99mTc-labeled White Blood Cell Scan as a Guide to Open Biopsy in the Management of Hip and Knee Prosthesis Infection: Preliminary Results

Liberatore, Mauro; Gentile, Giuseppe; Follacchio, Giulia Anna; Frantellizzi, Viviana; Vincentis, Giuseppe De; Monteleone, Francesco; Anagnostou, Christos; Drudi, Francesco Maria; Calvisi, Vittorio

doi:10.2174/1874471009666161117120358

Cited by 8 publications

(4 citation statements)

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“…Advanced detection methods such as X-ray computed tomography (99mTc-WBC SPECT/CT) and white blood cell scanning, which can analyze the prognosis of diabetic foot infection, are not available in China. 29,30 Therefore, the STAGE principles cannot be used to objectively determine the depth of the target anatomical layer for incision. The assessment of the incision depth still depends on clinical experience.…”

Section: Discussionmentioning

confidence: 99%

Principles of STAGE Management for Diabetic Foot Ulcers Based on the Wagner and Texas Classification Systems

Zhu

Zhou²,

Lü

et al. 2019

The International Journal of Lower Extremity Wounds

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The current Wagner and Texas classifications of diabetic foot ulcers (DFUs) are used worldwide to assess the extent of foot lesions, but wound treatment principles based on both the classification systems are lacking. We have summarized the STAGE principles of wound treatment for clinical practice based on the Wagner and Texas classification systems. The STAGE principles refer to the principles of surgical intervention during wound treatment of DFUs and emphasize that “based on anatomical layers, the management focuses on blood supply and includes layer-by-layer incision to the infected area, maintenance of effective wound drainage, and step-by-step treatment of the wound.” During treatment, microcirculation improvement and microvascular angiogenesis (A) are essential for granulation tissue formation in the bone (skeleton, S) and tendons (T) and healing of the wound with reepithelialization (E). We defined the above mentioned steps as the STAGE principles, namely, layer-by-layer incision and step-by-step management (Phase A is essential for the treatments in Phases S-T and G-E). Ulcers or gangrene formed during Phases S-T or T should be treated according to the STAGE or TAGE principles, respectively. Similar treatment principles are applied in the other phases. However, treatments at each phase are not isolated and can be performed simultaneously. The STAGE principle can be combined with the tissue, infection, moisture, and wound edge (TIME) and TIME-H chronic wound treatment principles to eliminate the shortcomings of a single principle in wound management.

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Section: Discussionmentioning

confidence: 99%

Principles of STAGE Management for Diabetic Foot Ulcers Based on the Wagner and Texas Classification Systems

Zhu

Zhou²,

Lü

et al. 2019

The International Journal of Lower Extremity Wounds

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“…In its starting era, it used different radioisotopes clinically to catch the glimpse of DSI; however, after the discovery of 99m Tc radionuclide having patient friendly characteristics (short half‐life 6 hr, isomeric transition (gamma) decay process, and adequate gamma photon energy 140 Kev), variety of biological and synthetic molecules were labeled with 99m Tc for infection and tumor imaging. Initially, the 99m Tc‐WBC and 67 Ga ‐citrate radiopharmaceutical were clinically used for infection imaging with low to high sensitivity (Liberatore et al, 2017; Palestro et al, 2013). However, due to multiple demerits associated with 99m Tc‐WBC and 67 Ga ‐citrate, new infection imaging radiotracers were studied.…”

Section: Mtc‐labeled Antibiotics and Their Efficacymentioning

confidence: 99%

^99mTc‐labeled antibiotics for infection diagnosis: Mechanism, action, and progress

Naqvi

2021

Chem Biol Drug Des

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Discovery of penicillin marked a turning point in the history of infection therapy which also led to the emergence of bacterial resistance. It is now 100 years to fight with ever‐muted variants of pathogens by developing more and more antibiotics. Since 1987 to todate, no successful class of antibiotic was introduced; this three decade period is known as “the discovery void” period. While, the clinically approved antibiotics are gradually dying in front of bacterial resistance due to which bacterial infections are appearing leading cause of death and disability. Nuclear medicine imaging technique is the strongest modality to diagnose and follow‐up of deep‐seated and complicated infections. However, the selection of radiolabeled antimicrobial agents plays critical role in gaining sensitivity and specificity of the imaging results. This review comprises of two main sections; first section explains antibiotic targets, and second section explains the imaging efficacy of 99mTc‐labeled antimicrobial agents against bacterial infection along with the emphasis on progress and update of 99mTc‐labeled antibiotics as infection imaging probes. The review, in conclusion, could be an acceleration for radiopharmaceutical chemists for designing and developing 99mTc‐labeled antimicrobial agents to improve infection imaging quality.

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“…Similar to previous studies, SPECT/CT allowed more accurate localization of abnormal uptake on bone and white cell scintigraphy. Recently, preliminary results of a study by Liberatore et al [29] showed potential of white blood cell scan as a guide to open biopsy in the management of hip and knee prosthesis infection.…”

Section: Data Extractionmentioning

confidence: 99%

General Assembly, Diagnosis, Imaging: Proceedings of International Consensus on Orthopedic Infections

Díaz-Ledezma¹,

Espinosa-Mendoza²,

Gallo³

et al. 2019

The Journal of Arthroplasty

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99mTc-labeled White Blood Cell Scan as a Guide to Open Biopsy in the Management of Hip and Knee Prosthesis Infection: Preliminary Results

Abstract: The obtained results indicate that a multidisciplinary approach to infection of orthopedic prostheses, characterized by the combined use of open biopsy, WBC, and microbiological examination, produced positive outcome in 9 out of 14 patients.

Cited by 8 publications

References 0 publications

Principles of STAGE Management for Diabetic Foot Ulcers Based on the Wagner and Texas Classification Systems

Principles of STAGE Management for Diabetic Foot Ulcers Based on the Wagner and Texas Classification Systems

^99mTc‐labeled antibiotics for infection diagnosis: Mechanism, action, and progress

General Assembly, Diagnosis, Imaging: Proceedings of International Consensus on Orthopedic Infections

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