Clinical Significance of Tissue Factor Pathway Inhibitor 2, a Serum Biomarker Candidate for Ovarian Clear Cell Carcinoma

Arakawa, Noriaki; Kobayashi, Hiroshi; Yonemoto, Naohiro; Masuishi, Yusuke; Ino, Yoko; Shinmoto, Hiroshi; Furukawa, Naoto; Ohtake, Norihisa; Miyagi, Yohei; Hirahara, Fumiki; Hirano, Hisashi; Miyagi, Etsuko

doi:10.1371/journal.pone.0165609

Cited by 28 publications

(55 citation statements)

References 39 publications

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“…TFPI2 is an inhibitor of the tissue factor pathway involved in blood coagulation. Gene expression of TFPI2 was decreased in samples of bladder tumors (43) and cervical tumors (44), while TFPI2 protein concentrations in serum were higher in ovarian clear cell adenocarcinoma patients (45,46). Hypermethylation, generally associated with decreased gene expression (47), was detected for TFPI2 in multiple types of cancer compared to normal adjacent tissues (48)(49)(50)(51)(52).…”

Section: Discussionmentioning

confidence: 99%

“…The blood samples were prepared for inductively coupled plasma-mass spectrometry (ICP-MS; operating conditions in Supplementary Table 1) by a direct alkali dilution method (30). Briefly, blood samples were diluted 1:17-44 with an alkali solution consisting of 2% butanol (Honeywell Research Chemicals, Germany), 0.05% EDTA (Sigma-Aldrich, USA), 0.05% Triton X-100 (Sigma-Aldrich), 1% NH 4 OH (Romil, UK), and 20 µg/g internal standards 45 Sc, 72 Ge, 103 Rh, 175 Lu, and 193 Ir. Before analysis, the diluted samples were sonicated for 5 min, and centrifuged at 694 g for 5 min.…”

Section: Arsenic Exposure and Metabolism Efficiency Assessmentmentioning

confidence: 99%

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Arsenic Exposure and Cancer-Related Proteins in Urine of Indigenous Bolivian Women

Loma

Gliga

Levi

et al. 2020

Front. Public Health

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Indigenous people living in the Bolivian Andes are exposed through their drinking water to inorganic arsenic, a potent carcinogen. However, the health consequences of arsenic exposure in this region are unknown. The aim of this study was to evaluate associations between arsenic exposure and changes in cancer-related proteins in indigenous women (n = 176) from communities around the Andean Lake Poopó, Bolivia. Arsenic exposure was assessed in whole blood (B-As) and urine (as the sum of arsenic metabolites, U-As) by inductively coupled plasma-mass spectrometry (ICP-MS). Cancer-related proteins (N = 92) were measured in urine using the proximity extension assay. The median B-As concentration was 2.1 (range 0.60–9.1) ng/g, and U-As concentration was 67 (12–399) μg/L. Using linear regression models adjusted for age, urinary osmolality, and urinary leukocytes, we identified associations between B-As and four putative cancer-related proteins: FASLG, SEZ6L, LYPD3, and TFPI2. Increasing B-As concentrations were associated with lower protein expression of SEZ6L, LYPD3, and TFPI2, and with higher expression of FASLG in urine (no association was statistically significant after correcting for multiple comparisons). The associations were similar across groups with different arsenic metabolism efficiency, a susceptibility factor for arsenic toxicity. In conclusion, arsenic exposure in this region was associated with changes in the expression of some cancer-related proteins in urine. Future research is warranted to understand if these proteins could serve as valid biomarkers for arsenic-related toxicity.

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Section: Discussionmentioning

confidence: 99%

Section: Arsenic Exposure and Metabolism Efficiency Assessmentmentioning

confidence: 99%

Arsenic Exposure and Cancer-Related Proteins in Urine of Indigenous Bolivian Women

Loma

Gliga

Levi

et al. 2020

Front. Public Health

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“…Published in 2019, Kobayashi et al made a literature review about the advances in the imaging and the non-invasive tests and biomarkers of early detection of the malignant transformation of benign ovarian endometrioma to endometriosis-associated ovarian cancer (23). Several techniques are investigated such as electronic absorption spectroscopy of cyst fluid hemoglobin or dosage of serum Tissue Factor Pathway Inhibitor-2 (TFPI2) (elevated with malignant transformation) (24).…”

Section: Discussionmentioning

confidence: 99%

Endometriotic Mass After Hysterectomy in a 61 Year Old Post-menopausal Woman: A Case Report and Update

Mathey¹,

Joliniere²,

Major³

et al. 2019

Front. Surg.

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Endometriosis is a common, hormone-dependent gynecologic disease. Undiagnosed in large proportion of women, managing therapies depend on the impact of quality of life and includes hormonal treatment and pelvic surgery. Less likely endometriosis can occur in post-menopausal women. Malignant transformation of endometriosis is a rare but well-described process, most of time occurring in the ovary, and justifies the practitioner not to underestimate this pathology. We present a case of a 61 year old woman with a symptomatic endometriotic pelvic mass, status post hysterectomy, with no history of endometriosis diagnosed beforehand.

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“…Currently available serum-based tests, including CA125, have been disappointing (4). Arakawa et al (21), reported that serum Tissue Factor Pathway Inhibitor-2 (TFPI2) levels were elevated only in patients with CCC among epithelial ovarian cancer. The preliminary study demonstrated that patients with endometriosis presented mild-to-moderate elevation of serum CA125 levels, but may be characterized by normal serum levels of TFPI2 (21).…”

Section: Discussionmentioning

confidence: 99%

Modern approaches to noninvasive diagnosis of malignant transformation of endometriosis

et al. 2018

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Endometriosis-associated ovarian cancer (EAOC) is a rare entity and has highly variable morphological presentations. Mural nodules can be seen in EAOC and benign ovarian endometrioma (OE), which causes a diagnostic dilemma. The differential diagnosis between early-stage EAOC with predominantly cystic appearances and benign OE remains a challenge for physicians. This study will summarize recent knowledge of diagnosis of malignant transformation of endometriosis that have been studied through an innovative approach based on a wide array of novel technologies. Using PubMed database, we focused on the biochemical and technical advancement in the differential diagnosis of benign and malignant endometriosis. Compared with the subjects with benign OE, cyst fluid hemoglobin and iron-related compounds levels were significantly lower in patients with EAOC. This observation opens up the possibility of early diagnosis before morphological variations are captured through ultrasonographic and magnetic resonance (MR) imaging diagnosis. The metallobiology technology offers one solution to this challenge. We discuss the noninvasive diagnosis of EAOC via various imaging methods, including electronic absorption spectroscopy, near infrared approach and MR transverse relaxometry. Special emphasis is given to recent advances in the noninvasive imaging modalities.

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Clinical Significance of Tissue Factor Pathway Inhibitor 2, a Serum Biomarker Candidate for Ovarian Clear Cell Carcinoma

Cited by 28 publications

References 39 publications

Arsenic Exposure and Cancer-Related Proteins in Urine of Indigenous Bolivian Women

Arsenic Exposure and Cancer-Related Proteins in Urine of Indigenous Bolivian Women

Endometriotic Mass After Hysterectomy in a 61 Year Old Post-menopausal Woman: A Case Report and Update

Modern approaches to noninvasive diagnosis of malignant transformation of endometriosis

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