Efficiency and safety of a <i>Curcuma</i> extract combined with visible blue light phototherapy on adults with plaque psoriasis: A phase <scp>IV</scp>, randomized, open pilot clinical trial

Ramírez-Boscá, A.; Navarro-López, Vicente; Carrión-Gutiérrez, Miguel A; Martínez‐Andrés, Asunción; Vilata-Corell, J.J.; Asín-Llorca, Manuel; Calle, José Francisco Horga de la; Bernd, August

doi:10.1111/1346-8138.13668

Cited by 6 publications

(5 citation statements)

References 3 publications

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“…They observed a slower response in the first arm. The data also suggested that oral curcumin plus visible light had the same efficacy as PUVA, but a safer profile [41]. On the other hand, Kurd et al showed that oral curcumin (4.5 g/day) yielded a low response rate in 12 patients with moderate to severe psoriasis [42].…”

Section: Oral Antioxidant Supplementationmentioning

confidence: 99%

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Therapies with Antioxidant Potential in Psoriasis, Vitiligo, and Lichen Planus

et al. 2021

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Oxidative stress plays an important pathogenetic role in many chronic inflammatory diseases, including those of dermatological interest. In particular, regarding psoriasis, vitiligo, and lichen planus, excess reactive oxygen species and a decline in endogenous antioxidant systems are observed. In this regard, treatments with antioxidant properties could be appropriate therapeutic options. To date, clinical trials in dermatology on these treatments are limited. We reviewed the available studies on the efficacy of antioxidant therapies in psoriasis, vitiligo, and lichen planus. The role of herbal derivatives, vitamins, and trace elements was analyzed. The antioxidant properties of conventional therapies were also evaluated. Data from the literature suggest that antioxidants might be useful, but available studies on this topic are limited, heterogeneous, not completely standardized, and on small populations. Furthermore, in most cases, antioxidants alone are unable to induce significant clinical changes, except perhaps in mild forms, and must be used in conjunction with standard drug treatments to achieve measurable results. Further studies need to be conducted, considering larger populations and using internationally validated scales, in order to compare the results and clinical efficacy.

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Section: Oral Antioxidant Supplementationmentioning

confidence: 99%

“…Curcumin was one of the main antioxidant drugs used. Six articles pointed out the high efficacy in moderate to severe PSO with both topical and oral supplementation [36][37][38][39][40][41]. Only one group of authors did not demonstrate a significant improvement in PSO patients with the use of oral Curcuma [42].…”

Section: Nutraceuticals As Antioxidantsmentioning

confidence: 99%

Therapies with Antioxidant Potential in Psoriasis, Vitiligo, and Lichen Planus

et al. 2021

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“…Herbal products were also used in combination with other therapies in the treatment of psoriasis. Oral administration of Curcuma longa extract combined with ultraviolet A (UVA) therapy showed higher effects on skin severity compared with psoralen plus UVA [128]. Treatment with total glucosides of paeony, a bioactive component derived from dry paeony root in combination with acitretin significantly improved PASI50 (50% reduction of PASI scores) in patients with moderate-to-severe plaque psoriasis, in comparison with placebo plus acitretin [129].…”

Section: Clinical Efficacy Of Natural Products In Psoriasis Treatmentmentioning

confidence: 99%

Signaling pathways and targets of natural products in psoriasis treatment

Nguyen

2022

Exploration of Medicine

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Aim: Psoriasis is a common chronic inflammatory skin disorder, which has adverse effects on patients’ quality of life. Natural products exhibit significant therapeutic capacities with small side effects and might be preferable alternative treatments for patients with psoriasis. This study summarizes the signaling pathways with the potential targets of natural products and their efficacy for psoriasis treatment. Methods: The literature for this article was acquired from PubMed and Web of Science, from January 2010 to December 2020. The keywords for searching included “psoriasis” and “natural product”, “herbal medicine”, “herbal therapy”, “medicinal plant”, “medicinal herb” or “pharmaceutical plant”. Results: Herbal extracts, natural compounds, and herbal prescriptions could regulate the signaling pathways to alleviate psoriasis symptoms, such as T helper 17 (Th17) differentiation, Janus kinase (JAK)/signal transducer and activator of transcription (STAT), nuclear factor-kappa B (NF-κB), mitogen‑activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR), and other signaling pathways, which are involved in the inflammatory response and keratinocyte hyperproliferation. The anti-psoriatic effect of natural products in clinical trials was summarized. Conclusions: Natural products exerted the anti-psoriatic effect by targeting multiple signaling pathways, providing evidence for the investigation of novel drugs. Further experimental research should be performed to screen and characterize the therapeutic targets of natural products for application in psoriasis treatment.

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“…Herbal products were also used in combination with other therapies in the treatment of psoriasis. Oral administration of Curcuma longa extract combined with ultraviolet A (UVA) therapy showed higher effects on skin severity compared with psoralen plus UVA [30]. Treatment with total glucosides of paeony, a bioactive component derived from dry paeony root in combination with acitretin signi cantly improved PASI50 (50% reduction of PASI scores) in patients with moderate-to-severe plaque psoriasis, in comparison with placebo plus acitretin [31].…”

Section: Clinical E Cacy Of Natural Products In Psoriasis Treatmentmentioning

confidence: 99%

Clinical efficacy and target signaling pathways of natural products in psoriasis treatment: a systematic review

Nguyen¹

2021

Preprint

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Background: Psoriasis is a common chronic inflammatory skin disorder, which has adverse effects on patients’ quality of life. Natural products exhibit significant therapeutic capacities with small side effects and might be preferable alternative treatments for patients with psoriasis. Aim of the review: This study summarizes the clinical efficacy of natural products and signaling pathways with the potential targets for psoriasis treatment. Methods: The literature for this article was acquired from PubMed and Web of Science, from Jan 2010 to Dec 2020. The keywords for searching included “psoriasis” and “natural product”, “herbal medicine”, “herbal therapy”, “medicinal plant”, “medicinal herb”, or “pharmaceutical plant”. Results: The anti-psoriatic effect of natural products in clinical studies was summarized. Herbal extracts, natural compounds, and herbal prescriptions could regulate the signaling pathways to alleviate psoriasis symptoms, such as Th17 differentiation, JAK/STAT, NF-κB, MAPK, PI3K/Akt/mTOR, and other signaling pathways, which are involved in the inflammatory response and keratinocyte hyperproliferation. Conclusion: Natural products exerted the anti-psoriatic effect by targeting multiple signaling pathways, providing evidence for the investigation of novel drugs. Further experimental research should be performed to screen and characterize the therapeutic targets of natural products for application in psoriasis treatment.

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Efficiency and safety of a Curcuma extract combined with visible blue light phototherapy on adults with plaque psoriasis: A phase IV, randomized, open pilot clinical trial

Cited by 6 publications

References 3 publications

Therapies with Antioxidant Potential in Psoriasis, Vitiligo, and Lichen Planus

Therapies with Antioxidant Potential in Psoriasis, Vitiligo, and Lichen Planus

Signaling pathways and targets of natural products in psoriasis treatment

Clinical efficacy and target signaling pathways of natural products in psoriasis treatment: a systematic review

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