True Vitamin D Deficiency with Secondary Hyperparathyroidism

Pharmacokinetics of dexmedetomidine administered to patients with end-stage renal failure and secondary hyperparathyroidism undergoing general anaesthesia

“…The number of patients suffering from renal failure and secondary hyperparathyroidism has been increasing in recent years . Secondary hyperparathyroidism, which causes long‐term hypocalcaemia, can result in hyperglycaemia, blood‐fat metabolic disturbances, blood pressure dysregulation and ectopic soft tissue calcification at the joints, muscles, brain and blood vessels.…”

Dr. Koeckhoven, et al reply

“…We highly appreciate the letter of Tufan, et al 1 In our study, we investigated the relationship between serum 25(OH)D level and upper leg muscle strength in a large cohort of patients with knee osteoarthritis (OA) in the Amsterdam Osteoarthritis cohort using the recommended definition of Vitamin D deficiency (< 50 nmol/l = 20 ng/ml) 3 . Previously, low 25(OH)D and elevated PTH levels were found to be independent determinants of muscle weakness 4 .…”