Emergence and Spreading Potential of Zika Virus

Fajardo, Álvaro; Cristina, Juan; Moreno, Pilar

doi:10.3389/fmicb.2016.01667

Cited by 35 publications

(33 citation statements)

References 105 publications

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“…It can be spread by bites from virusinfected mosquitoes, similar to dengue virus and Japanese encephalitis virus in the same family. In recent years, the outbreak of ZV in tropical and subtropical regions has become a major public health issue [1,2]. Infection of ZV results in a self-limiting mild illness characterized by rash, fever, conjunctivitis, arthralgia, and arthritis [3].…”

Section: Introductionmentioning

confidence: 99%

Recombinant lipidated Zika virus envelope protein domain III elicits durable neutralizing antibody responses against Zika virus in mice

et al. 2020

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Background: The emergence of Zika virus (ZV) in tropical and subtropical areas of the world has created an urgent need for vaccines against ZV. However, approved vaccines that prevent ZV infection are not available. To develop an effective vaccine against ZV infection, a lipidated form of ZV envelope protein domain III that possesses an intrinsic adjuvant property was rationally designed. Our goal was to examine the immunogenicity of recombinant lipidated ZV envelope protein domain III (rLZE3) and evaluate its potential as a vaccine candidate against ZV.Methods: Recombinant ZV envelope protein domain III (rZE3) and rLZE3 were prepared with an Escherichia colibased system. Dendritic cell surface marker expression and cytokine production upon stimulation were analyzed to evaluate the function of rLZE3. Neutralizing antibody capacities were evaluated using focus reduction neutralization tests after immunization. To investigate the protective immunity in immunized mice, serum samples collected from immunized mice were adoptively transferred into AG129 mice, and then viremia levels and survival times were examined after ZV challenge.Results: rLZE3 alone but not rZE3 alone efficiently activated dendritic cells in vitro and was taken up by dendritic cells in vivo. Immunization of C57BL/6 mice with rLZE3 alone (without exogenous adjuvant) could induce ZVspecific neutralizing antibody responses. Furthermore, serum samples obtained from rLZE3-immunized mice provided protection as indicated by a reduction in viremia levels and prolongation of survival times after ZV challenge. Conclusion: These results indicate that rLZE3 is an excellent vaccine candidate and has great potential that should be evaluated in further preclinical studies.

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Section: Introductionmentioning

confidence: 99%

Recombinant lipidated Zika virus envelope protein domain III elicits durable neutralizing antibody responses against Zika virus in mice

et al. 2020

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“…[12, 13] . Generally, mosquito-borne flaviviruses are initially detected in blood and lymphoid tissue of infected animals and subsequently appear in peripheral organs and invade central nervous system via the hematogenous route [1, 2, 8] . In chronically infected SIV/SHIV RMs, ZIKV (PRVABC59) exhibited a similar pattern of viral kinetics as previously described in the ZIKV infected animals [8, 11] .…”

Section: Discussionmentioning

confidence: 99%

“…Such interactions are marked by the potential that a pathogen has for changing the epidemiology, pathogenesis, immunology, and response to therapy of the other [1] . In the last six decades since its discovery, Zika virus (ZIKV) has been considered a mild human pathogen; but recently, it has emerged as a threat to global health, showing increased virulence, rapid spread and an association with grave neurological complications [2, 3] . The two major clinical complications for ZIKV infection are microcephaly of newborns from women infected during early pregnancy [4] , and neurological conditions in adults, including Guillain-Barré syndrome [1] .…”

Section: Introductionmentioning

confidence: 99%

SIV/SHIV-Zika coinfection does not alter disease pathogenesis in adult non-pregnant Rhesus Macaques

Bidokhti

Dutta

Madduri

et al. 2018

Preprint

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Due to the large geographical overlap of populations exposed to Zika virus (ZIKV) and human immunodeficiency virus (HIV), understanding disease pathogenesis in such coinfections is urgently needed. We used chronically infected simian immunodeficiency virus and chimeric simian human immunodeficiency virus (SIV/SHIV) macaques and inoculated with ZIKV. Plasma viral loads of both SIV/SHIV and ZIKV showed no significant changes as compared to ZIKV alone-infected animals. Tissue clearance of ZIKV was observed similarly. Furthermore, minimal changes in cytokines/chemokines were observed. Collectively, these data suggest that coinfection may not alter disease pathogenesis and warrants large HIV-ZIKV epidemiological studies to validate these findings.Author SummaryThe co-infection incidence of human immunodeficiency virus (HIV) infection and neglected tropical infectious diseases is increasing due to the large geographical overlap of populations exposed to both of these viruses. Thus, researching on such coinfection is of particular importance. In this study, we investigated HIV-ZIKV coinfection dynamics in adult non-pregnant Rhesus Macaques model chronically infected with simian immunodeficiency virus (SIV) - or chimeric simian human immunodeficiency virus (SHIV). We found that post ZIKV inoculation, plasma viral loads were similar to ZIKV alone infected animals in addition to minimal changes of cytokines. Dynamics of SIV and SHIV also did not change. Tissue clearance of ZIKV was found 67 months later. Our findings provide insights into HIV-ZKIV coinfection to determine the alteration of their pathogenesis.

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“…Zika virus (ZIKV) is a mosquito‐borne virus that caused epidemics of Zika disease in Brazil in 2015, then spread into other parts of South America, the Caribbean, and North America . Zika disease has been associated with severe neurological complications, including Guillain–Barré syndrome in adults and microcephaly in neonates .…”

Section: Figurementioning

confidence: 99%

Valve‐Enabled Sample Preparation and RNA Amplification in a Coffee Mug for Zika Virus Detection

et al. 2018

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The recent outbreaks of Zika virus (ZIKV) infection represent ap ublic health challenge.R apid, cost-effective,a nd reliable diagnostic tools for ZIKV detection at the point of care (POC) are highly desirable,e specially for resource-limited nations.T oaddress the need, we have developed an integrated device to achieve sample-to-answer ZIKV detection. The device features innovative ball-based valves enabling the storage and sequential delivery of reagents for virus lysis and apaper-based unit for RNAenrichmentand purification. The paper unit is placed in ac ommercially available coffee mug that provides ac onstant temperature for reverse transcription loop-mediated isothermal amplification (RT-LAMP), followed by colorimetric detection by naked eye or ac ellphone camera. Using the device,w ed emonstrated the reproducible detection of ZIKV in human urine and saliva samples.Supportinginformation and the ORCID identification number(s) for the author(s) of this article can be found under: https://doi.

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Emergence and Spreading Potential of Zika Virus

Cited by 35 publications

References 105 publications

Recombinant lipidated Zika virus envelope protein domain III elicits durable neutralizing antibody responses against Zika virus in mice

Recombinant lipidated Zika virus envelope protein domain III elicits durable neutralizing antibody responses against Zika virus in mice

SIV/SHIV-Zika coinfection does not alter disease pathogenesis in adult non-pregnant Rhesus Macaques

Valve‐Enabled Sample Preparation and RNA Amplification in a Coffee Mug for Zika Virus Detection

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