Novel Function of Isoamylamine Improves Survival in Endotoxemic Mice by Ameliorating Coagulopathy and Attenuating MMP-9 Expression Through p-ERK/p-p38 Signaling at Early Stage
Abstract:When a host suffers endotoxemic shock or septic shock, it results in many symptoms including disseminated intravascular coagulation (DIC). Septic shock (SS) causes coagulation time to decrease and then gradually increase, finally becoming prolonged and giving rise to DIC. Isoamylamine (IA) is one of the main components of grape products and can improve the survival rate of endotoxin lipopolysaccharide (LPS)-induced endotoxemic shock. The aim of this study was to elucidate if IA ameliorates coagulopathy in the … Show more
“…More recently, cardiac levels of isoamylamine were reported to negatively correlate with septal wall thickness and to be increased in patients suffering cardiac arrest (Meana et al, 2016). Isoamylamine was also suggested to be beneficial in an animal model of endotoxemia (Yen et al, 2016). The mechanism and importance of these putative effects requires further study.…”
“…More recently, cardiac levels of isoamylamine were reported to negatively correlate with septal wall thickness and to be increased in patients suffering cardiac arrest (Meana et al, 2016). Isoamylamine was also suggested to be beneficial in an animal model of endotoxemia (Yen et al, 2016). The mechanism and importance of these putative effects requires further study.…”
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