Imaging for Oncologic Response Assessment in Lymphoma

Kulkarni, Naveen M.; Pinho, Daniella F.; Narayanan, Srikala; Kambadakone, Avinash; Abramson, Jeremy S.; Sahani, Dushyant V.

doi:10.2214/ajr.16.16180

Cited by 25 publications

(18 citation statements)

References 71 publications

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“…The value of imaging techniques relies on the capacity to differentiate reactive from malignant lymph node, but also to evaluate tumor extension, treatment response, and relapse. Additionally, the ability to discriminate lymphoma subtypes allows treatment assessment, outcome, and differentiation between indolent and aggressive NHL[41].…”

Section: Assessment Of Mediastinal Massesmentioning

confidence: 99%

Role of advanced magnetic resonance imaging in the assessment of malignancies of the mediastinum

Broncano¹,

Alvarado-Benavides

Bhalla

et al. 2019

WJR

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In the new era of functional magnetic resonance imaging (MRI), the utility of chest MRI is increasing exponentially due to several advances, including absence of ionizing radiation, excellent tissue contrast and high capability for lesion characterization and treatment monitoring. The application of several of these diagnostic weapons in a multiparametric fashion enables to better characterize thymic epithelial tumors and other mediastinal tumoral lesions, accurate assessment of the invasion of adjacent structures and detection of pathologic lymph nodes and metastasis. Also, “do not touch lesions” could be identified with the associated impact in the management of those patients. One of the hot-spots of the multiparametric chest MR is its ability to detect with acuity early response to treatment in patients with mediastinal malignant neoplasms. This has been related with higher rates of overall survival and progression free survival. Therefore, in this review we will analyze the current functional imaging techniques available ( 18 F-Fluorodeoxiglucose positron emission tomography/computed tomography, diffusion-weighted imaging, dynamic contrast-enhanced MRI, diffusion tensor imaging and MR spectroscopy) for the evaluation of mediastinal lesions, with a focus in their correct acquisition and post-processing. Also, to review the clinical applications of these techniques in the diagnostic approach of benign and malignant conditions of the mediastinum.

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Section: Assessment Of Mediastinal Massesmentioning

confidence: 99%

Role of advanced magnetic resonance imaging in the assessment of malignancies of the mediastinum

Broncano¹,

Alvarado-Benavides

Bhalla

et al. 2019

WJR

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“…2,33,34 Due to the overlap of the SUV of neoplasm with non-neoplasm, SUV value cannot reliably distinguish between these lesions. 35 In this setting, chemical shift MRI could be helpful to distinguish neoplasm from non-neoplasm based on threshold value of CSR.…”

Section: Discussionmentioning

confidence: 99%

The Value of CT and MRI for Determining Thymoma in Patients With Myasthenia Gravis

Tuấn¹,

Viện²,

Dong

et al. 2019

Cancer Control

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The aim of the study was to evaluate the usefulness of computed tomography (CT) and magnetic resonance imaging (MRI) for differentiating thymoma from nonthymoma abnormalities in patients with myasthenia gravis (MG). A cross-sectional study of 53 patients with MG, who had undergone surgical thymectomy, was conducted at 103 Hospital (Hanoi, Vietnam) and Cho Ray Hospital (Ho Chi Minh City, Vietnam) during August 2014 and January 2017. The CT and MRI images of patients with MG were qualitatively and quantitatively (radiodensity and chemical shift ratio [CSR]) analyzed to determine and compare their ability to distinguish thymoma from nonthymoma abnormalities. Logistic regression was used to identify the association between imaging parameters (eg, CSR) and the thymoma status. The receiver operating curve (ROC) analysis was used to determine the differentiating ability of CSR and radiodensity. As results, of the 53 patients with MG, 33 were with thymoma and 20 were with nonthymoma abnormalities. At qualitative assessment, MRI had significantly higher accuracy than did CT in differentiating thymoma from nonthymoma abnormalities (94.3% vs 83%). At quantitative assessment, both the radiodensity and CSR were significantly higher for thymoma compared with nonthymoma groups ( P < .001). The ROC analysis showed that CSR had significantly higher sensitivity (Se) and specificity (Sp) than radiodensity in discriminating between the 2 groups (CSR: Se 100%, Sp 95% vs radiodensity: Se 90.9%, Sp 70%). When combining both qualitative and quantitative parameters, MRI had even higher accuracy than did CT in thymoma diagnosis ( P = .031). In conclusion, chemical shift MRI was more accurate than CT for differentiating thymoma from nonthymoma in patients with MG.

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“…AIDS-related lymphoma also presents with multi-organ involvement and bulky disease [10]. 18 FDG PET/CT is a useful tool in initial staging and response assessment of lymphoma in both HIV-positive and HIV-negative patients [11,12]. The high-grade HIV-associated DLBCLs are more likely to show avid uptake of 18 F-FDG.…”

Section: Imaging In Hiv and Lymphomamentioning

confidence: 99%

Spectrum of imaging findings in AIDS-related diffuse large B cell lymphoma

Nganga

Gitau

2020

Insights Imaging

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Lymphoma in HIV-infected patients is AIDS defining. This is the second most common AIDS defining malignancy after Kaposi's sarcoma. Development of lymphoma in HIV patients is related to immunosuppression and high viral load. Co-infection with other lymphotrophic viruses especially EBV is also strongly associated with development of lymphoma in HIV patients. Despite advances in HAART therapy, incidence of diffuse large B cell lymphoma in HIVinfected patients remains significantly higher than in the general population. Early diagnosis is challenging due to presence of opportunistic infections and atypical presentation of the lymphoma in this subset of patients. Atypical imaging findings are not unusual, and the diagnosis of lymphoma on imaging is on many occasions unexpected as the patient would ideally be initially investigated for presumed opportunistic infection. Lymphoma treatment approaches in HIV patients are complicated by comorbidity with opportunistic infections and performance status of the patients. Treatment failure and early relapse are also common in AIDS-related lymphoma. This review article highlights the common and unusual multimodality imaging findings in HIV-associated lymphoma.

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Imaging for Oncologic Response Assessment in Lymphoma

Cited by 25 publications

References 71 publications

Role of advanced magnetic resonance imaging in the assessment of malignancies of the mediastinum

Role of advanced magnetic resonance imaging in the assessment of malignancies of the mediastinum

The Value of CT and MRI for Determining Thymoma in Patients With Myasthenia Gravis

Spectrum of imaging findings in AIDS-related diffuse large B cell lymphoma

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