Cohort profile: the Baependi Heart Study—a family-based, highly admixed cohort study in a rural Brazilian town

Egan, Kieren; Schantz, Malcolm von; Negrão, André Brooking; Santos, Hadassa Campos; Horimoto, Andréa Roseli Vançan Russo; Duarte, Nubia Esteban; Gonçalves, Guilherme C; Soler, Júlia Maria Pavan; Andrade, Mariza de; Lorenzi-Filho, Geraldo; Vallada, Homero; Taporoski, Tâmara P.; Pedrazzoli, Mário; Azambujá, Ana Paula; Oliveira, Camila Maciel de; Alvim, Rafael de Oliveira; Krieger, José Eduardo; Pereira, Alexandre C.

doi:10.1136/bmjopen-2016-011598

Cited by 35 publications

(32 citation statements)

References 37 publications

(26 reference statements)

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“…All procedures were conducted with informed and written consent of the participants. The methodology for recruitment has been described previously 17,18 . Briefly, all extended family members aged above 18 years of probands who had initially been randomly selected from 11 out of 12 census districts in Baependi were initially invited to participate in the full study.…”

Section: Methodsmentioning

confidence: 99%

Early chronotype with advanced activity rhythms and dim light melatonin onset in a rural population

Ruiz

Beijamini

Beale

et al. 2020

Journal of Pineal Research

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Studying communities at different stages of urbanisation and industrialisation can teach us how timing and intensity of light affect the circadian clock under real‐life conditions. We have previously described a strong tendency towards morningness in the Baependi Heart Study, located in a small rural town in Brazil. Here, we tested the hypothesis that this morningness tendency is associated with early circadian phase based on objective measurements (as determined by dim light melatonin onset, DLMO, and activity) and light exposure. We also analysed how well the previously collected chronotype questionnaire data were able to predict these DLMO values. The average DLMO observed in 73 participants (40 female) was 20:03 ± 01:21, SD, with an earlier average onset in men (19:38 ± 01:16) than in women (20:24 ± 01:21; P ≤ .01). However, men presented larger phase angle between DLMO and sleep onset time as measured by actigraphy (4.11 hours vs 3.16 hours; P ≤ .01). Correlational analysis indicated associations between light exposure, activity rhythms and DLMO, such that early DLMO was observed in participants with higher exposure to light, higher activity and earlier light exposure. The strongest significant predictor of DLMO was morningness‐eveningness questionnaire (MEQ) (beta=−0.35, P ≤ .05), followed by age (beta = −0.47, P ≤ .01). Sex, light exposure and variables derived from the Munich chronotype questionnaire were not significant predictors. Our observations demonstrate that both early sleep patterns and earlier circadian phase have been retained in this small rural town in spite of availability of electrification, in contrast to metropolitan postindustrial areas.

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Section: Methodsmentioning

confidence: 99%

Early chronotype with advanced activity rhythms and dim light melatonin onset in a rural population

Ruiz

Beijamini

Beale

et al. 2020

Journal of Pineal Research

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“…(Egan, von Schantz et al, 2016) In this highly admixed population, a mixture of European, African, and Amerindian ancestries is found within virtually all individuals. Here, we aimed to determine whether the degree of each of these ancestries was associated with diurnal preference, based on the morningnesseveningness questionnaire (MEQ) (Horne & Östberg, 1976).…”

Section: Introductionmentioning

confidence: 99%

Amerindian (but not African or European) ancestry is significantly associated with diurnal preference within an admixed Brazilian population

Egan

Santos

Beijamini

et al. 2017

Chronobiology International

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Significant questions remain unanswered regarding the genetic versus environmental contributions to racial/ethnic differences in sleep and circadian rhythms. We addressed this question by investigating the association between diurnal preference, using the Morningness-Eveningness questionnaire (MEQ), and genetic ancestry within the Baependi Heart Study cohort, a highly admixed Brazilian population based in a rural town. Analysis was performed using measures of ancestry, using the Admixture program, and MEQ from 1,453 individuals. We found an association between the degree of Amerindian (but not European of African) ancestry and morningness, equating to 0.16 units for each additional percent of Amerindian ancestry, after adjustment for age, sex, education, and residential zone. To our knowledge, this is the first published report identifying an association between genetic ancestry and MEQ, and above all, the first one based on ancestral contributions within individuals living in the same community. This previously unknown ancestral dimension of diurnal preference suggests a stratification between racial/ethnic groups in an as yet unknown number of genetic polymorphisms.

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“…The Baependi Heart Study is the first studies in Brazil clustering families for analyze the relationship between genetic and cardiovascular risk factors [1][2][3][4][5][6]. It had started in 2005 with partnerships among some Brazilian Universities for research and outreach projects.…”

Section: Introductionmentioning

confidence: 99%

THE BAEPENDI “LITTLE HEART” STUDY: Strategies in Child Education Related to Cardiometabolic Risk Factors for Reducing Morbidity and Mortality in a Developing Country

Oliveira¹

2017

EMIJ

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Submit Manuscript | http://medcraveonline.com IntroductionThe Baependi Heart Study is the first studies in Brazil clustering families for analyze the relationship between genetic and cardiovascular risk factors [1][2][3][4][5][6]. It had started in 2005 with partnerships among some Brazilian Universities for research and outreach projects.Then, ten years later, in March, 2015 a new project was developed and it couldn't be more promising. It was called The Baependi "Little Heart" Study. It was related to child and adolescent education for prevention of cardiovascular risk factors in schools of three different cities. Local teachers keep disseminating concepts related to health promotion after learning this method, since the goal is to reduce non-communicable chronic diseases, a major cause of global morbidity and mortality have followed it.The aim of this project was introduce concepts about prevention of some prevalent diseases in this country, improving physical activity and food inhabits, in a simple and cheap method to teach children about serious matter in a playful way. MethodsWe worked using puppets (named Insulin, Pancreas, Heart, Carrot and so on) to teach about prevention of cardiovascular diseases, healthy lifestyle, hygiene habits and prevention of epidemic diseases (Figure 1). It was mean to be fun for the kids. We needed only the play designed for this purpose, puppets and a frame with a curtain. And sometimes a microphone and an amplifier, for a large audience. The method is flexible in a matter of how to work on it. Students of medical, nutrition, and nursey schools were responsible for developing of activities at school, and sometimes the actors holding the puppets behind scenario could be the children (Figure 2). Universities for research and outreach projects. Ten years later, a new project was developed. It was related to child and adolescent education for prevention of cardiovascular risk factors in school, followed by local teachers who continued to disseminate health promotion, since the goal is to reduce non-communicable chronic diseases, a major cause of global morbidity and mortality.

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Cohort profile: the Baependi Heart Study—a family-based, highly admixed cohort study in a rural Brazilian town

Cited by 35 publications

References 37 publications

Early chronotype with advanced activity rhythms and dim light melatonin onset in a rural population

Early chronotype with advanced activity rhythms and dim light melatonin onset in a rural population

Amerindian (but not African or European) ancestry is significantly associated with diurnal preference within an admixed Brazilian population

THE BAEPENDI “LITTLE HEART” STUDY: Strategies in Child Education Related to Cardiometabolic Risk Factors for Reducing Morbidity and Mortality in a Developing Country

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