Biomonitoring of 21 endocrine disrupting chemicals in human hair samples using ultra-high performance liquid chromatography–tandem mass spectrometry

Rodríguez-Gómez, R.; Martín, Julia; Zafra-Gómez, A.; Alonso, Esteban; Vı́lchez, J.L.

doi:10.1016/j.chemosphere.2016.11.008

Cited by 40 publications

(10 citation statements)

References 43 publications

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Section: Figurementioning

confidence: 99%

“…Xenoestrogens are absorbed into the human body via digestion, inhalation and transdermal absorption. Compounds were detected in human hairs, breast milk, blood, adipose tissue, cord blood, amniotic fluid, urine, menstrual blood, and semen [13][14][15][16][17][18][19]. In this review, we have attempted to answer the question: how do XEs modulate the expression of the NF-κB pathway in immune cells?…”

Section: Introductionmentioning

confidence: 99%

“…Due to the latest trends promoting an ecological and healthy lifestyle, researchers show an increasing interest in the exposure of humans to chemical substances, which are found in food, drugs, cosmetics, plastics, and detergents ( Table 1 ) [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ]. Some ingredients of these products are substances that mimic the action of endogenous estrogens and are collectively known as xenoestrogens (XEs) ( Figure 1 ) [ 13 , 14 , 15 , 16 , 17 , 18 , 19 ]. These substances affect the organisms mainly by interacting with their nuclear hormone receptors and modulating the intracellular signaling pathways.…”

Section: Introductionmentioning

confidence: 99%

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NF-κB—An Important Player in Xenoestrogen Signaling in Immune Cells

Nowak

Jabłońska

Ratajczak–Wrona

2021

Cells

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The proper functioning of the immune system is critical for an effective defense against pathogenic factors such as bacteria and viruses. All the cellular processes taking place in an organism are strictly regulated by an intracellular network of signaling pathways. In the case of immune cells, the NF-κB pathway is considered the key signaling pathway as it regulates the expression of more than 200 genes. The transcription factor NF-κB is sensitive to exogenous factors, such as xenoestrogens (XEs), which are compounds mimicking the action of endogenous estrogens and are widely distributed in the environment. Moreover, XE-induced modulation of signaling pathways may be crucial for the proper development of the immune system. In this review, we summarize the effects of XEs on the NF-κB signaling pathway. Based on our analysis, we constructed a model of XE-induced signaling in immune cells and found that in most cases XEs activate NF-κB. Our analysis indicated that the indirect impact of XEs on NF-κB in immune cells is related to the modulation of estrogen signaling and other pathways such as MAPK and JAK/STAT. We also summarize the role of these aspects of signaling in the development and further functioning of the immune system in this paper.

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Section: Figurementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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NF-κB—An Important Player in Xenoestrogen Signaling in Immune Cells

Nowak

Jabłońska

Ratajczak–Wrona

2021

Cells

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“…These chemicals are metabolized and conjugated in the liver and excreted, with half-lives measured in hours [ 122 ]. Given their widespread uses, and potential for contamination by parent chemicals, analysis of conjugated urinary metabolites is preferred, although concentrations have been reported in serum and plasma [ 122 , 123 ], and more recently in hair [ 124 ]. Several chemicals in this class have been the target of policy and regulatory activities which can result in changing exposure profiles.…”

Section: Opportunities For Research and Future Biomonitoring In Echomentioning

confidence: 99%

Opportunities for evaluating chemical exposures and child health in the United States: the Environmental influences on Child Health Outcomes (ECHO) Program

Buckley

Barrett

Beamer

et al. 2020

J Expo Sci Environ Epidemiol

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The Environmental Influences on Child Health Outcomes (ECHO) Program will evaluate environmental factors affecting children’s health (perinatal, neurodevelopmental, obesity, respiratory, and positive health outcomes) by pooling cohorts composed of >50,000 children in the largest US study of its kind. Our objective was to identify opportunities for studying chemicals and child health using existing or future ECHO chemical exposure data. We described chemical-related information collected by ECHO cohorts and reviewed ECHO-relevant literature on exposure routes, sources, and environmental and human monitoring. Fifty-six ECHO cohorts have existing or planned chemical biomonitoring data for mothers or children. Environmental phenols/parabens, phthalates, metals/metalloids, and tobacco biomarkers are each being measured by ≥15 cohorts, predominantly during pregnancy and childhood, indicating ample opportunities to study child health outcomes. Cohorts are collecting questionnaire data on multiple exposure sources and conducting environmental monitoring including air, dust, and water sample collection that could be used for exposure assessment studies. To supplement existing chemical data, we recommend biomonitoring of emerging chemicals, non-targeted analysis to identify novel chemicals, and expanded measurement of chemicals in alternative biological matrices and dust samples. ECHO’s rich data and samples represent an unprecedented opportunity to accelerate environmental chemical research to improve the health of US children.

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“…Endocrine-disrupting chemicals (EDCs) are a group of emerging contaminants that are potentially hazardous towards living organisms even at trace concentrations (Gmurek et al 2017;Rodríguez-Gómez et al 2017). Due to their widespread use in chemical and agricultural industries, EDCs are ubiquitous in the aquatic environment (Solé and Matamoros 2016).…”

Section: Introductionmentioning

confidence: 99%

High salinity enhances the adsorption of 17α-ethinyl estradiol by polyethersulfone membrane: isotherm modelling and molecular simulation

Goh

Yip

et al. 2021

Int. J. Environ. Sci. Technol.

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The increasing occurrence of steroidal hormone micropollutant in the aquatic environment and their associated consequences have caused serious environmental concerns globally. Adsorptive removal of hormonal pollutants using polymeric membranes has been suggested but information on their performance in various environmental conditions is lacking. In this study, we examined the effect of salinity on the performance of polyethersulfone (PES) membrane to remove synthetic hormone 17α-ethinyl estradiol (EE2) from water. Our results show that an increase of salinity from 0 to 3% results in higher retention of EE2 onto PES membrane from 79.3 to 98.7%. The experimental results fit the Freundlich isotherm model better as compared to the Langmuir model. The Freundlich parameters n and Kf yielded the highest values at 3% salinity. The molecular simulation results suggest that a high salinity increases the binding energy between EE2 and PES membranes, promoting the PES-EE2 interaction through π–π interaction, hydrogen bonding and hydrophobic interaction. This study provides valuable information for improving design of specialised treatment facilities (in farming, pharmaceutical industries, etc.) to allow better removal of EE2 and other low-polar organic contaminants from water via a membrane-based sorption-elution method, and we recommend the inclusion of salinity as a factor in modelling the adsorption capacity of membranes to prevent the oversaturation of membrane and minimise the release of contaminants into the environment.

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Biomonitoring of 21 endocrine disrupting chemicals in human hair samples using ultra-high performance liquid chromatography–tandem mass spectrometry

Cited by 40 publications

References 43 publications

NF-κB—An Important Player in Xenoestrogen Signaling in Immune Cells

NF-κB—An Important Player in Xenoestrogen Signaling in Immune Cells

Opportunities for evaluating chemical exposures and child health in the United States: the Environmental influences on Child Health Outcomes (ECHO) Program

High salinity enhances the adsorption of 17α-ethinyl estradiol by polyethersulfone membrane: isotherm modelling and molecular simulation

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