Comprehensive treatment with Chinese medicine in patients with advanced non-small cell lung cancer: A multicenter, prospective, cohort study

Liu, Jie; Lin, Hong; Hou, Wei; Bao, Hua; Zhang, Pei tong; Li, Jie; Wang, Shen yu; Xie, Ying; Zhang, Yue; Xie, Guang Ru; Zhang, Mei ying; Shi, Wen; Guan, Nian bo; Guan, Tianwang; Li, Cong huang; Lu, Li yuan; Zhang, Ying; Li, Dao rui; Líu, Hao

doi:10.1007/s11655-016-2737-1

Cited by 18 publications

(11 citation statements)

References 27 publications

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“…You et al have uncovered that a Chinese Herbal Medicine Baicalin represses cell proliferation, migration, invasion, and induces cell apoptosis in NSCLC cells 22. Liu et al have found that treatment with Chinese Medicine may prolong the survival rate of NSCLC patients 23. The anti-tumor effect of Cordyceps militaris was associated with an induction of cell cycle arrest and mitochondrial-mediated apoptosis 24.…”

Section: Discussionmentioning

confidence: 99%

Se-Enriched Cordyceps militaris Inhibits Cell Proliferation, Induces Cell Apoptosis, And Causes G2/M Phase Arrest In Human Non-Small Cell Lung Cancer Cells

Luo¹,

Ran²,

Yao³

et al. 2019

OTT

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BackgroundThe anticancer effects of cordyceps on various tumors have been reported. However, little is known about the role of selenium (Se)-enriched Cordyceps militaris in non-small cell lung cancer (NSCLC). In this study, the effects of Se-enriched Cordyceps militaris on cell proliferation, cell apoptosis and cell cycle in NSCLC cell line NCI-H292 and A549 were investigated.MethodsCCK-8 assay was used to determine the appropriate concentrations of Se-enriched Cordyceps militaris in NSCLC (namely NCI-H292 and A549) cells. Colony formation assay, flow cytometric and Hoechst 33342 staining assays, and flow cytometric analysis were separately employed to assess the effect of increased Se-enriched Cordyceps militaris on NSCLC cell viability, cell apoptosis and cell-cycle distribution. Finally, the qPCR and Western blot assays were, respectively, applied to evaluate the effects of Se-enriched Cordyceps militaris on the expression of pro-apoptotic member BAX and the anti-apoptotic member BCL-2, as well as of G2/M cell cycle regulatory proteins CDK1 and cyclin B1.ResultsThe concentration of Se-enriched Cordyceps militaris was 0, 4, 8, 12 mg/mL for NCI-H292 cells, and 0, 12.5, 25, 50 mg/mL for A549 cells. NSCLC cells treated with increased Se-enriched Cordyceps militaris showed the inhibited cell viability. Se-enriched Cordyceps militaris induced NSCLC cell apoptosis in concentration-dependent manner. Consistently, Se-enriched Cordyceps militaris diminished the ratio of anti-apoptotic member BCL-2 and pro-apoptotic member BAX at mRNA and protein levels in NSCLC cells. The percentage in G2/M phase was increased in NSCLC cells treated with increased Se-enriched Cordyceps militaris. Downregulation of G2/M cell cycle regulatory proteins CDK1 and cyclin B1 at mRNA and protein levels in NSCLC cells further confirmed the effects of Se-enriched Cordyceps militaris on cell cycle.ConclusionThis study demonstrated the inhibitory role of Se-enriched Cordyceps militaris in cell proliferation and its facilitating role in cell apoptosis and cell cycle in NSCLC cells, suggesting an alternative therapeutic strategy for NSCLC treatment.

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Section: Discussionmentioning

confidence: 99%

Se-Enriched Cordyceps militaris Inhibits Cell Proliferation, Induces Cell Apoptosis, And Causes G2/M Phase Arrest In Human Non-Small Cell Lung Cancer Cells

Luo¹,

Ran²,

Yao³

et al. 2019

OTT

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“…[20–22] A prospective cohort study involving patients with advanced NSCLC revealed that the median survival was prolonged in the group treated with integrated traditional Chinese medicine (TCM) and CCT compared to the CCT-alone group (16.60 vs 13.13 months, P < .01). [23] A meta-analysis demonstrated that concurrent administration of TCM herbs plus EGFR tyrosine kinase inhibitor (EGFR-TKI) resulted in a significantly better response rate, as well as 1- and 2-year survival rates, compared to EGFR-TKI alone in patients with advanced NSCLC. [24] In a randomized controlled trial involving patients with stage IIIB and IV NSCLC, intravenous pharmacopuncture (Cinobufacini injection), oral herbal decoction, and acupoint application (mono-TCM treatments) for 21 days were shown to have times to progression and OSs similar to those of patients treated with chemotherapy alone and higher 1-year survival rate (78.1% vs 53.1%, P = .035).…”

Section: Discussionmentioning

confidence: 99%

Integrative cancer treatment may have a survival benefit in patients with lung cancer

et al. 2019

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Integrative oncology is being increasingly adopted in mainstream cancer care to strengthen anticancer effects and to control cancer-related symptoms. The objective of this study is to identify the characteristics of patients with lung cancer treated at an integrative cancer center in Korea and to determine the effects of integrative cancer treatment (ICT) on survival outcome in traditional Korean medicine (TKM). We reviewed medical records for lung cancer patients who visited a single integrative clinical setting, East-West Cancer Center, between January 2014 and December 2015. We classified the patients into groups according to their ICT and whether or not they underwent anticancer traditional Korean Medicine treatment with a multiherbal formula containing Panax notoginseng Radix , Cordyceps militaris , P ginseng C.A.Mey., and Boswellia carterii BIRDWOOD (HangAmDan-B), with a herbal formula containing Rhus verniciflua Stoke , or with cultivated wild ginseng pharmacopuncture. A descriptive analysis of the characteristics and a survival analysis using the Kaplan-Meier curves with log rank test and a Cox proportional hazard model were performed. A total of 91 patients were included, and the majority had advanced-stage cancer. Of those patients, 45.1% were in the mono-TKM group and 39.6% were integrative group. Patients with advanced stage had significantly higher mortality than patients with early stage (crude hazard ratio [HR]: 4.41, 95% confidence interval [CI]: 1.56–12.5; adjusted HR: 6.31, 95% CI: 1.24–32.1). In the unadjusted model, for patients in the integrative group, the mortality rate was reduced by 50% compared to mono-TKM group with statistical significance. After adjusting confounders, the mortality rate of integrative group was reduced by 6% compared to mono-TKM group, suggesting positive effect on survival probability of integrative group. The results suggest that integration of TKM and conventional cancer treatment may have survival benefits in patients with lung cancer. Even though this study has limitations including heterogeneity between treatment groups, the study results suggest that ICT has positive effect on survival probability. To clarify the impacts of ICT for lung cancer and other cancers on survival outcome, further prospective study with a rigorous study design is required in multiclinical setting.

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“…Good-quality English-language published trials in this area are rare. Liu et al [44] reported a RCT of 474 stage IIIeIV non-small cell lung cancer (NSCLC) patients and compared the outcome of additional Chinese herbal medicine (IM group) with the standard therapy (radiotherapy, chemotherapy and optimal supportive therapy according to NCCN guidelines) to standard therapy alone (WM group). The median overall survival was 16.60 and 13.13 months in the IM and WM groups, respectively (P < 0.01).…”

Section: Herbal Medicine Decoctionmentioning

confidence: 99%

Chinese Medicine in Cancer Treatment – How is it Practised in the East and the West?

Chan

Lee

et al. 2019

Clinical Oncology

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Chinese medicine therapies in cancer treatment are very common in the East. Although it is usually classified as a form of complementary and alternative therapy in the West, Chinese medicine is an independent medical profession in Hong Kong and mainland China. It has a different perspective in understanding health and diseases compared with Western medicine. In oncology practice, whereas Western medicine focuses on direct tumour eradication by surgery, radiation therapy and systemic therapies, Chinese medicine focuses on restoring body balance and enhancing the body's defences (immunity), in addition to some cytotoxic herbal therapies. Most often patients, especially those in the East, receive both treatments. Chinese medicine is also commonly used to reduce side-effects from chemotherapy or radiation therapy, to aid recovery after an operation, to palliate symptoms and to address survivorship issues. However, this raises concerns of drugeherb interactions and toxicity in combination therapies. Commonly used Chinese medicine treatment modalities include acupuncture, moxibustion, diet therapy, prescribed Chinese medicine herbal decoction, single Chinese medicine herbs or supplements and tai chi. Although there is an increasing trend of Chinese medicine use in cancer patients in both the East and the West, the scientific evidence of safety and efficacy is often questioned by oncologists. This article reviews the current evidence in different Chinese medicine therapies in cancer management in both the East and the West.

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Comprehensive treatment with Chinese medicine in patients with advanced non-small cell lung cancer: A multicenter, prospective, cohort study

Abstract: Additional CM may prolong survival and improve the QOL patients with NSCLC. The adverse effects of radio- and chemotherapy may be attenuated as CM is used in combination with conventional treatments.

Cited by 18 publications

References 27 publications

<p>Se-Enriched <em>Cordyceps militaris</em> Inhibits Cell Proliferation, Induces Cell Apoptosis, And Causes G2/M Phase Arrest In Human Non-Small Cell Lung Cancer Cells</p>

<p>Se-Enriched <em>Cordyceps militaris</em> Inhibits Cell Proliferation, Induces Cell Apoptosis, And Causes G2/M Phase Arrest In Human Non-Small Cell Lung Cancer Cells</p>

Integrative cancer treatment may have a survival benefit in patients with lung cancer

Chinese Medicine in Cancer Treatment – How is it Practised in the East and the West?

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