentioning

confidence: 99%

Selenium-Containing Polysaccharides—Structural Diversity, Biosynthesis, Chemical Modifications and Biological Activity

2021

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Selenosugars are a group of sugar derivatives of great structural diversity (e.g., molar masses, selenium oxidation state, and selenium binding), obtained as a result of biosynthesis, chemical modification of natural compounds, or chemical synthesis. Seleno-monosaccharides and disaccharides are known to be non-toxic products of the natural metabolism of selenium compounds in mammals. In the case of the selenium-containing polysaccharides of natural origin, their formation is also postulated as a form of detoxification of excess selenium in microorganisms, mushroom, and plants. The valency of selenium in selenium-containing polysaccharides can be: 0 (encapsulated nano-selenium), IV (selenites of polysaccharides), or II (selenoglycosides or selenium built into the sugar ring to replace oxygen). The great interest in Se-polysaccharides results from the expected synergy between selenium and polysaccharides. Several plant- and mushroom-derived polysaccharides are potent macromolecules with antitumor, immunomodulatory, antioxidant, and other biological properties. Selenium, a trace element of fundamental importance to human health, has been shown to possess several analogous functions. The mechanism by which selenium exerts anticancer and immunomodulatory activity differs from that of polysaccharide fractions, but a similar pharmacological effect suggests a possible synergy of these two agents. Various functions of Se-polysaccharides have been explored, including antitumor, immune-enhancement, antioxidant, antidiabetic, anti-inflammatory, hepatoprotective, and neuroprotective activities. Due to being non-toxic or much less toxic than inorganic selenium compounds, Se-polysaccharides are potential dietary supplements that could be used, e.g., in chemoprevention.

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“…More interestingly, Se-PFPs was reported as containing carbohydrates [93.7% (w/w)], uronic acid [2.1% (w/w)] and selenium [3.7 μg/g]. (54). Similarly, Sun, Dong (55) reported that Se-PFPs reduced cyclin D1, Bcl-2 and matrix metallopeptidase 9 (MMP-9), Ncadherin, vimentin, ZEB1 and ZEB2 and increased the cleavage of PARP, caspase-3, and -9, E-cadherin and cytokeratin 19 in HEY and SKOV3 human ovarian cancer cells.…”

Section: Pyracantha Fortuneana (Maxim) H L Limentioning

confidence: 99%

Biological activities and health-promoting effects of Pyracantha genus: a key approach to the phytochemical's potential

Sharifi‐Rad

Taheri

Ayatollahi

et al. 2020

Cell Mol Biol (Noisy-le-grand)

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Pyracantha spp. are commonly called firethorn, and attract human attention due to their colorful berries. These berries are eaten globally as a traditional remedy for treating different stomach abnormalities, and as a cooking ingredient for folk diets. The present review aims to provide an overview on Pyracantha genus' geographical distribution and botanical description, traditional uses, phytochemical composition, biological activities and safety issues. Several biological activities have been reported to Pyracantha species, namely antioxidant, anti-inflammatory, antimicrobial, larvicidal and cytotoxic properties, most of them attributed to the use of their fruits. Pyracantha species phytochemical composition reveal the presence of interesting bioactive molecules, such as pyracrenic acid and fortuneanosides. The currently reported biological activities to these plants derive from in vitro and in vivo studies, so that clinical trials are needed to confirm these preclinical results. Nonetheless, Pyracantha species can be suggested as a safe herb useful to develop future drug formulations and functional foods.

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Inhibition on the growth of human MDA-MB-231 breast cancer cells in vitro and tumor growth in a mouse xenograft model by Se-containing polysaccharides from Pyracantha fortuneana

Cited by 42 publications

References 42 publications

Chemopreventive and Anticancer Property of Selenoproteins in Obese Breast Cancer

Chemopreventive and Anticancer Property of Selenoproteins in Obese Breast Cancer

Selenium-Containing Polysaccharides—Structural Diversity, Biosynthesis, Chemical Modifications and Biological Activity

Biological activities and health-promoting effects of Pyracantha genus: a key approach to the phytochemical's potential

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