A review of human biomonitoring data used in regulatory risk assessment under Canada's Chemicals Management Program

Zidek, Angelika; Macey, Kristin; MacKinnon, Leona; Patel, Mikin; Poddalgoda, Devika; Zhang, Yi

doi:10.1016/j.ijheh.2016.10.007

Cited by 34 publications

(8 citation statements)

References 35 publications

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“…The plan provides the basis to formulate national public policies and includes investments to advance research and environmental monitoring, including pharmaceuticals and personal care products. Since then, assessments have included over 4,300 chemical priorities under the CMP; more than 2,700 substances have been assessed, and over 130 were concluded to be toxic 56 .…”

Section: • Monitoring Pharmaceutical Programs In Water Bodiesmentioning

confidence: 99%

Pharmaceutical market, environmental public policies and water quality: the case of the São Paulo Metropolitan Region, Brazil

et al. 2020

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Water pollution has been an increasing concern for the authorities responsible for planning and executing public policies. In this qualitative research, we have discussed the most sold pharmaceuticals in the São Paulo Metropolitan Region, Brazil, and compared public policies focused on pharmaceuticals and environmental issues among countries/regions. For that, data provided by Close-Up International related to the sales of medicines in the São Paulo Metropolitan Region between April/2016 and April/2017 were collected and processed to identify and quantify the pharmaceutical products. The 300 most sold medicines in the São Paulo Metropolitan Region fall in 26 therapeutic classes, which include 159 drugs. The most sold pharmaceutical products group is nonsteroidal anti-inflammatory drugs (NSAIDs) representing approximately 44.3% of the total. The ten most sold pharmaceuticals sum up 1200 tons. Dipyrone is the first place in mass representing around 488 tons, followed by metformin with around 310 tons commercialized. Public policies focused on pharmaceuticals in the environment still need adjustments to improve reinforcement, even in developed countries. There is no international standard on how to conduct the issue, each country adopting the public policy that best matches to the local. Brazil, despite having some legislation that approaches the theme, still lacks effective public policies and stakeholder awareness. In this aspect, the need for improvement of the reverse logistics system, consumer orientation to the adequate disposal of unused/expired medicines, and the adoption of the unit-dose system as a therapeutic strategy is evident.

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Section: • Monitoring Pharmaceutical Programs In Water Bodiesmentioning

confidence: 99%

Pharmaceutical market, environmental public policies and water quality: the case of the São Paulo Metropolitan Region, Brazil

et al. 2020

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“…By reviewing published Water Environment Research, Volume 90, Number 10 -Copyright © 2018 Water Environment Federation studies, this review found that systematic review as well as meta regression analysis could be considered as an ideal method towards addressing chemical risk assessment due to its advantages to bring the answer for the endpoint question of a chemical risk assessment. Zidek et al (2017) noted that few case studies have been presented on the use of inorganic and organic substances in order to show the impact and overall role on human biomonitoring. In Canada, there is a regulatory decision making process using 3 substances such as selenium, triclosan, phthalates along with a set criteria in the application of human biomonitoring data in health risk assessment related to humans.…”

Section: Generalmentioning

confidence: 99%

Ecological and Human Health Risk Assessment

Charabi

Choudri

Ahmed

2018

Water Environment Research

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The review of literature in this paper includes the assessment of risk process and addresses issues of both human as well as ecological receptors. The main objective of this review is to highlight an overview of the scientific research literature published in year 2017. The review is focused on assessment of risk on human and ecology published in the literature such as analysis, methodology, interpretation, management, uncertainty, policy and regulatory guidance. The review on ecological and human health risk assessment is divided into two main sections namely ecological and human health. The focus of the review is on the risk assessment process as it is applied to human health, ecoological systems, site investigation, aspects of remediation as well as natural resources.

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“…26 Meanwhile, an increasing number of nations have implemented national human biomonitoring plans, which play a critical role in assessing environmental public health. 26,27 However, a national biomonitoring survey is typically supported by cohort research, which requires support from a great deal of resources. Thus, the development, improvement, and application of computational methods for assessing environmental exposure and predicting the distribution of toxic chemicals in the human body are urgently required.…”

Section: Introductionmentioning

confidence: 99%

Co-PBK: a computational biomonitoring tool for assessing chronic internal exposure to chemicals and metabolites

Zhang,

2023

Environ. Sci.: Processes Impacts

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A review of human biomonitoring data used in regulatory risk assessment under Canada's Chemicals Management Program

Cited by 34 publications

References 35 publications

Pharmaceutical market, environmental public policies and water quality: the case of the São Paulo Metropolitan Region, Brazil

Pharmaceutical market, environmental public policies and water quality: the case of the São Paulo Metropolitan Region, Brazil

Ecological and Human Health Risk Assessment

Co-PBK: a computational biomonitoring tool for assessing chronic internal exposure to chemicals and metabolites

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