Sibutramine provokes apoptosis of aortic endothelial cells through altered production of reactive oxygen and nitrogen species

Impact of timing of the anorexigen sibutramine administration on reproductive end‐points of male rats

“…[11][12][13][14]18,28 Despite its effectiveness in losing weight, several side effects have been reported, including cardiac arrhythmia, myocardial infarction, cardiomyopathy and high blood pressure. 10,29 Previous studies conducted in our laboratory reported lower sperm quality and fertility in rats exposed for 30 days to sibutramine during the light phase of the l/d cycle. 2,3 In the present study, we aimed to investigate whether a change in the timing of drug administration, that is during the dark phase of l/d cycle, when rodents have higher metabolic activity and increased availability of norepinephrine, 22 would change these deleterious effects on reproduction.…”

“…Sibutramine, a monoamine reuptake inhibitor, is the drug of choice for obesity treatment in countries where this drug is still legal and also can be found in composition of teas and supplements to lose weight in those countries where its commercialization is illegal 11‐14,18,28 . Despite its effectiveness in losing weight, several side effects have been reported, including cardiac arrhythmia, myocardial infarction, cardiomyopathy and high blood pressure 10,29 . Previous studies conducted in our laboratory reported lower sperm quality and fertility in rats exposed for 30 days to sibutramine during the light phase of the l/d cycle 2,3 .…”

“…[4][5][6] The efficacy of this drug in losing weight is well known; however, the literature has reported many side effects, particularly high blood pressure, which has resulted in the prohibition of this drug in several countries. [7][8][9][10] Currently, in these countries, there are reports of the use of sibutramine in mixed teas, known that rodents are nightlife animals, with higher metabolic activity during the dark phase than in the light phase of the light-dark (l/d) cycle. Thus, the present study aimed to investigate whether the deleterious effects on reproductive parameters after sibutramine administration would be enhanced after a shorter period of exposure during the dark phase of the l/d cycle.…”

“…Sibutramine is a non‐selective norepinephrine reuptake inhibitor administered orally for weight loss 4‐6 . The efficacy of this drug in losing weight is well known; however, the literature has reported many side effects, particularly high blood pressure, which has resulted in the prohibition of this drug in several countries 7‐10 . Currently, in these countries, there are reports of the use of sibutramine in mixed teas, natural compounds and slimming supplements to accelerate the weight loss 11‐14 .…”

Highly resistant and sensitive colorimetric immunochromatographic assay for sibutramine (SBT) illegally adulterated into diet food based on PDA/AuNP labelling

“…However, SBT causes severe detrimental side effects, including nervousness, xerostomia, vasoconstriction, and increased cardiovascular events, such as stroke and heart attack in patients. 2 Since 2010, the U.S Food and Drug Administration, the European Commission, and the Ministry of Health of the People's Republic of China have banned the use of SBT as a medicine for weight control. 3 Despite this, illicit weight loss food or herbal products containing SBT 4 are still occasionally available in the market, especially via e-commerce.…”