Evaluation of acute skin toxicity in breast radiotherapy with a new quantitative approach

Fundamental supply of skin blood flow in the Chinese Han population: Measurements by a full‐field laser perfusion imager

“…13,14 Previously study had approved microcirculation of skin is related to systemic disease, such as systemic sclerosis, 15 Kawasaki disease, 16 polycystic ovary syndrome, 17 burn scar, Bell's palsy, and acute radio dermatitis. [18][19][20] Our study confirmed that blood flow in different cutaneous regions varied. 6,17,21,22 Face and fingertips have higher perfusion values, especially eyelid and lips, which is consistent to the conclusion of Tur.…”

“…Skin covers the body and is known as the largest organ in the human and the most important role is its barrier functions . Previously study had approved microcirculation of skin is related to systemic disease, such as systemic sclerosis, Kawasaki disease, polycystic ovary syndrome, burn scar, Bell's palsy, and acute radio dermatitis …”

Oral curcumin for radiation dermatitis: a URCC NCORP study of 686 breast cancer patients

“…Gonzalez Sanchis et al showed that real-time laser Doppler flowmetry (LDF), which measure cutaneous microcirculation, is an accurate, objective measure for radiation dermatitis severity [15]. The microcirculation index significantly increased from baseline to end of RT and the skin changes were classified more objectively using LDF compared to CTC scale [15]. Additionally, Esteva et al demonstrated the importance of capturing skin reactions by digital photography [10].…”

High‐frequency ultrasound quantification of acute radiation dermatitis: pilot study of patients undergoing radiotherapy for breast cancer

“…Clinical assessment is based on visual clinical grading scales (CTCAE, RTOG, WHO). Some other approaches have involved skin color or skin blood flow used to quantify acute radiation dermatitis . However, these techniques are not widely available, and measurements may be altered by temperature and skin vasoconstriction.…”