Correction: Corrigendum: A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect

Abstract

During the preparation of the PCR gel panels in Fig. 1b,c, duplicate or otherwise irrelevant lanes were excised; these excisions were not noted in the published figure as per the Nature journal policy. We are now correcting these figure panels as below. Figure 1b was assembled as a composite from multiple gels that were run in parallel using samples obtained from the same experiment. The corrected Fig. 1b below provides the demarcation as required by the Nature editorial policy. The original unprocessed gel images are provided in the Supplementary Information with the relevant corresponding bands denoted. Figure 1c was assembled from two gels run in parallel using samples obtained from the same experiment. We have not been able to provide all the original data used to assemble Fig. 1c. We have repeated the experiment and confirmed the original results; these new data are now reproduced below as the corrected Fig. 1c. The original unprocessed gel image is provided in the Supplementary Information. In addition, the original base pair markers in Fig. 1b were incorrect; the correct markers are shown below.These corrections do not alter the original meaning of the experiments, their results, their interpretation, or the conclusions of the paper. We apologize for any confusion this may have caused to the readers of Nature Communications.

Crosstalk between metabolic reprogramming and epigenetics in cancer: updates on mechanisms and therapeutic opportunities

“…Promoter hypermethylation causes the inactivation of DERL3, a crucial regulator of the endoplasmic reticulum-associated protein degradation pathway, which enhances the expression of GLUT1 and promotes aerobic glycolysis. This is mediated by DNMT1 and DNMT3B [210]. In addition, elevated CAV-1 expression by hypomethylation of the promoter CpG site upregulates GLUT3 transcription, stimulates glucose uptake, and increases aerobic glycolysis [211].…”

How DNA methylation affects the Warburg effect

“…Increases in the expression of GLUT significantly increase the uptake and transport of glucose and ultimately promote aerobic glycolysis. The final metabolites, lactate and pyruvate, acidify the tumor microenvironment and enhance tumor proliferation and invasion [26,27]. In addition to GLUT1, GLUT3 has also been reported to be related to DNA methylation.…”