2016
DOI: 10.1073/pnas.1607003113
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Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages

Abstract: Macrophages are central in coordinating immune responses, tissue repair, and regeneration, with different subtypes being associated with inflammation-initiating and proresolving actions. We recently identified a family of macrophage-derived proresolving and tissue regenerative molecules coined maresin conjugates in tissue regeneration (MCTR). Herein, using lipid mediator profiling we identified MCTR in human serum, lymph nodes, and plasma and investigated MCTR biosynthetic pathways in human macrophages. With h… Show more

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Cited by 81 publications
(101 citation statements)
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“…For complete stereochemistry of individual SPMs, see refs. 72, 104, 107.) Low‐dose aspirin triggers the 17 R and 18 R/S epimers of the Rvs (9, 53) and 17 R ‐epimer PDs (165, 166).…”
Section: Alpha Signals Omega In the Cascadementioning
confidence: 99%
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“…For complete stereochemistry of individual SPMs, see refs. 72, 104, 107.) Low‐dose aspirin triggers the 17 R and 18 R/S epimers of the Rvs (9, 53) and 17 R ‐epimer PDs (165, 166).…”
Section: Alpha Signals Omega In the Cascadementioning
confidence: 99%
“…The resulting reflow injury is an example of acute leukocyte‐mediated tissue damage of the delicate lung tissues. When treated with just 50 ng per mouse, which is a low dose compared with current anti‐inflammatories (3, 5), each MCTR protects the organ from secondary injury (104).…”
Section: Tissue Regeneration From Signaling Resolution In Response Tomentioning
confidence: 99%
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“…See refs. (Serhan and Petasis, 2011; Winkler et al, 2016; Aursnes et al, 2015; Tungen et al, 2014; Dalli et al, 2016b) for original reports, total organic synthesis and stereochemical assignments and the text for further details.…”
Section: Figurementioning
confidence: 99%
“…Upon direct conjugation of GSH to 13,14‐epoxy‐maresin (an intermediate of MaR‐1 and MaR‐2 biosynthesis) by GSH transferase, also known as LTC 4 synthase, and sequential cleavage of peptide bonds by peptidases, the following maresin conjugated in tissue regeneration (MCTR) are formed: MCTR1 (13‐glutathionyl‐14‐hydroxy DHA), MCTR2 (13‐cysteinylglycinyl‐14‐hydroxy DHA), and MCTR3 (13‐cysteinyl‐14‐hydroxy DHA) . In addition, attack of GSH at the 7,8‐epoxide intermediate of RvD yields resolvin conjugate in tissue regeneration 1 (RCTR1) that is in turn cleaved into RCTR2 by γ‐glutamyltranspeptidase and into RCTR3 via peptidases .…”
Section: Spm Biosynthesis and Bioactionsmentioning
confidence: 99%