Clinical Features of Smokers With Radiological Emphysema But Without Airway Limitation

Alcaide, Ana B.; Sánchez-Salcedo, Pablo; Bastarrika, Gorka; Campo, Arantza; Bertó, Juan; Ocón, María del Mar; Fernández-Montero, Alejandro; Celli, Bartolomé R.; Zulueta, Javier; de-Torres, Juan P.

doi:10.1016/j.chest.2016.10.044

Cited by 34 publications

(38 citation statements)

References 35 publications

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“…The DL CO may not necessarily reflect early emphysema, since it may be due to other smoking‐related changes, including altered membrane diffusion, pulmonary vascular changes and increased carboxyhaemoglobin which were not measured in this cohort . In smokers with normal spirometry but emphysema on CT, DL CO was reduced in only about half of smokers . Although respiratory impedance measured by FOT in COPD related to CT‐measured emphysema, this may not necessarily apply to non‐COPD smokers.…”

Section: Discussionmentioning

confidence: 85%

Peripheral airway dysfunction and relationship with symptoms in smokers with preserved spirometry

et al. 2017

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Section: Discussionmentioning

confidence: 85%

Peripheral airway dysfunction and relationship with symptoms in smokers with preserved spirometry

et al. 2017

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“…In some of these patients, computed tomography (CT) of the thorax has demonstrated pulmonary emphysema; although these individuals do not fulfill the diagnostic criteria of COPD proposed by GOLD, they have a pulmonary disease associated with smoking or with another exposure (Fig. 1) 10 . Due to the possible progression to airflow limitation, this disorder was named "pre-COPD 6 ," which was recognized by GOLD since 2006 as Stage 0.…”

Section: Definitionmentioning

confidence: 99%

Controversies and Limitations in the Diagnosis of Chronic Obstructive Pulmonary Disease

Reyes-García

Torre-Bouscoulet

Pérez‐Padilla

2019

RIC

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Chronic obstructive pulmonary disease (COPD) is a major cause of chronic morbidity and mortality worldwide. While the cutoff point to define airflow obstruction has been controversial, it is widely accepted that the spirometry test is vital, as well as performing it after using a bronchodilator. The 6-second spirometry and the forced expiratory volume in 1 second/forced expiratory volume in 6 seconds (FEV 1 /FEV 6) have demonstrated validity for defining obstruction, and it would be advisable to incorporate them in the definitions of obstruction. Another relevant issue is that spirometry with borderline obstruction can vary over time, changing to above or below the cutoff point. Thus, surveillance should be considered over time, repeating the spirometry to have a greater certainty in the diagnosis. The objective of this article was to conduct an in-depth review of the controversies in the diagnosis of COPD. During the past years, COPD definition has been updated in different times; however, it is now considered more as a complex syndrome with systemic participation, requiring a multidimensional assessment, and not only a spirometry.

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“…However, it is still unclear whether emphysema predisposes patients with COPD to such systemic manifestations and whether systemic manifestations contribute to the development of emphysema 62 , nor if patients with initial presentation as symptomatic emphysema without airway limitation then progress to spirometric COPD 63 .…”

Section: Barcelona Respiratory Networkmentioning

confidence: 99%

The Impact of Emphysema on Chronic Obstructive Pulmonary Diseases

Torres¹,

Casanova²

2017

BRN

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Emphysema is defined as an abnormal and permanent enlargement of the air spaces distal to the terminal bronchioles that is accompanied by destruction of the air space walls, with no obvious fibrosis (i.e. there is no fibrosis visible to the naked eye) and it is usually associated to tobacco smoking. Although it is included in the pathological definition of chronic obstructive pulmonary disease (COPD), not all COPD patients have emphysema and its impact on the clinical presentation and the natural history of the disease is variable. The present review will cover the prevalence of emphysema in COPD patients, its impact on the clinical presentation, association with comorbidities and the main outcomes of the disease: exacerbations, lung function decline and mortality. In this review, we will only evaluate the relationship of tobacco-related emphysema with COPD. (BRN Rev. 2017;3:235-46)

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Clinical Features of Smokers With Radiological Emphysema But Without Airway Limitation

Cited by 34 publications

References 35 publications

Peripheral airway dysfunction and relationship with symptoms in smokers with preserved spirometry

Peripheral airway dysfunction and relationship with symptoms in smokers with preserved spirometry

Controversies and Limitations in the Diagnosis of Chronic Obstructive Pulmonary Disease

The Impact of Emphysema on Chronic Obstructive Pulmonary Diseases

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