Effect of near-infrared light on in vitro cellular ATP production of osteoblasts and fibroblasts and on fracture healing with intramedullary fixation

Abstract

The study demonstrated an immediate increase in ATP production and an initial acceleration of callus formation in the fracture healing process, in the presence of NIR.

Conservative Management and Serial Magnetic Resonance Imaging in an Athlete with Radiographically Unstable Juvenile Osteochondritis Dissecans of the Knee: Case Report

“…Near-infrared light therapy was used to accelerate the healing of the left knee JOCD using a laser in the clinic and bulb for home use. Near-infrared light may accelerate the healing of bone injuries by stimulating osteoblasts [22]. Evidence is limited to animal studies, such as one animal study that found laser therapy improved signs of healing of osteochondral defects [23].…”

Strontium Ranelate Combined with Insulin Is as Beneficial as Insulin Alone in Treatment of Fracture Healing in Ovariectomized Diabetic Rats

“…At 2 or 3 weeks after fracture, the rats were anesthetized using sodium pentobarbital (40 mg/kg), radiographs were obtained in the anteroposterior orientation by high-resolution digital radiography using a DR 7500 system (Eastman Kodak Co., Rochester, United States) at an exposure of 45 kV for 5.5 s, and the femora were harvested. A radiographic healing score as described previously was assessed independently by 3 observers to grade the fracture healing [ 23 ]. The fracture healing was graded as follows: Grade 1, no calcification; Grade 2, patchy-calcification; Grade 3, calcification has the appearance of a callus; Grade 4, callus bridging across the fracture gap; Grade 5, continuity of bone trabeculae; Grade 6, remodeling to normal bone.…”

Mitochondrial Dysfunction and Parkinson’s Disease—Near-Infrared Photobiomodulation as a Potential Therapeutic Strategy

“…NIR-mediated reduction in IWL viscosity decreases the friction opposing ATP synthase rotation and results in ''smoother'' turning of the ATP synthase machinery. This theory is supported by the fact that cellular ATP level increases are immediate after PBM stimulation (Quirk et al, 2016), suggesting that the intracellular changes mediating elevated ATP production are alterations in physical properties rather than chemical processes, as the latter tends to occur with a slight time lag (Sommer, 2019). Yet another group suggested that the photo-absorbent metabolite pyropheophorbide-a (P-a) of dietary chlorophyl could facilitate light-driven energy production processes in animals (Xu et al, 2014).…”